Assessment of Structural Intolerance and Durability
General Structure Information 2ygq WIF1 wif domain-epidermal growth factor (egf)-like domains 1-3 of human wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine 3.95Å AUTH T.MALINAUSKAS,A.R.ARICESCU,W.LU,C.SIEBOLD,E.Y.JONESTITL MODULAR MECHANISM OF WNT SIGNALING INHIBITION BY WNTTITL 2 INHIBITORY FACTOR 1REF NAT.STRUCT.MOL.BIOL. V. 18 886 2011REFN ISSN 1545-9993PMID 21743455DOI 10.1038/NSMB.2081 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2iwi PIM2 crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1 2.8Å AUTH A.N.BULLOCK,S.RUSSO,A.AMOS,N.PAGANO,H.BREGMAN,AUTH 2 J.E.DEBRECZENI,W.H.LEE,F.VON DELFT,E.MEGGERS,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF THE PIM2 KINASE IN COMPLEXTITL 2 WITH AN ORGANORUTHENIUM INHIBITOR.REF PLOS ONE V. 4 E7112 2009REFN ISSN 1932-6203PMID 19841674DOI 10.1371/JOURNAL.PONE.0007112 Variant Set Distributions Ripley’s K […]
General Structure Information 3lq9 DDIT4 crystal strucure of human redd1, a hypoxia-induced regulator of mtor 2.0Å AUTH S.VEGA-RUBIN-DE-CELIS,Z.ABDALLAH,L.KINCH,AUTH 2 N.V.GRISHIN,J.BRUGAROLAS,X.ZHANGTITL STRUCTURAL ANALYSIS AND FUNCTIONAL IMPLICATIONS OFTITL 2 THE NEGATIVE MTORC1 REGULATOR REDD1.REF BIOCHEMISTRY V. 49 2491 2010REFN ISSN 0006-2960PMID 20166753DOI 10.1021/BI902135E Variant Set Distributions Mapped Variants
General Structure Information 2xus BRMS1 crystal structure of the brms1 n-terminal region 1.912Å AUTH M.SPINOLA-AMILIBIA,J.RIVERA,M.ORTIZ-LOMBARDIA,A.ROMERO,AUTH 2 J.L.NEIRA,J.BRAVOTITL THE STRUCTURE OF BRMS1 NUCLEAR EXPORT SIGNAL AND SNX6TITL 2 INTERACTING REGION REVEALS A HEXAMER FORMED BY ANTIPARALLELTITL 3 COILED COILS.REF J.MOL.BIOL. V. 411 1114 2011REFN ISSN 0022-2836PMID 21777593DOI 10.1016/J.JMB.2011.07.006 Variant Set Distributions Mapped Variants
General Structure Information 4fgu LGMN crystal structure of prolegumain 3.9Å AUTH E.DALL,H.BRANDSTETTERTITL MECHANISTIC AND STRUCTURAL STUDIES ON LEGUMAIN EXPLAIN ITSTITL 2 ZYMOGENICITY, DISTINCT ACTIVATION PATHWAYS, AND REGULATION.REF PROC.NATL.ACAD.SCI.USA V. 110 10940 2013REFN ISSN 0027-8424PMID 23776206DOI 10.1073/PNAS.1300686110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rkb SDSL serine dehydratase like-1 from human cancer cells 2.8Å AUTH T.YAMADA,J.KOMOTO,T.KASUYA,Y.TAKATA,H.OGAWA,H.MORI,AUTH 2 F.TAKUSAGAWATITL A CATALYTIC MECHANISM THAT EXPLAINS A LOW CATALYTIC ACTIVITYTITL 2 OF SERINE DEHYDRATASE LIKE-1 FROM HUMAN CANCER CELLS:TITL 3 CRYSTAL STRUCTURE AND SITE-DIRECTED MUTAGENESIS STUDIES.REF BIOCHIM.BIOPHYS.ACTA V.1780 809 2008REFN ISSN 0006-3002PMID 18342636DOI 10.1016/J.BBAGEN.2008.01.020 Variant Set Distributions Ripley’s K […]
General Structure Information 2x4f MYLK4 the crystal structure of the human myosin light chain kinase loc340156. 2.67Å AUTH J.R.C.MUNIZ,P.MAHAJAN,P.RELLOS,O.FEDOROV,B.SHRESTHA,J.WANG,AUTH 2 J.M.ELKINS,N.DAGA,R.COCKING,A.CHAIKUAD,T.KROJER,E.UGOCHUKWU,AUTH 3 W.YUE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 4 C.BOUNTRA,O.GILEADI,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAINTITL 2 KINASE LOC340156REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4aqi S100A7A structure of human s100a15 bound to zinc and calcium 1.7Å AUTH J.I.MURRAY,M.L.TONKIN,A.L.WHITING,F.PENG,B.FARNELL,AUTH 2 J.T.CULLEN,F.HOF,M.J.BOULANGERTITL STRUCTURAL CHARACTERIZATION OF S100A15 REVEALS A NOVEL ZINCTITL 2 COORDINATION SITE AMONG S100 PROTEINS AND ALTERED SURFACETITL 3 CHEMISTRY WITH FUNCTIONAL IMPLICATIONS FOR RECEPTORTITL 4 BINDING.REF BMC STRUCT.BIOL. V. 12 16 2012REFN ISSN 1472-6807PMID 22747601DOI 10.1186/1472-6807-12-16 […]
General Structure Information 4b87 DCLRE1A crystal structure of human dna cross-link repair 1a 2.16Å AUTH C.K.ALLERSTON,G.BERRIDGE,E.P.CARPENTER,G.KOCHAN,T.KROJER,AUTH 2 P.MAHAJAN,M.VOLLMAR,W.W.YUE,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b3z CRMP1 structure of the human collapsin response mediator protein-1, a lung cancer suppressor 3.05Å AUTH S.H.LIU,S.F.HUANG,Y.L.HSU,S.H.PAN,Y.J.CHEN,Y.H.LINTITL STRUCTURE OF HUMAN COLLAPSIN RESPONSE MEDIATOR PROTEIN 1: ATITL 2 POSSIBLE ROLE OF ITS C-TERMINAL TAIL.REF ACTA CRYSTALLOGR.,SECT.F V. 71 938 2015REFN ISSN 1744-3091PMID 26249678DOI 10.1107/S2053230X15009243 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]