2VGQ.A | MAVS – ASTRID

2VGQ.A | MAVS

General Structure Information

PDB ID	2vgq
HGNC Gene Label(s)	MAVS
Structure Name	crystal structure of human ips-1 card
Resolution	2.1Å
Reference	AUTH J.A.POTTER,R.E.RANDALL,G.L.TAYLORTITL CRYSTAL STRUCTURE OF HUMAN IPS-1 CASPASETITL 2 ACTIVATION RECRUITMENT DOMAINREF BMC STRUCT.BIOL. V. 8 11 2008REFN ISSN 1472-6807PMID 18307765DOI 10.1186/1472-6807-8-11

Variant Set Distributions

ExAC Variants

Number Of Residues	93
Number Of SNVs	35
Number Of Permutations	4940
Optimal Distance Threshold	7.0
K Statistic	0.069
p-value	0.505

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
20:3835275		P>S	A:371	(-30.88, 26.31, 18.75)
20:3835276	rs201109202	P>L	A:371	(-30.88, 26.31, 18.75)
20:3835290		K>E	A:376	(-39.18, 22.93, 18.08)
20:3835294	rs139701251	T>I	A:377	(-40.08, 27.12, 16.01)
20:3835296	rs555787558	Y>D	A:378	(-37.93, 27.11, 10.10)
20:3835305		I>V	A:381	(-43.38, 27.80, 10.99)
20:3835307		I>M	A:381	(-43.38, 27.80, 10.99)
20:3835312		R>H	A:383	(-43.26, 20.17, 9.28)
20:3835315	rs569887649	N>S	A:384	(-47.88, 24.02, 10.47)
20:3835323		N>H	A:387	(-51.58, 27.81, 10.35)
20:3835324		N>S	A:387	(-51.58, 27.81, 10.35)
20:3835338		D>H	A:392	(-49.00, 41.21, 5.69)
20:3835362		L>M	A:400	(-39.28, 41.87, 12.62)
20:3835383		D>N	A:407	(-33.11, 41.31, 5.41)
20:3838286	rs200238521 COSM4098349	R>Q	A:410	(-34.05, 40.21, 0.73)
20:3838291	rs149764765	R>W	A:412	(-40.14, 45.84, 1.60)
20:3838294	COSM1026762	A>S	A:413	(-38.86, 42.66, -3.73)
20:3838298		T>I	A:414	(-39.82, 39.01, -2.89)
20:3838303	rs375715742	T>S	A:416	(-43.08, 43.28, -5.77)
20:3838313		G>E	A:419	(-45.96, 37.73, -3.25)
20:3838318	rs370970889	R>W	A:421	(-48.66, 31.51, 0.18)
20:3838321	rs375662718	D>N	A:422	(-44.36, 32.92, -2.48)
20:3838334		H>R	A:426	(-38.24, 33.66, 0.97)
20:3838337		L>R	A:427	(-40.08, 36.15, 6.57)
20:3838345		T>A	A:430	(-34.45, 35.41, 6.71)
20:3838355	rs200408454	R>Q	A:433	(-30.69, 33.48, 7.80)
20:3838357	rs78448735	R>W	A:434	(-30.87, 36.86, 10.86)
20:3838358		R>Q	A:434	(-30.87, 36.86, 10.86)
20:3838363	rs142867936	G>S	A:436	(-34.03, 36.60, 18.34)
20:3838369	COSM1026763	V>L	A:438	(-38.85, 33.51, 18.23)
20:3838374		E>D	A:439	(-38.24, 36.20, 21.26)
20:3838382		I>T	A:442	(-44.03, 36.05, 19.61)
20:3838385	rs201308621	A>V	A:443	(-44.28, 40.42, 18.90)
20:3838396	rs370773994	G>S	A:447	(-49.14, 43.57, 16.57)
20:3838399	rs11908032	C>S	A:448	(-50.60, 42.08, 13.74)
20:3838400	rs11905552	C>F	A:448	(-50.60, 42.08, 13.74)
20:3838417		A>T	A:454	(-48.40, 33.96, 19.05)
20:3838418	COSM4098351	A>V	A:454	(-48.40, 33.96, 19.05)
20:3838421		D>G	A:455	(-50.13, 32.01, 21.95)
20:3838423	rs140113155	E>K	A:456	(-49.32, 28.28, 17.46)
20:3838425		E>D	A:456	(-49.32, 28.28, 17.46)
20:3838430		A>V	A:458	(-44.82, 30.15, 22.37)