Assessment of Structural Intolerance and Durability
General Structure Information 2o8b MSH2 human mutsalpha (msh2/msh6) bound to adp and a g t mispair 2.75Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wer RASA1 ras-gtpase-activating domain of human p120gap 1.6Å AUTH K.SCHEFFZEK,A.LAUTWEIN,W.KABSCH,M.R.AHMADIAN,AUTH 2 A.WITTINGHOFERTITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATING DOMAINTITL 2 OF HUMAN P120GAP AND IMPLICATIONS FOR THETITL 3 INTERACTION WITH RAS.REF NATURE V. 384 591 1996REFN ISSN 0028-0836PMID 8955277DOI 10.1038/384591A0 Variant Set Distributions Mapped Variants
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bbb NME2 crystal structure of the nm23-h2 transcription factor complex with dinucleotide d(ag) 1.3Å AUTH T.S.DEXHEIMER,S.S.CAREY,S.ZUOHE,V.M.GOKHALE,X.HU,L.B.MURATA,AUTH 2 E.M.MAES,A.WEICHSEL,D.SUN,E.J.MEUILLET,W.R.MONTFORT,AUTH 3 L.H.HURLEYTITL NM23-H2 MAY PLAY AN INDIRECT ROLE IN TRANSCRIPTIONALTITL 2 ACTIVATION OF C-MYC GENE EXPRESSION BUT DOES NOT CLEAVE THETITL 3 NUCLEASE HYPERSENSITIVE ELEMENT III1.REF MOL.CANCER THER. V. 8 1363 2009REFN ISSN 1535-7163PMID […]
General Structure Information 2ke5 RALB solution structure and dynamics of the small gtpase ralb in its active conformation: significance for effector protein binding -1.0Å AUTH R.B.FENWICK,S.PRASANNAN,L.J.CAMPBELL,D.NIETLISPACH,AUTH 2 K.A.EVETTS,J.CAMONIS,H.R.MOTT,D.OWENTITL SOLUTION STRUCTURE AND DYNAMICS OF THE SMALL GTPASETITL 2 RALB IN ITS ACTIVE CONFORMATION: SIGNIFICANCE FORTITL 3 EFFECTOR PROTEIN BINDINGREF BIOCHEMISTRY V. 48 2192 2009REFN ISSN 0006-2960PMID […]
General Structure Information 2y3i PGK1 the structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride 2.9Å AUTH P.LALLEMAND,L.CHALOIN,B.ROY,T.BARMAN,M.W.BOWLER,C.LIONNETITL INTERACTION OF HUMAN 3-PHOSPHOGLYCERATE KINASE WITH ITS TWOTITL 2 SUBSTRATES: IS SUBSTRATE ANTAGONISM A KINETIC ADVANTAGE?REF J.MOL.BIOL. V. 409 742 2011REFN ISSN 0022-2836PMID 21549713DOI 10.1016/J.JMB.2011.04.048 Variant Set […]
General Structure Information 1juj TYMS human thymidylate synthase bound to dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate 3.0Å AUTH P.H.SAYRE,J.S.FINER-MOORE,T.A.FRITZ,D.BIERMANN,AUTH 2 S.B.GATES,W.C.MACKELLAR,V.F.PATEL,R.M.STROUDTITL MULTI-TARGETED ANTIFOLATES AIMED AT AVOIDING DRUGTITL 2 RESISTANCE FORM COVALENT CLOSED INHIBITORYTITL 3 COMPLEXES WITH HUMAN AND ESCHERICHIA COLITITL 4 THYMIDYLATE SYNTHASES.REF J.MOL.BIOL. V. 313 813 2001REFN ISSN 0022-2836PMID 11697906DOI 10.1006/JMBI.2001.5074 Variant Set Distributions […]
General Structure Information 1wwy TXNL1 solution structure of the duf1000 domain of a thioredoxin-like protein 1 -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.INOUE,A.TANAKA,AUTH 2 S.SUGANO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL DUF1000 DOMAIN OF THETITL 2 HUMAN THIOREDOXIN-LIKE 1 PROTEIN.REF PROTEINS V. 78 2176 2010REFN ISSN 0887-3585PMID 20455272DOI 10.1002/PROT.22719 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]