Assessment of Structural Intolerance and Durability
General Structure Information 1wim RNF144A solution structure of the ring finger domain of the human ubcm4-interacting protein 4 -1.0Å AUTH K.MIYAMOTO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING FINGER DOMAIN OFTITL 2 THE HUMAN UBCM4-INTERACTING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ls6 SULT1A1 human sult1a1 complexed with pap and p-nitrophenol 1.9Å AUTH N.U.GAMAGE,R.G.DUGGLEBY,A.C.BARNETT,M.TRESILLIAN,AUTH 2 C.F.LATHAM,N.E.LIYOU,M.E.MCMANUS,J.L.MARTINTITL STRUCTURE OF A HUMAN CARCINOGEN-CONVERTING ENZYME,TITL 2 SULT1A1. STRUCTURAL AND KINETIC IMPLICATIONS OFTITL 3 SUBSTRATE INHIBITION.REF J.BIOL.CHEM. V. 278 7655 2003REFN ISSN 0021-9258PMID 12471039DOI 10.1074/JBC.M207246200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rr8 IQGAP1 solution structure of calponin homology domain of iqgap1 -1.0Å AUTH R.UMEMOTO,N.NISHIDA,S.OGINO,I.SHIMADATITL NMR STRUCTURE OF THE CALPONIN HOMOLOGY DOMAIN OF HUMANTITL 2 IQGAP1 AND ITS IMPLICATIONS FOR THE ACTIN RECOGNITION MODE.REF J.BIOMOL.NMR V. 48 59 2010REFN ISSN 0925-2738PMID 20644981DOI 10.1007/S10858-010-9434-8 Variant Set Distributions Mapped Variants
General Structure Information 4go6 HCFC1 crystal structure of hcf-1 self-association sequence 1 2.7Å AUTH J.PARK,F.LAMMERS,W.HERR,J.SONGTITL HCF-1 SELF-ASSOCIATION VIA AN INTERDIGITATED FN3 STRUCTURETITL 2 FACILITATES TRANSCRIPTIONAL REGULATORY COMPLEX FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 109 17430 2012REFN ISSN 0027-8424PMID 23045687DOI 10.1073/PNAS.1208378109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dem MASP1 cub1-egf-cub2 domain of human masp-1/3 2.3Å AUTH F.TEILLET,C.GABORIAUD,M.LACROIX,L.MARTIN,G.J.ARLAUD,AUTH 2 N.M.THIELENSTITL CRYSTAL STRUCTURE OF THE CUB1-EGF-CUB2 DOMAIN OF HUMANTITL 2 MASP-1/3 AND IDENTIFICATION OF ITS INTERACTION SITES WITHTITL 3 MANNAN-BINDING LECTIN AND FICOLINSREF J.BIOL.CHEM. V. 283 25715 2008REFN ISSN 0021-9258PMID 18596036DOI 10.1074/JBC.M803551200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2ekx BMX solution structure of the human bmx sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN BMX SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gfu MSH6 nmr solution structure of the pwwp domain of mismatch repair protein hmsh6 -1.0Å AUTH C.LAGURI,I.DUBAND-GOULET,N.FRIEDRICH,M.AXT,P.BELIN,AUTH 2 B.GILQUIN,S.ZINN-JUSTIN,J.COUPRIETITL THE PWWP DOMAIN OF MISMATCH REPAIR PROTEIN HMSH6TITL 2 IS INVOLVED IN DOUBLE STRANDED AND SINGLE STRANDEDTITL 3 DNA BINDINGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2o8d MSH6 human mutsalpha (msh2/msh6) bound to adp and a g du mispair 3.0Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bcj CDK9 structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor 3.16Å AUTH A.J.HOLE,S.BAUMLI,H.SHAO,S.SHI,C.PEPPER,P.M.FISCHER,S.WANG,AUTH 2 J.A.ENDICOTT,M.E.M.NOBLETITL COMPARATIVE STRUCTURAL AND FUNCTIONAL STUDIES OFTITL 2 4-(THIAZOL- 5-YL)-2-(PHENYLAMINO)PYRIMIDINE-5-CARBONITRILETITL 3 CDK9 INHIBITORS SUGGEST THE BASIS FOR ISOTYPE SELECTIVITY.REF J.MED.CHEM. V. 56 660 2013REFN ISSN 0022-2623PMID 23252711DOI 10.1021/JM301495V Variant Set Distributions Mapped Variants
General Structure Information 3an2 CENPA the structure of the centromeric nucleosome containing cenp-a 3.6Å AUTH H.TACHIWANA,W.KAGAWA,T.SHIGA,A.OSAKABE,Y.MIYA,K.SAITO,AUTH 2 Y.HAYASHI-TAKANAKA,T.ODA,M.SATO,S.-Y.PARK,H.KIMURA,AUTH 3 H.KURUMIZAKATITL CRYSTAL STRUCTURE OF THE HUMAN CENTROMERIC NUCLEOSOMETITL 2 CONTAINING CENP-AREF NATURE V. 476 232 2011REFN ISSN 0028-0836PMID 21743476DOI 10.1038/NATURE10258 Variant Set Distributions Mapped Variants