Assessment of Structural Intolerance and Durability
General Structure Information 4doh IL20 il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q2g ADAMTS1 adamts1 in complex with a novel n-hydroxyformamide inhibitors 2.3Å AUTH C.DE SAVI,A.PAPE,J.G.CUMMING,A.TING,P.D.SMITH,J.N.BURROWS,AUTH 2 M.MILLS,C.DAVIES,S.LAMONT,D.MILNE,C.COOK,P.MOORE,Y.SAWYER,AUTH 3 S.GERHARDTTITL THE DESIGN AND SYNTHESIS OF NOVEL N-HYDROXYFORMAMIDETITL 2 INHIBITORS OF ADAM-TS4 FOR THE TREATMENT OF OSTEOARTHRITISREF BIOORG.MED.CHEM.LETT. V. 21 1376 2011REFN ISSN 0960-894XPMID 21300546DOI 10.1016/J.BMCL.2011.01.036 Variant Set Distributions Mapped Variants
General Structure Information 4im0 TBK1 structure of tank-binding kinase 1 2.4Å AUTH D.TU,Z.ZHU,A.Y.ZHOU,C.YUN,K.LEE,A.V.TOMS,Y.LI,G.P.DUNN,AUTH 2 E.CHAN,T.THAI,S.YANG,S.B.FICARRO,J.A.MARTO,H.JEON,W.C.HAHN,AUTH 3 D.A.BARBIE,M.J.ECKTITL STRUCTURE OF TANK-BINDING KINASE 1REF CELL.REPORTS. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bld SUFU crystal structure of a human suppressor of fused (sufu)- gli3p complex 2.8Å AUTH A.L.CHERRY,C.FINTA,M.KARLSTROM,Q.JIN,T.SCHWEND,AUTH 2 J.ASTORGA-WELLS,R.A.ZUBAREV,M.DEL CAMPO,A.R.CRISWELL,AUTH 3 D.DE SANCTIS,L.JOVINE,R.TOFTGARDTITL STRUCTURAL BASIS OF SUFU-GLI INTERACTION IN HEDGEHOGTITL 2 SIGNALLING REGULATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2579 2013REFN ISSN 0907-4449PMID 24311597DOI 10.1107/S0907444913028473 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3qmc CXXC1 structural basis of selective binding of nonmethylated cpg islands by the cxxc domain of cfp1 2.1Å AUTH C.XU,C.BIAN,R.LAM,A.DONG,J.MINTITL THE STRUCTURAL BASIS FOR SELECTIVE BINDING OF NON-METHYLATEDTITL 2 CPG ISLANDS BY THE CFP1 CXXC DOMAIN.REF NAT COMMUN V. 2 227 2011REFN ESSN 2041-1723PMID 21407193DOI 10.1038/NCOMMS1237 Variant Set Distributions Mapped Variants
General Structure Information 1×86 ARHGEF12 crystal structure of the dh/ph domains of leukemia-associated rhogef in complex with rhoa 3.22Å AUTH R.KRISTELLY,G.GAO,J.J.TESMERTITL STRUCTURAL DETERMINANTS OF RHOA BINDING AND NUCLEOTIDETITL 2 EXCHANGE IN LEUKEMIA-ASSOCIATED RHO GUANINE-NUCLEOTIDETITL 3 EXCHANGE FACTOR.REF J.BIOL.CHEM. V. 279 47352 2004REFN ISSN 0021-9258PMID 15331592DOI 10.1074/JBC.M406056200 Variant Set Distributions Mapped Variants
General Structure Information 2kxc BAIAP2L1 1h, 13c, and 15n chemical shift assignments for irtks-sh3 and espfu- r47 complex -1.0Å AUTH O.AITIO,M.HELLMAN,A.KAZLAUSKAS,D.F.VINGADASSALOM,J.M.LEONG,AUTH 2 K.SAKSELA,P.PERMITITL RECOGNITION OF TANDEM PXXP MOTIFS AS A UNIQUE SRC HOMOLOGYTITL 2 3-BINDING MODE TRIGGERS PATHOGEN-DRIVEN ACTIN ASSEMBLYREF PROC.NATL.ACAD.SCI.USA V. 107 21743 2010REFN ISSN 0027-8424PMID 21098279DOI 10.1073/PNAS.1010243107 Variant Set Distributions Mapped Variants
General Structure Information 4lad AMFR crystal structure of the ube2g2:ring-g2br complex 2.3Å AUTH R.DAS,Y.H.LIANG,J.MARIANO,J.LI,T.HUANG,A.KING,S.G.TARASOV,AUTH 2 A.M.WEISSMAN,X.JI,R.A.BYRDTITL ALLOSTERIC REGULATION OF E2:E3 INTERACTIONS PROMOTE ATITL 2 PROCESSIVE UBIQUITINATION MACHINE.REF EMBO J. V. 32 2504 2013REFN ISSN 0261-4189PMID 23942235DOI 10.1038/EMBOJ.2013.174 Variant Set Distributions Mapped Variants
General Structure Information 3gv7 POLI human dna polymerase iota in complex with t template dna and incoming dttp 2.2Å AUTH K.N.KIROUAC,H.LINGTITL STRUCTURAL BASIS OF ERROR-PRONE REPLICATION AND STALLING ATTITL 2 A THYMINE BASE BY HUMAN DNA POLYMERASE IOTAREF EMBO J. V. 28 1644 2009REFN ISSN 0261-4189PMID 19440206DOI 10.1038/EMBOJ.2009.122 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2z5k NXF1 complex of transportin 1 with tap nls 2.6Å AUTH T.IMASAKI,T.SHIMIZU,H.HASHIMOTO,Y.HIDAKA,S.KOSE,N.IMAMOTO,AUTH 2 M.YAMADA,M.SATOTITL STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION AND DISSOCIATIONTITL 2 BY HUMAN TRANSPORTIN 1REF MOL.CELL V. 28 57 2007REFN ISSN 1097-2765PMID 17936704DOI 10.1016/J.MOLCEL.2007.08.006 Variant Set Distributions Mapped Variants