Assessment of Structural Intolerance and Durability
General Structure Information 1wjp ZBTB21 solution structure of zf-c2h2 domains from human zinc finger protein 295 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF ZF-C2H2 DOMAINS FROM HUMANTITL 2 ZINC FINGER PROTEIN 295REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wi1 CADPS solution structure of the ph domain of human calcium- dependent activator protein for secretion (caps) -1.0Å AUTH M.YONEYAMA,K.IZUMI,M.YOSHIDA,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF HUMANTITL 2 CALCIUM-DEPENDENT ACTIVATOR PROTEIN FOR SECRETIONTITL 3 (CAPS)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f9b DBF4 human cdc7 kinase in complex with dbf4 and pha767491 2.5Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Mapped Variants
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ln3 PCTP structure of human phosphatidylcholine transfer protein in complex with palmitoyl-linoleoyl phosphatidylcholine (seleno-met protein) 2.9Å AUTH S.L.RODERICK,W.W.CHAN,D.S.AGATE,L.R.OLSEN,AUTH 2 M.W.VETTING,K.R.RAJASHANKAR,D.E.COHENTITL STRUCTURE OF HUMAN PHOSPHATIDYLCHOLINE TRANSFERTITL 2 PROTEIN IN COMPLEX WITH ITS LIGAND.REF NAT.STRUCT.BIOL. V. 9 507 2002REFN ISSN 1072-8368PMID 12055623 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1×51 MUTYH solution structure of the nudix domain from human a/g- specific adenine dna glycosylase alpha-3 splice isoform -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NUDIX DOMAIN FROM HUMANTITL 2 A/G-SPECIFIC ADENINE DNA GLYCOSYLASE ALPHA-3TITL 3 SPLICE ISOFORMREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rr3 VAPA solution structure of the complex between human vap-a msp domain and human osbp ffat motif -1.0Å AUTH K.FURUITA,J.JEE,H.FUKADA,M.MISHIMA,C.KOJIMATITL ELECTROSTATIC INTERACTION BETWEEN OXYSTEROL-BINDING PROTEINTITL 2 AND VAMP-ASSOCIATED PROTEIN A REVEALED BY NMR ANDTITL 3 MUTAGENESIS STUDIESREF J.BIOL.CHEM. V. 285 12961 2010REFN ISSN 0021-9258PMID 20178991DOI 10.1074/JBC.M109.082602 Variant Set Distributions Mapped Variants
General Structure Information 2k40 HESX1 nmr structure of hesx-1 homeodomain double mutant r31l/e42l -1.0Å AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qwe GMIP crystal structure of the n-terminal domain of the gem interacting protein 2.4Å AUTH X.GUAN,W.TEMPEL,Y.TONG,L.SHEN,H.WANG,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE GEMTITL 2 INTERACTING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1d9n MBD1 solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional repressor mbd1/pcm1 -1.0Å AUTH I.OHKI,N.SHIMOTAKE,N.FUJITA,M.NAKAO,M.SHIRAKAWATITL SOLUTION STRUCTURE OF THE METHYL-CPG-BINDINGTITL 2 DOMAIN OF THE METHYLATION-DEPENDENTTITL 3 TRANSCRIPTIONAL REPRESSOR MBD1.REF EMBO J. V. 18 6653 1999REFN ISSN 0261-4189PMID 10581239DOI 10.1093/EMBOJ/18.23.6653 Variant Set Distributions Mapped Variants