Assessment of Structural Intolerance and Durability
General Structure Information 3vi8 PPARA human pprr alpha ligand binding domain in complex with a synthetic agonist aphm13 1.75Å AUTH N.KUWABARA,T.OYAMA,D.TOMIOKA,M.OHASHI,J.YANAGISAWA,AUTH 2 T.SHIMIZU,H.MIYACHITITL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS) HAVETITL 2 MULTIPLE BINDING POINTS THAT ACCOMMODATE LIGANDS IN VARIOUSTITL 3 CONFORMATIONS: PHENYLPROPANOIC ACID-TYPE PPAR LIGANDS BINDTITL 4 TO PPAR IN DIFFERENT CONFORMATIONS, DEPENDING ON THE SUBTYPEREF J.MED.CHEM. […]
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]
General Structure Information 4ic7 MAP2K5 crystal structure of the erk5 kinase domain in complex with an mkk5 binding fragment 2.6Å AUTH G.GLATZ,G.GOGL,A.ALEXA,A.REMENYITITL STRUCTURAL MECHANISM FOR THE SPECIFIC ASSEMBLY ANDTITL 2 ACTIVATION OF THE EXTRACELLULAR SIGNAL REGULATED KINASE 5TITL 3 (ERK5) MODULE.REF J.BIOL.CHEM. V. 288 8596 2013REFN ISSN 0021-9258PMID 23382384DOI 10.1074/JBC.M113.452235 Variant Set Distributions Mapped Variants
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 2nyl PPP2R5C crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated 3.8Å AUTH Y.XU,Y.XING,Y.CHEN,Y.CHAO,Z.LIN,E.FAN,J.W.YU,S.STRACK,AUTH 2 P.D.JEFFREY,Y.SHITITL STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYME.REF CELL(CAMBRIDGE,MASS.) V. 127 1239 2006REFN ISSN 0092-8674PMID 17174897DOI 10.1016/J.CELL.2006.11.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yc0 HGFAC short form hgfa with first kunitz domain from hai-1 2.6Å AUTH S.SHIA,J.STAMOS,D.KIRCHHOFER,B.FAN,J.WU,R.T.CORPUZ,AUTH 2 L.SANTELL,R.A.LAZARUS,C.EIGENBROTTITL CONFORMATIONAL LABILITY IN SERINE PROTEASE ACTIVE SITES:TITL 2 STRUCTURES OF HEPATOCYTE GROWTH FACTOR ACTIVATOR (HGFA)TITL 3 ALONE AND WITH THE INHIBITORY DOMAIN FROM HGFA INHIBITOR-1B.REF J.MOL.BIOL. V. 346 1335 2005REFN ISSN 0022-2836PMID 15713485DOI 10.1016/J.JMB.2004.12.048 Variant Set […]
General Structure Information 3rl8 DLG1 crytal structure of hdlg1-pdz2 complexed with apc 2.2Å AUTH Z.ZHANG,H.LI,L.CHEN,X.LU,J.ZHANG,P.XU,K.LIN,G.WUTITL MOLECULAR BASIS FOR THE RECOGNITION OF ADENOMATOUS POLYPOSISTITL 2 COLI BY THE DISCS LARGE 1 PROTEIN.REF PLOS ONE V. 6 23507 2011REFN ESSN 1932-6203PMID 21858148DOI 10.1371/JOURNAL.PONE.0023507 Variant Set Distributions Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2la5 FMR1 rna duplex-quadruplex junction complex with fmrp rgg peptide -1.0Å AUTH A.T.PHAN,V.KURYAVYI,J.C.DARNELL,A.SERGANOV,A.MAJUMDAR,AUTH 2 S.ILIN,T.RASLIN,A.POLONSKAIA,C.CHEN,D.CLAIN,R.B.DARNELL,AUTH 3 D.J.PATELTITL STRUCTURE-FUNCTION STUDIES OF FMRP RGG PEPTIDE RECOGNITIONTITL 2 OF AN RNA DUPLEX-QUADRUPLEX JUNCTION.REF NAT.STRUCT.MOL.BIOL. V. 18 796 2011REFN ISSN 1545-9993PMID 21642970DOI 10.1038/NSMB.2064 Variant Set Distributions Mapped Variants