Assessment of Structural Intolerance and Durability
General Structure Information 3rhk MET crystal structure of the catalytic domain of c-met kinase in complex with arq 197 1.94Å AUTH S.EATHIRAJ,R.PALMA,E.VOLCKOVA,M.HIRSCHI,D.S.FRANCE,AUTH 2 M.A.ASHWELL,T.C.CHANTITL DISCOVERY OF A NOVEL MODE OF PROTEIN KINASE INHIBITIONTITL 2 CHARACTERIZED BY THE MECHANISM OF INHIBITION OF HUMANTITL 3 MESENCHYMAL-EPITHELIAL TRANSITION FACTOR (C-MET) PROTEINTITL 4 AUTOPHOSPHORYLATION BY ARQ 197.REF J.BIOL.CHEM. V. […]
General Structure Information 2x2u RET first two cadherin-like domains from human ret 2.0Å AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1t2f LDHB human b lactate dehydrogenase complexed with nad+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid 3.0Å AUTH A.CAMERON,J.READ,R.TRANTER,V.J.WINTER,R.B.SESSIONS,AUTH 2 R.L.BRADY,L.VIVAS,A.EASTON,H.KENDRICK,S.L.CROFT,AUTH 3 D.BARROS,J.L.LAVANDERA,J.J.MARTIN,F.RISCO,AUTH 4 S.GARCIA-OCHOA,F.J.GAMO,L.SANZ,L.LEON,J.R.RUIZ,AUTH 5 R.GABARRO,A.MALLO,F.G.DE LAS HERASTITL IDENTIFICATION AND ACTIVITY OF A SERIES OFTITL 2 AZOLE-BASED COMPOUNDS WITH LACTATETITL 3 DEHYDROGENASE-DIRECTED ANTI-MALARIAL ACTIVITY.REF J.BIOL.CHEM. V. 279 31429 2004REFN ISSN 0021-9258PMID 15117937DOI 10.1074/JBC.M402433200 Variant […]
General Structure Information 2y5l FBP1 orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase 2.2Å AUTH P.HEBEISEN,W.HAAP,B.KUHN,P.MOHR,H.P.WESSEL,U.ZUTTER,AUTH 2 S.KIRCHNER,A.RUF,J.BENZ,C.JOSEPH,R.ALVAREZ-SANCHEZ,M.GUBLER,AUTH 3 B.SCHOTT,A.BENARDEAU,E.TOZZO,E.KITASTITL ORALLY ACTIVE AMINOPYRIDINES AS INHIBITORS OF TETRAMERICTITL 2 FRUCTOSE-1,6-BISPHOSPHATASE.REF BIOORG.MED.CHEM.LETT. V. 21 3237 2011REFN ISSN 0960-894XPMID 21550236DOI 10.1016/J.BMCL.2011.04.044 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2aa6 NR3C2 mineralocorticoid receptor s810l mutant with bound progesterone 1.95Å AUTH R.K.BLEDSOE,K.P.MADAUSS,J.A.HOLT,C.J.APOLITO,AUTH 2 M.H.LAMBERT,K.H.PEARCE,T.B.STANLEY,E.L.STEWART,AUTH 3 R.P.TRUMP,T.M.WILLSON,S.P.WILLIAMSTITL A LIGAND-MEDIATED HYDROGEN BOND NETWORK REQUIREDTITL 2 FOR THE ACTIVATION OF THE MINERALOCORTICOIDTITL 3 RECEPTORREF J.BIOL.CHEM. V. 280 31283 2005REFN ISSN 0021-9258PMID 15967794DOI 10.1074/JBC.M504098200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1kb4 VDR crystal structure of vdr dna-binding domain bound to a canonical direct repeat with three base pair spacer (dr3) response element 2.8Å AUTH P.L.SHAFFER,D.T.GEWIRTHTITL STRUCTURAL BASIS OF VDR-DNA INTERACTIONS ON DIRECTTITL 2 REPEAT RESPONSE ELEMENTS.REF EMBO J. V. 21 2242 2002REFN ISSN 0261-4189PMID 11980721DOI 10.1093/EMBOJ/21.9.2242 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 1zmd DLD crystal structure of human dihydrolipoamide dehydrogenase complexed to nadh 2.08Å AUTH C.A.BRAUTIGAM,J.L.CHUANG,D.R.TOMCHICK,M.MACHIUS,AUTH 2 D.T.CHUANGTITL CRYSTAL STRUCTURE OF HUMAN DIHYDROLIPOAMIDETITL 2 DEHYDROGENASE: NAD+/NADH BINDING AND THETITL 3 STRUCTURAL BASIS OF DISEASE-CAUSING MUTATIONSREF J.MOL.BIOL. V. 350 543 2005REFN ISSN 0022-2836PMID 15946682DOI 10.1016/J.JMB.2005.05.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1cvs FGFR1 crystal structure of a dimeric fgf2-fgfr1 complex 2.8Å AUTH A.N.PLOTNIKOV,J.SCHLESSINGER,S.R.HUBBARD,AUTH 2 M.MOHAMMADITITL STRUCTURAL BASIS FOR FGF RECEPTOR DIMERIZATION ANDTITL 2 ACTIVATION.REF CELL(CAMBRIDGE,MASS.) V. 98 641 1999REFN ISSN 0092-8674PMID 10490103DOI 10.1016/S0092-8674(00)80051-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3th4 F7 mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+ 1.8Å AUTH K.VADIVEL,S.AGAH,A.MESSER,D.CASCIO,S.M.BAJAJ,S.KRISHNASWAMY,AUTH 2 C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THETITL 2 GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMINTITL 3 K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+REF TO BE PUBLISHEDREFN […]
General Structure Information 2wsl BCHE aged form of human butyrylcholinesterase inhibited by tabun analogue ta4 2.0Å AUTH E.CARLETTI,N.AURBEK,E.GILLON,M.LOIODICE,Y.NICOLET,AUTH 2 J.C.FONTECILLA-CAMPS,P.MASSON,H.THIERMANN,F.NACHON,F.WOREKTITL STRUCTURE-ACTIVITY ANALYSIS OF AGING AND REACTIVATION OFTITL 2 HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY ANALOGUES OFTITL 3 TABUN.REF BIOCHEM.J. V. 421 97 2009REFN ISSN 0264-6021PMID 19368529DOI 10.1042/BJ20090091 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]