Assessment of Structural Intolerance and Durability
General Structure Information 2hb8 VDR crystal structure of vdr lbd in complex with 2alpha-methyl calcitriol 2.0Å AUTH S.HOURAI,T.FUJISHIMA,A.KITTAKA,Y.SUHARA,H.TAKAYAMA,AUTH 2 N.ROCHEL,D.MORASTITL PROBING A WATER CHANNEL NEAR THE A-RING OFTITL 2 RECEPTOR-BOUND 1ALPHA,25-DIHYDROXYVITAMIN D3 WITHTITL 3 SELECTED 2ALPHA-SUBSTITUTED ANALOGUESREF J.MED.CHEM. V. 49 5199 2006REFN ISSN 0022-2623PMID 16913708DOI 10.1021/JM0604070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]
General Structure Information 3gw3 UROD human urod mutant k297n 1.7Å AUTH C.A.WARBY,J.D.PHILLIPS,H.A.BERGONIA,F.G.WHITBY,C.P.HILL,AUTH 2 J.P.KUSHNERTITL STRUCTURAL AND KINETIC CHARACTERIZATION OF MUTANT HUMANTITL 2 UROPORPHYRINOGEN DECARBOXYLASES.REF CELL MOL BIOL V. 55 40 2009REF 2 (NOISY-LE-GRAND)REFNPMID 19656450 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lxc GLA interconversion of human lysosomal enzyme specificities 2.35Å AUTH I.B.TOMASIC,M.C.METCALF,A.I.GUCE,N.E.CLARK,S.C.GARMANTITL INTERCONVERSION OF THE SPECIFICITIES OF HUMAN LYSOSOMALTITL 2 ENZYMES ASSOCIATED WITH FABRY AND SCHINDLER DISEASES.REF J.BIOL.CHEM. V. 285 21560 2010REFN ISSN 0021-9258PMID 20444686DOI 10.1074/JBC.M110.118588 Variant Set Distributions Mapped Variants
General Structure Information 1hk0 CRYGD human gamma-d crystallin structure at 1.25 a resolution 1.25Å AUTH A.K.BASAK,O.BATEMAN,C.SLINGSBY,A.PANDE,N.ASHERIE,AUTH 2 O.OGUN,G.BENEDEK,J.PANDETITL HIGH-RESOLUTION X-RAY CRYSTAL STRUCTURES OF HUMANTITL 2 GAMMAD CRYSTALLIN (1.25A) AND THE R58H MUTANTTITL 3 (1.15A) ASSOCIATED WITH ACULEIFORM CATARACTREF J.MOL.BIOL. V. 328 1137 2003REFN ISSN 0022-2836PMID 12729747DOI 10.1016/S0022-2836(03)00375-9 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2xsn TH crystal structure of human tyrosine hydroxylase catalytic domain 2.68Å AUTH J.R.C.MUNIZ,C.D.O.COOPER,W.W.YUE,E.KRYSZTOFINSKA,AUTH 2 F.VON DELFT,S.KNAPP,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTICTITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1rrj TOP1 structural mechanisms of camptothecin resistance by mutations in human topoisomerase i 2.3Å AUTH J.E.CHRENCIK,B.L.STAKER,A.B.BURGIN,P.POURQUIER,AUTH 2 Y.POMMIER,L.STEWART,M.R.REDINBOTITL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY HUMANTITL 2 TOPOISOMERASE I MUTATIONSREF J.MOL.BIOL. V. 339 773 2004REFN ISSN 0022-2836PMID 15165849DOI 10.1016/J.JMB.2004.03.077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]
General Structure Information 3e04 FH crystal structure of human fumarate hydratase 1.95Å AUTH K.L.KAVANAGH,S.PICAUD,E.S.PILKA,W.W.YUE,A.K.ROOS,AUTH 2 P.FILIPPAKOPOULOS,F.VON DELFT,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN FUMARATE HYDRATASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants