Assessment of Structural Intolerance and Durability
General Structure Information 4lnz MYO5B crystal structure of human myosin 5b globular domain 3.11Å AUTH H.VELVARSKA,D.NIESSINGTITL STRUCTURAL INSIGHTS INTO THE GLOBULAR TAILS OF THE HUMANTITL 2 TYPE V MYOSINS MYO5A, MYO5B, AND MYO5C.REF PLOS ONE V. 8 82065 2013REFN ESSN 1932-6203PMID 24339992DOI 10.1371/JOURNAL.PONE.0082065 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3lyr EBF1 human early b-cell factor 1 (ebf1) dna-binding domain 2.51Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]
General Structure Information 2dzj TECR 2dzj/solution structure of the n-terminal ubiquitin-like domain in human synaptic glycoprotein sc2 -1.0Å AUTH C.ZHAO,M.YONEYAMA,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL 2DZJ/SOLUTION STRUCTURE OF THE N-TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN IN HUMAN SYNAPTICTITL 3 GLYCOPROTEIN SC2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3qc8 FAF1 crystal structure of faf1 ubx domain in complex with p97/vcp n domain reveals the conserved fcisp touch-turn motif of ubx domain suffering conformational change 2.2Å AUTH K.H.KIM,W.KANG,S.W.SUH,J.K.YANGTITL CRYSTAL STRUCTURE OF FAF1 UBX DOMAIN IN COMPLEX WITH P97/VCPTITL 2 N DOMAIN REVEALS A CONFORMATIONAL CHANGE IN THE CONSERVEDTITL 3 FCISP TOUCH-TURN […]
General Structure Information 4lg8 PRPF19 crystal structure of prpf19 wd40 repeats 1.89Å AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3phd HDAC6 crystal structure of human hdac6 in complex with ubiquitin 3.0Å AUTH H.OUYANG,Y.O.ALI,M.RAVICHANDRAN,A.DONG,W.QIU,F.MACKENZIE,AUTH 2 S.DHE-PAGANON,C.H.ARROWSMITH,R.G.ZHAITITL PROTEIN AGGREGATES ARE RECRUITED TO AGGRESOME BY HISTONETITL 2 DEACETYLASE 6 VIA UNANCHORED UBIQUITIN C TERMINI.REF J.BIOL.CHEM. V. 287 2317 2012REFN ISSN 0021-9258PMID 22069321DOI 10.1074/JBC.M111.273730 Variant Set Distributions Mapped Variants
General Structure Information 4cq1 PTBP2 crystal structure of the neuronal isoform of ptb 1.69Å AUTH A.JOSHI,V.ESTEVE,A.N.BUCKROYD,M.BLATTER,F.H.-T.ALLAIN,AUTH 2 S.CURRYTITL SOLUTION AND CRYSTAL STRUCTURES OF A C TERMINAL FRAGMENT OFTITL 2 THE NEURONAL ISOFORM OF THE POLYPYRIMIDINE TRACT BINDINGTITL 3 PROTEIN (NPTB)REF PEERJ V. 2 E211 2014REFN ISSN 2167-8359DOI 10.7287/PEERJ.PREPRINTS.211V1 Variant Set Distributions Mapped Variants
General Structure Information 2l0f POLI solution nmr structure of human polymerase iota ubm2 (p692a mutant) in complex with ubiquitin -1.0Å AUTH G.CUI,R.C.BENIRSCHKE,H.F.TUAN,N.JURANIC,S.MACURA,AUTH 2 M.V.BOTUYAN,G.MERTITL STRUCTURAL BASIS OF UBIQUITIN RECOGNITION BY TRANSLESIONTITL 2 SYNTHESIS DNA POLYMERASE IOTA.REF BIOCHEMISTRY V. 49 10198 2010REFN ISSN 0006-2960PMID 21049971DOI 10.1021/BI101303T Variant Set Distributions Mapped Variants