General Structure Information
| PDB ID | 1juj |
| HGNC Gene Label(s) | TYMS |
| Structure Name | human thymidylate synthase bound to dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate |
| Resolution | 3.0Å |
| Reference | AUTH P.H.SAYRE,J.S.FINER-MOORE,T.A.FRITZ,D.BIERMANN,AUTH 2 S.B.GATES,W.C.MACKELLAR,V.F.PATEL,R.M.STROUDTITL MULTI-TARGETED ANTIFOLATES AIMED AT AVOIDING DRUGTITL 2 RESISTANCE FORM COVALENT CLOSED INHIBITORYTITL 3 COMPLEXES WITH HUMAN AND ESCHERICHIA COLITITL 4 THYMIDYLATE SYNTHASES.REF J.MOL.BIOL. V. 313 813 2001REFN ISSN 0022-2836PMID 11697906DOI 10.1006/JMBI.2001.5074 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 286 |
| Number Of SNVs | 40 |
| Number Of Permutations | 11453 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.022 |
| p-value | 0.83 |
COSMIC
| Number Of Residues | 286 |
| Number Of SNVs | 6 |
| Number Of Permutations | 254 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.067 |
| p-value | 0.334 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.523 |
| p-value | 0.043 |