Assessment of Structural Intolerance and Durability
General Structure Information 1rgo ZFP36L2 structural basis for recognition of the mrna class ii au- rich element by the tandem zinc finger domain of tis11d -1.0Å AUTH B.P.HUDSON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,P.E.WRIGHTTITL RECOGNITION OF THE MRNA AU-RICH ELEMENT BY THETITL 2 ZINC FINGER DOMAIN OF TIS11D.REF NAT.STRUCT.MOL.BIOL. V. 11 257 2004REFN ISSN 1545-9993PMID 14981510DOI 10.1038/NSMB738 Variant Set Distributions Ripley’s […]
General Structure Information 1wyp CNN1 solution structure of the ch domain of human calponin 1 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMANTITL 2 CALPONIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4cff PRKAA2 structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) 3.92Å AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1g25 MNAT1 solution structure of the n-terminal domain of the human tfiih mat1 subunit -1.0Å AUTH V.GERVAIS,D.BUSSO,E.WASIELEWSKI,A.POTERSZMAN,AUTH 2 J.M.EGLY,J.C.THIERRY,B.KIEFFERTITL SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THETITL 2 HUMAN TFIIH MAT1 SUBUNIT: NEW INSIGHTS INTO THETITL 3 RING FINGER FAMILYREF J.BIOL.CHEM. V. 276 7457 2001REFN ISSN 0021-9258PMID 11056162DOI 10.1074/JBC.M007963200 Variant Set Distributions […]
General Structure Information 4ivo PPOX structure of human protoporphyrinogen ix oxidase(r59q) 2.6Å AUTH B.WANG,X.WEN,X.QIN,Z.WANG,Y.TAN,Y.SHEN,Z.XITITL QUANTITATIVE STRUCTURAL INSIGHT INTO HUMAN VARIEGATETITL 2 PORPHYRIA DISEASE.REF J.BIOL.CHEM. V. 288 11731 2013REFN ISSN 0021-9258PMID 23467411DOI 10.1074/JBC.M113.459768 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1o1v FABP6 human ileal lipid-binding protein (ilbp) in complex with cholyltaurine -1.0Å AUTH M.KURZ,V.BRACHVOGEL,H.MATTER,S.STENGELIN,AUTH 2 H.THUERING,W.KRAMERTITL INSIGHTS INTO THE BILE ACID TRANSPORTATION SYSTEM:TITL 2 THE HUMAN ILEAL LIPID-BINDINGTITL 3 PROTEIN-CHOLYLTAURINE COMPLEX AND ITS COMPARISONTITL 4 WITH HOMOLOGOUS STRUCTURES.REF PROTEINS V. 50 312 2003REFN ISSN 0887-3585PMID 12486725DOI 10.1002/PROT.10289 Variant Set Distributions Ripley’s K […]
General Structure Information 2o10 CSRP3 solution structure of the n-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o13 CSRP3 solution structure of the c-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kw3 RFX5 heterotrimeric interaction between rfx5 and rfxap -1.0Å AUTH K.M.LAIRD,L.L.BRIGGS,J.M.BOSS,M.F.SUMMERS,C.W.GARVIETITL SOLUTION STRUCTURE OF THE HETEROTRIMERIC COMPLEX BETWEENTITL 2 RFX5 AND RFXAP REVEALS MOLECULAR DETAILS ASSOCIATED WITHTITL 3 MHCII GENE EXPRESSIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x6h CTCF solution structures of the c2h2 type zinc finger domain of human transcriptional repressor ctcf -1.0Å AUTH M.SATO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN TRANSCRIPTIONAL REPRESSOR CTCFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants