Assessment of Structural Intolerance and Durability
General Structure Information 3uoa MALT1 crystal structure of the malt1 paracaspase (p21 form) 1.75Å AUTH J.W.YU,P.D.JEFFREY,J.Y.HA,X.YANG,Y.SHITITL CRYSTAL STRUCTURE OF THE MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 2 LYMPHOMA TRANSLOCATION 1 (MALT1) PARACASPASE REGION.REF PROC.NATL.ACAD.SCI.USA V. 108 21004 2011REFN ISSN 0027-8424PMID 22158899DOI 10.1073/PNAS.1111708108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1few DIABLO crystal structure of smac/diablo 2.2Å AUTH J.CHAI,C.DU,J.W.WU,S.KYIN,X.WANG,Y.SHITITL STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BYTITL 2 SMAC/DIABLO.REF NATURE V. 406 855 2000REFN ISSN 0028-0836PMID 10972280DOI 10.1038/35022514 Variant Set Distributions Mapped Variants
General Structure Information 1xb0 BIRC8 structure of the bir domain of iap-like protein 2 2.2Å AUTH H.SHIN,M.RENATUS,B.P.ECKELMAN,V.A.NUNES,AUTH 2 C.A.M.SAMPAIO,G.S.SALVESENTITL THE BIR DOMAIN OF IAP-LIKE PROTEIN 2 ISTITL 2 CONFORMATIONALLY UNSTABLE: IMPLICATIONS FORTITL 3 CASPASE INHIBITIONREF BIOCHEM.J. V. 385 1 2005REFN ISSN 0264-6021PMID 15485395DOI 10.1042/BJ20041107 Variant Set Distributions Mapped Variants
General Structure Information 1y02 RFFL crystal structure of a fyve-type domain from caspase regulator carp2 1.8Å AUTH M.D.TIBBETTS,E.N.SHIOZAKI,L.GU,E.R.MCDONALD,AUTH 2 W.S.EL-DEIRY,Y.SHITITL CRYSTAL STRUCTURE OF A FYVE-TYPE ZINC FINGERTITL 2 DOMAIN FROM THE CASPASE REGULATOR CARP2.REF STRUCTURE V. 12 2257 2004REFN ISSN 0969-2126PMID 15576038DOI 10.1016/J.STR.2004.10.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vgq MAVS crystal structure of human ips-1 card 2.1Å AUTH J.A.POTTER,R.E.RANDALL,G.L.TAYLORTITL CRYSTAL STRUCTURE OF HUMAN IPS-1 CASPASETITL 2 ACTIVATION RECRUITMENT DOMAINREF BMC STRUCT.BIOL. V. 8 11 2008REFN ISSN 1472-6807PMID 18307765DOI 10.1186/1472-6807-8-11 Variant Set Distributions Mapped Variants
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3crd CRADD nmr structure of the raidd card domain, 15 structures -1.0Å AUTH J.J.CHOU,H.MATSUO,H.DUAN,G.WAGNERTITL SOLUTION STRUCTURE OF THE RAIDD CARD AND MODEL FORTITL 2 CARD/CARD INTERACTION IN CASPASE-2 AND CASPASE-9TITL 3 RECRUITMENT.REF CELL(CAMBRIDGE,MASS.) V. 94 171 1998REFN ISSN 0092-8674PMID 9695946DOI 10.1016/S0092-8674(00)81417-8 Variant Set Distributions Mapped Variants
General Structure Information 3crd CRADD nmr structure of the raidd card domain, 15 structures -1.0Å AUTH J.J.CHOU,H.MATSUO,H.DUAN,G.WAGNERTITL SOLUTION STRUCTURE OF THE RAIDD CARD AND MODEL FORTITL 2 CARD/CARD INTERACTION IN CASPASE-2 AND CASPASE-9TITL 3 RECRUITMENT.REF CELL(CAMBRIDGE,MASS.) V. 94 171 1998REFN ISSN 0092-8674PMID 9695946DOI 10.1016/S0092-8674(00)81417-8 Variant Set Distributions Mapped Variants
General Structure Information 3v6m CASP6 inhibition of caspase-6 activity by single mutation outside the active site 2.69Å AUTH Q.CAO,X.J.WANG,C.W.LIU,D.F.LIU,L.F.LI,Y.Q.GAO,X.D.SUTITL INHIBITORY MECHANISM OF CASPASE-6 PHOSPHORYLATION REVEALEDTITL 2 BY CRYSTAL STRUCTURES, MOLECULAR DYNAMICS SIMULATIONS, ANDTITL 3 BIOCHEMICAL ASSAYSREF J.BIOL.CHEM. V. 287 15371 2012REFN ISSN 0021-9258PMID 22433863DOI 10.1074/JBC.M112.351213 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ygs CASP9 apaf-1 card in complex with prodomain of procaspase-9 2.5Å AUTH H.QIN,S.M.SRINIVASULA,G.WU,T.FERNANDES-ALNEMRI,AUTH 2 E.S.ALNEMRI,Y.SHITITL STRUCTURAL BASIS OF PROCASPASE-9 RECRUITMENT BYTITL 2 THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.REF NATURE V. 399 549 1999REFN ISSN 0028-0836PMID 10376594DOI 10.1038/21124 Variant Set Distributions Mapped Variants