Assessment of Structural Intolerance and Durability
General Structure Information 3aca NUDT5 crystal structure of human nudt5 complexed with 8-oxo-dadp and manganese 2.05Å AUTH T.ARIMORI,H.TAMAOKI,T.NAKAMURA,H.KAMIYA,S.IKEMIZU,Y.TAKAGI,AUTH 2 T.ISHIBASHI,H.HARASHIMA,M.SEKIGUCHI,Y.YAMAGATATITL DIVERSE SUBSTRATE RECOGNITION AND HYDROLYSIS MECHANISMS OFTITL 2 HUMAN NUDT5REF NUCLEIC ACIDS RES. V. 39 8972 2011REFN ISSN 0305-1048PMID 21768126DOI 10.1093/NAR/GKR575 Variant Set Distributions Mapped Variants
General Structure Information 4dxt SUN2 human sun2 (aa 522-717) 2.22Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3uoa MALT1 crystal structure of the malt1 paracaspase (p21 form) 1.75Å AUTH J.W.YU,P.D.JEFFREY,J.Y.HA,X.YANG,Y.SHITITL CRYSTAL STRUCTURE OF THE MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 2 LYMPHOMA TRANSLOCATION 1 (MALT1) PARACASPASE REGION.REF PROC.NATL.ACAD.SCI.USA V. 108 21004 2011REFN ISSN 0027-8424PMID 22158899DOI 10.1073/PNAS.1111708108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rip TUBGCP4 crystal structure of human gamma-tubulin complex protein 4 (gcp4) 2.3Å AUTH V.GUILLET,M.KNIBIEHLER,L.GREGORY-PAURON,M.H.REMY,C.CHEMIN,AUTH 2 B.RAYNAUD-MESSINA,C.BON,J.M.KOLLMAN,D.A.AGARD,A.MERDES,AUTH 3 L.MOUREYTITL CRYSTAL STRUCTURE OF GAMMA-TUBULIN COMPLEX PROTEIN GCP4TITL 2 PROVIDES INSIGHT INTO MICROTUBULE NUCLEATION.REF NAT.STRUCT.MOL.BIOL. V. 18 915 2011REFN ISSN 1545-9993PMID 21725292DOI 10.1038/NSMB.2083 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2lkm MORF4L1 structural basis for molecular interactions involving mrg domains: implications in chromatin biology -1.0Å AUTH T.XIE,R.GRAVELINE,G.S.KUMAR,Y.ZHANG,A.KRISHNAN,G.DAVID,AUTH 2 I.RADHAKRISHNANTITL STRUCTURAL BASIS FOR MOLECULAR INTERACTIONS INVOLVING MRGTITL 2 DOMAINS: IMPLICATIONS IN CHROMATIN BIOLOGY.REF STRUCTURE V. 20 151 2012REFN ISSN 0969-2126PMID 22244764DOI 10.1016/J.STR.2011.10.019 Variant Set Distributions Mapped Variants
General Structure Information 1wr6 GGA3 crystal structure of gga3 gat domain in complex with ubiquitin 2.6Å AUTH M.KAWASAKI,T.SHIBA,Y.SHIBA,Y.YAMAGUCHI,N.MATSUGAKI,AUTH 2 N.IGARASHI,M.SUZUKI,R.KATO,K.KATO,K.NAKAYAMA,AUTH 3 S.WAKATSUKITITL MOLECULAR MECHANISM OF UBIQUITIN RECOGNITION BYTITL 2 GGA3 GAT DOMAIN.REF GENES CELLS V. 10 639 2005REFN ISSN 1356-9597PMID 15966896DOI 10.1111/J.1365-2443.2005.00865.X Variant Set Distributions Mapped Variants
General Structure Information 1ue9 ITSN2 solution structure of the fourth sh3 domain of human intersectin 2 (kiaa1256) -1.0Å AUTH N.TOCHIO,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH SH3 DOMAIN OFTITL 2 HUMAN INTERSECTIN 2 (KIAA1256)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ujk GGA1 vhs domain of human gga1 complexed with c-terminal phosphopeptide from bace 1.9Å AUTH T.SHIBA,S.KAMETAKA,M.KAWASAKI,M.SHIBATA,S.WAGURI,AUTH 2 Y.UCHIYAMA,S.WAKATSUKITITL INSIGHTS INTO THE PHOSPHOREGULATION OFTITL 2 BETA-SECRETASE SORTING SIGNAL BY THE VHS DOMAIN OFTITL 3 GGA1REF TRAFFIC V. 5 437 2004REFN ISSN 1398-9219PMID 15117318DOI 10.1111/J.1600-0854.2004.00188.X Variant Set Distributions Mapped Variants
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3b1u PADI4 crystal structure of human peptidylarginine deiminase 4 in complex with o-f-amidine 2.1Å AUTH C.P.CAUSEY,J.E.JONES,J.L.SLACK,D.KAMEI,L.E.JONES JR,AUTH 2 V.SUBRAMANIAN,B.KNUCKLEY,P.EBRAHIMI,A.A.CHUMANEVICH,Y.LUO,AUTH 3 H.HASHIMOTO,M.SATO,L.J.HOFSETH,P.R.THOMPSONTITL THE DEVELOPMENT OFTITL 2 N-ALPHA-(2-CARBOXYL)BENZOYL-N(5)-(2-FLUORO-1-IMINOETHYL)-L-TITL 3 ORNITHINE AMIDE (O-F-AMIDINE) ANDTITL 4 N-ALPHA-(2-CARBOXYL)BENZOYL-N(5)-(2-CHLORO-1-IMINOETHYL)-L-TITL 5 ORNITHINE AMIDE (O-CL-AMIDINE) AS SECOND GENERATION PROTEINTITL 6 ARGININE DEIMINASE (PAD) INHIBITORSREF J.MED.CHEM. V. 54 6919 2011REFN ISSN […]