Assessment of Structural Intolerance and Durability
General Structure Information 1p49 STS structure of human placental estrone/dhea sulfatase 2.6Å AUTH F.G.HERNANDEZ-GUZMAN,T.HIGASHIYAMA,W.PANGBORN,Y.OSAWA,AUTH 2 D.GHOSHTITL STRUCTURE OF HUMAN ESTRONE SULFATASE SUGGESTS FUNCTIONALTITL 2 ROLES OF MEMBRANE ASSOCIATIONREF J.BIOL.CHEM. V. 278 22989 2003REFN ISSN 0021-9258PMID 12657638DOI 10.1074/JBC.M211497200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2pip AR androgen receptor lbd with small molecule 1.8Å AUTH E.ESTEBANEZ-PERPINA,L.A.ARNOLD,A.A.ARNOLD,P.NGUYEN,AUTH 2 E.D.RODRIGUES,E.MAR,R.BATEMAN,P.PALLAI,K.M.SHOKAT,AUTH 3 J.D.BAXTER,R.K.GUY,P.WEBB,R.J.FLETTERICKTITL A SURFACE ON THE ANDROGEN RECEPTOR THATTITL 2 ALLOSTERICALLY REGULATES COACTIVATOR BINDING.REF PROC.NATL.ACAD.SCI.USA V. 104 16074 2007REFN ISSN 0027-8424PMID 17911242DOI 10.1073/PNAS.0708036104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2h4m HNRNPA1 karyopherin beta2/transportin-m9nls 3.05Å AUTH B.J.LEE,A.E.CANSIZOGLU,T.H.LOUIS,Z.ZHANG,Y.M.CHOOKTITL RULES FOR NUCLEAR LOCALIZATION SEQUENCETITL 2 RECOGNITION BY KARYOPHERIN BETA 2.REF CELL(CAMBRIDGE,MASS.) V. 126 543 2006REFN ISSN 0092-8674PMID 16901787DOI 10.1016/J.CELL.2006.05.049 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nq0 THRB tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd 2.4Å AUTH B.R.HUBER,M.DESCLOZEAUX,B.L.WEST,S.T.CUNHA-LIMA,H.T.NGUYEN,AUTH 2 J.D.BAXTER,H.A.INGRAHAM,R.J.FLETTERICKTITL THYROID HORMONE RECEPTOR-BETA MUTATIONS CONFERRING HORMONETITL 2 RESISTANCE AND REDUCED COREPRESSOR RELEASE EXHIBIT DECREASEDTITL 3 STABILITY IN THE N-TERMINAL LIGAND-BINDING DOMAINREF MOL.ENDOCRINOL. V. 17 107 2003REFN ISSN 0888-8809PMID […]
General Structure Information 1l5s PYGL human liver glycogen phosphorylase complexed with uric acid, n-acetyl- beta-d-glucopyranosylamine, and cp-403,700 2.1Å AUTH J.L.EKSTROM,T.A.PAULY,M.D.CARTY,W.C.SOELLER,J.CULP,AUTH 2 D.E.DANLEY,D.J.HOOVER,J.L.TREADWAY,E.M.GIBBS,R.J.FLETTERICK,AUTH 3 Y.S.DAY,D.G.MYSZKA,V.L.RATHTITL STRUCTURE-ACTIVITY ANALYSIS OF THE PURINE BINDING SITE OFTITL 2 HUMAN LIVER GLYCOGEN PHOSPHORYLASE.REF CHEM.BIOL. V. 9 915 2002REFN ISSN 1074-5521PMID 12204691DOI 10.1016/S1074-5521(02)00186-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1hdr QDPR the crystallographic structure of a human dihydropteridine reductase nadh binary complex expressed in escherichia coli by a cdna constructed from its rat homologue 2.5Å AUTH Y.SU,K.I.VARUGHESE,N.H.XUONG,T.L.BRAY,D.J.ROCHE,J.M.WHITELEYTITL THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINETITL 2 REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLITITL 3 BY A CDNA CONSTRUCTED FROM ITS RAT […]
General Structure Information 3bch RPSA crystal structure of the human laminin receptor precursor 2.15Å AUTH K.V.JAMIESON,J.WU,S.R.HUBBARD,D.MERUELOTITL CRYSTAL STRUCTURE OF THE HUMAN LAMININ RECEPTORTITL 2 PRECURSOR.REF J.BIOL.CHEM. V. 283 3002 2008REFN ISSN 0021-9258PMID 18063583DOI 10.1074/JBC.C700206200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z8d PYGM crystal structure of human muscle glycogen phosphorylase a with amp and glucose 2.3Å AUTH C.M.LUKACS,N.G.OIKONOMAKOS,R.L.CROWTHER,L.N.HONG,AUTH 2 R.U.KAMMLOTT,W.LEVIN,S.LI,C.M.LIU,D.LUCAS-MCGADY,AUTH 3 S.PIETRANICO,L.REIKTITL THE CRYSTAL STRUCTURE OF HUMAN MUSCLE GLYCOGEN PHOSPHORYLASETITL 2 A WITH BOUND GLUCOSE AND AMP: AN INTERMEDIATE CONFORMATIONTITL 3 WITH T-STATE AND R-STATE FEATURES.REF PROTEINS V. 63 1123 2006REFN ISSN 0887-3585PMID […]
General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]