Assessment of Structural Intolerance and Durability
General Structure Information 4bgq CDKL5 crystal structure of the human cdkl5 kinase domain 2.0Å AUTH P.CANNING,T.KROJER,S.GOUBIN,P.MAHAJAN,M.VOLLMAR,A.C.W.PIKE,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN CDKL5 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dg6 LRP6 crystal structure of domains 1 and 2 of lrp6 2.9Å AUTH G.HOLDSWORTH,P.SLOCOMBE,C.DOYLE,B.SWEENEY,V.VEVERKA,AUTH 2 K.LE RICH,R.J.FRANKLIN,D.BROOKINGS,J.TURNER,J.KENNEDY,AUTH 3 R.GARLISH,J.SHI,L.NEWNHAM,D.MCMILLAN,M.MUZYLAK,M.CARR,AUTH 4 A.J.HENRY,T.CESKA,M.K.ROBINSONTITL CHARACTERIZATION OF THE INTERACTION OF SCLEROSTIN WITH THETITL 2 LRP FAMILY OF WNT CO-RECEPTORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2i4i DDX3X crystal structure of human dead-box rna helicase ddx3x 2.2Å AUTH M.HOGBOM,R.COLLINS,S.VAN DEN BERG,R.-M.JENVERT,T.KARLBERG,AUTH 2 T.KOTENYOVA,A.FLORES,G.B.KARLSSON HEDESTAM,AUTH 3 L.H.HOLMBERG SCHIAVONETITL CRYSTAL STRUCTURE OF CONSERVED DOMAINS 1 AND 2 OF THE HUMANTITL 2 DEAD-BOX HELICASE DDX3X IN COMPLEX WITH THE MONONUCLEOTIDETITL 3 AMPREF J.MOL.BIOL. V. 372 150 2007REFN ISSN 0022-2836PMID 17631897DOI 10.1016/J.JMB.2007.06.050 […]
General Structure Information 3urf TNFRSF11B human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4aif AIP aip tpr domain in complex with human hsp90 peptide 2.01Å AUTH R.M.MORGAN,L.C.HERNANDEZ-RAMIREZ,G.TRIVELLIN,L.ZHOU,S.M.ROE,AUTH 2 M.KORBONITS,C.PRODROMOUTITL STRUCTURE OF THE TPR DOMAIN OF AIP: LACK OF CLIENT PROTEINTITL 2 INTERACTION WITH THE C-TERMINAL ALPHA-7 HELIX OF THE TPRTITL 3 DOMAIN OF AIP IS SUFFICIENT FOR PITUITARY ADENOMATITL 4 PREDISPOSITION.REF PLOS ONE V. 7 […]
General Structure Information 3ee6 TPP1 crystal structure analysis of tripeptidyl peptidase -i 2.35Å AUTH A.PAL,R.KRAETZNER,T.GRUENE,M.GRAPP,K.SCHREIBER,M.GRONBORG,AUTH 2 H.URLAUB,S.BECKER,A.R.ASIF,J.GARTNER,G.M.SHELDRICK,AUTH 3 R.STEINFELDTITL STRUCTURE OF TRIPEPTIDYL-PEPTIDASE I PROVIDES INSIGHT INTOTITL 2 THE MOLECULAR BASIS OF LATE INFANTILE NEURONAL CEROIDTITL 3 LIPOFUSCINOSISREF J.BIOL.CHEM. V. 284 3976 2009REFN ISSN 0021-9258PMID 19038966DOI 10.1074/JBC.M806947200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3mdy BMPR1B crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189 2.05Å AUTH A.CHAIKUAD,C.SANVITALE,P.MAHAJAN,N.DAGA,C.COOPER,T.KROJER,AUTH 2 I.ALFANO,S.KNAPP,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,A.BULLOCK,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONETITL 2 MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN […]
General Structure Information 2lkn AIP solution structure of the ppiase domain of human aryl-hydrocarbon receptor-interacting protein (aip) -1.0Å AUTH M.LINNERT,Y.J.LIN,A.MANNS,K.HAUPT,A.K.PASCHKE,G.FISCHER,AUTH 2 M.WEIWAD,C.LUECKETITL THE FKBP-TYPE DOMAIN OF THE HUMAN ARYL HYDROCARBONTITL 2 RECEPTOR-INTERACTING PROTEIN REVEALS AN UNUSUAL HSP90TITL 3 INTERACTION.REF BIOCHEMISTRY V. 52 2097 2013REFN ISSN 0006-2960PMID 23418784DOI 10.1021/BI301649M Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4og5 MEN1 human menin with bound inhibitor miv-5 1.63Å AUTH S.HE,T.J.SENTER,J.POLLOCK,C.HAN,S.K.UPADHYAY,T.PUROHIT,AUTH 2 R.D.GOGLIOTTI,C.W.LINDSLEY,T.CIERPICKI,S.R.STAUFFER,AUTH 3 J.GREMBECKATITL HIGH-AFFINITY SMALL-MOLECULE INHIBITORS OF THE MENIN-MIXEDTITL 2 LINEAGE LEUKEMIA (MLL) INTERACTION CLOSELY MIMIC A NATURALTITL 3 PROTEIN-PROTEIN INTERACTION.REF J.MED.CHEM. V. 57 1543 2014REFN ISSN 0022-2623PMID 24472025DOI 10.1021/JM401868D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2fim TULP1 structure of the c-terminal domain of human tubby-like protein 1 1.9Å AUTH C.PERSSON,D.OGG,A.G.THORSELL,C.ARROWSMITH,H.BERGLUND,AUTH 2 A.EDWARDS,M.EHN,S.FLODIN,S.GRASLUND,M.HAMMARSTROM,M.HOGBOM,AUTH 3 L.HOLMBERG-SCHIAVONE,T.KOTENYOVA,P.KURSULA,P.NILSSON-EHLE,AUTH 4 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 5 S.VAN DEN BERG,J.WEIGELT,B.M.HALLBERGTITL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKETITL 2 PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants