Assessment of Structural Intolerance and Durability
General Structure Information 4mqf GABBR1 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist 2-hydroxysaclofen 2.22Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4h9p DAXX complex structure 3 of daxx/h3.3(sub5,g90a)/h4 2.2Å AUTH S.J.ELSASSER,H.HUANG,P.W.LEWIS,J.W.CHIN,D.C.ALLIS,D.J.PATELTITL DAXX CHAPERONE ENVELOPS AN H3.3/H4 DIMER DICTATINGTITL 2 H3.3-SPECIFIC READ OUTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3a8y BAG5 crystal structure of the complex between the bag5 bd5 and hsp70 nbd 2.3Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants
General Structure Information 3mop IRAK4 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 2err RBFOX1 nmr structure of the rna binding domain of human fox-1 in complex with ugcaugu -1.0Å AUTH S.D.AUWETER,R.FASAN,L.REYMOND,J.G.UNDERWOOD,AUTH 2 D.L.BLACK,S.PITSCH,F.H.ALLAINTITL MOLECULAR BASIS OF RNA RECOGNITION BY THE HUMANTITL 2 ALTERNATIVE SPLICING FACTOR FOX-1.REF EMBO J. V. 25 163 2006REFN ISSN 0261-4189PMID 16362037DOI 10.1038/SJ.EMBOJ.7600918 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4dhx ENY2 eny2:ganp complex 2.1Å AUTH D.JANI,S.LUTZ,E.HURT,R.A.LASKEY,M.STEWART,V.O.WICKRAMASINGHETITL FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE MAMMALIANTITL 2 TREX-2 COMPLEX THAT LINKS TRANSCRIPTION WITH NUCLEARTITL 3 MESSENGER RNA EXPORT.REF NUCLEIC ACIDS RES. V. 40 4562 2012REFN ISSN 0305-1048PMID 22307388DOI 10.1093/NAR/GKS059 Variant Set Distributions Mapped Variants
General Structure Information 3zyi LRRC4 netring2 in complex with ngl2 2.6Å AUTH E.SEIRADAKE,C.H.COLES,P.V.PERESTENKO,K.HARLOS,AUTH 2 R.A.J.MCILHINNEY,A.R.ARICESCU,E.Y.JONESTITL STRUCTURAL BASIS FOR CELL SURFACE PATTERNING THROUGHTITL 2 NETRING-NGL INTERACTIONSREF EMBO J. V. 30 4479 2011REFN ISSN 0261-4189PMID 21946559DOI 10.1038/EMBOJ.2011.346 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ua9 TNKS2 crystal structure of human tankyrase 2 in complex with a selective inhibitor 2.15Å AUTH M.NARWAL,H.VENKANNAGARI,L.LEHTIOTITL STRUCTURAL BASIS OF SELECTIVE INHIBITION OF HUMANTITL 2 TANKYRASES.REF J.MED.CHEM. V. 55 1360 2012REFN ISSN 0022-2623PMID 22233320DOI 10.1021/JM201510P Variant Set Distributions Mapped Variants
General Structure Information 4day RMI1 crystal structure of the rmi core complex with mm2 peptide from fancm 3.3Å AUTH K.A.HOADLEY,Y.XUE,C.LING,M.TAKATA,W.WANG,J.L.KECKTITL DEFINING THE MOLECULAR INTERFACE THAT CONNECTS THE FANCONITITL 2 ANEMIA PROTEIN FANCM TO THE BLOOM SYNDROME DISSOLVASOME.REF PROC.NATL.ACAD.SCI.USA V. 109 4437 2012REFN ISSN 0027-8424PMID 22392978DOI 10.1073/PNAS.1117279109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants