Assessment of Structural Intolerance and Durability
General Structure Information 4cnc TPBG crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein) 1.77Å AUTH Y.ZHAO,T.MALINAUSKAS,K.HARLOS,E.Y.JONESTITL STRUCTURAL INSIGHTS INTO THE INHIBITION OF WNT SIGNALING BYTITL 2 CANCER ANTIGEN 5T4/WNT-ACTIVATED INHIBITORY FACTOR 1.REF STRUCTURE V. 22 612 2014REFN ISSN 0969-2126PMID 24582434DOI 10.1016/J.STR.2014.01.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2z7q RPS6KA1 crystal structure of the n-terminal kinase domain of human rsk-1 bound to amp-pcp 2.0Å AUTH M.IKUTA,M.KORNIENKO,N.BYRNE,J.C.REID,S.MIZUARAI,H.KOTANI,AUTH 2 S.K.MUNSHITITL CRYSTAL STRUCTURES OF THE N-TERMINAL KINASE DOMAIN OF HUMANTITL 2 RSK1 BOUND TO THREE DIFFERENT LIGANDS: IMPLICATIONS FOR THETITL 3 DESIGN OF RSK1 SPECIFIC INHIBITORS.REF PROTEIN SCI. V. 16 2626 2007REFN ISSN […]
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 1wch PTPN13 crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer – evidence for a second phosphotyrosine substrate recognition pocket 1.85Å AUTH F.VILLA,M.DEAK,G.B.BLOOMBERG,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF PTPL1/FAP-1 HUMAN TYROSINETITL 2 PHOSPHATASE MUTATED IN COLORECTAL CANCER:TITL 3 EVEIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATETITL 4 RECOGNITION POCKETREF J.BIOL.CHEM. V. […]
General Structure Information 1n0w RAD51 crystal structure of a rad51-brca2 brc repeat complex 1.7Å AUTH L.PELLEGRINI,D.S.YU,T.LO,S.ANAND,M.LEE,AUTH 2 T.L.BLUNDELL,A.R.VENKITARAMANTITL INSIGHTS INTO DNA RECOMBINATION FROM THE STRUCTURETITL 2 OF A RAD51-BRCA2 COMPLEXREF NATURE V. 420 287 2002REFN ISSN 0028-0836PMID 12442171DOI 10.1038/NATURE01230 Variant Set Distributions Mapped Variants
General Structure Information 3o34 HIST1H3H crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide 1.9Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Mapped Variants
General Structure Information 3o34 HIST1H3J crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide 1.9Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Mapped Variants
General Structure Information 3o34 HIST1H3D crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide 1.9Å AUTH W.W.TSAI,Z.WANG,T.T.YIU,K.C.AKDEMIR,W.XIA,S.WINTER,C.Y.TSAI,AUTH 2 X.SHI,D.SCHWARZER,W.PLUNKETT,B.ARONOW,O.GOZANI,W.FISCHLE,AUTH 3 M.C.HUNG,D.J.PATEL,M.C.BARTONTITL TRIM24 LINKS A NON-CANONICAL HISTONE SIGNATURE TO BREASTTITL 2 CANCER.REF NATURE V. 468 927 2010REFN ISSN 0028-0836PMID 21164480DOI 10.1038/NATURE09542 Variant Set Distributions Mapped Variants