Assessment of Structural Intolerance and Durability
General Structure Information 3hl2 SEPSECS the crystal structure of the human sepsecs-trnasec complex 2.81Å AUTH S.PALIOURA,R.L.SHERRER,T.A.STEITZ,D.SOLL,AUTH 2 M.SIMONOVICTITL THE HUMAN SEPSECS-TRNASEC COMPLEX REVEALS THETITL 2 MECHANISM OF SELENOCYSTEINE FORMATION.REF SCIENCE V. 325 321 2009REFN ISSN 0036-8075PMID 19608919DOI 10.1126/SCIENCE.1173755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3t6j DPP3 structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0 angstroms 2.98Å AUTH G.A.BEZERRA,E.DOBROVETSKY,R.VIERTLMAYR,A.DONG,A.BINTER,AUTH 2 M.ABRAMIC,P.MACHEROUX,S.DHE-PAGANON,K.GRUBERTITL ENTROPY-DRIVEN BINDING OF OPIOID PEPTIDES INDUCES A LARGETITL 2 DOMAIN MOTION IN HUMAN DIPEPTIDYL PEPTIDASE III.REF PROC.NATL.ACAD.SCI.USA V. 109 6525 2012REFN ISSN 0027-8424PMID 22493238DOI 10.1073/PNAS.1118005109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2io1 SENP2 crystal structure of human senp2 in complex with presumo-3 2.6Å AUTH D.REVERTER,C.D.LIMATITL STRUCTURAL BASIS FOR SENP2 PROTEASE INTERACTIONSTITL 2 WITH SUMO PRECURSORS AND CONJUGATED SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 13 1060 2006REFN ISSN 1545-9993PMID 17099700DOI 10.1038/NSMB1168 Variant Set Distributions Mapped Variants
General Structure Information 2fe4 RAB6B the crystal structure of human neuronal rab6b in its inactive gdp-bound form 2.3Å AUTH I.GARCIA-SAEZ,S.TCHERNIUK,F.KOZIELSKITITL THE STRUCTURE OF HUMAN NEURONAL RAB6B IN THETITL 2 ACTIVE AND INACTIVE FORM.REF ACTA CRYSTALLOGR.,SECT.D V. 62 725 2006REFN ISSN 0907-4449PMID 16790928DOI 10.1107/S0907444906015319 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3bc1 SYTL2 crystal structure of the complex rab27a-slp2a 1.8Å AUTH L.M.G.CHAVAS,K.IHARA,M.KAWASAKI,S.TORII,T.UEJIMA,R.KATO,AUTH 2 T.IZUMI,S.WAKATSUKITITL ELUCIDATION OF RAB27 RECRUITMENT BY ITS EFFECTORS: STRUCTURETITL 2 OF RAB27A BOUND TO EXOPHILIN4/SLP2-AREF STRUCTURE V. 16 1468 2008REFN ISSN 0969-2126PMID 18940603DOI 10.1016/J.STR.2008.07.015 Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC5 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2nn6 EXOSC4 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Mapped Variants
General Structure Information 3o4o IL1RAP crystal structure of an interleukin-1 receptor complex 3.3Å AUTH D.L.WANG,S.Y.ZHANG,L.LI,X.LIU,K.R.MEI,X.Q.WANGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND ACTIVATION OFTITL 2 IL-1BETA WITH ITS RECEPTORSREF NAT.IMMUNOL. V. 11 905 2010REFN ISSN 1529-2908PMID 20802483DOI 10.1038/NI.1925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y96 GEMIN7 crystal structure of the gemin6/gemin7 heterodimer from the human smn complex 2.0Å AUTH Y.MA,J.DOSTIE,G.DREYFUSS,G.D.VAN DUYNETITL THE GEMIN6-GEMIN7 HETERODIMER FROM THE SURVIVAL OFTITL 2 MOTOR NEURONS COMPLEX HAS AN SM PROTEIN-LIKETITL 3 STRUCTURE.REF STRUCTURE V. 13 883 2005REFN ISSN 0969-2126PMID 15939020DOI 10.1016/J.STR.2005.03.014 Variant Set Distributions Mapped Variants
General Structure Information 2li8 LIN28A the solution structure of the lin28-znf domains bound to aggagau of pre-let-7 mirna -1.0Å AUTH F.E.LOUGHLIN,L.F.GEBERT,H.TOWBIN,A.BRUNSCHWEIGER,J.HALL,AUTH 2 F.H.ALLAINTITL STRUCTURAL BASIS OF PRE-LET-7 MIRNA RECOGNITION BY THE ZINCTITL 2 KNUCKLES OF PLURIPOTENCY FACTOR LIN28.REF NAT.STRUCT.MOL.BIOL. V. 19 84 2011REFN ISSN 1545-9993PMID 22157959DOI 10.1038/NSMB.2202 Variant Set Distributions Mapped Variants