Assessment of Structural Intolerance and Durability
General Structure Information 3d2n MBNL1 crystal structure of mbnl1 tandem zinc finger 1 and 2 domain 2.7Å AUTH M.TEPLOVA,D.J.PATELTITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY THETITL 2 ALTERNATIVE-SPLICING REGULATOR MUSCLEBLIND-LIKETITL 3 MBNL1.REF NAT.STRUCT.MOL.BIOL. V. 15 1343 2008REFN ISSN 1545-9993PMID 19043415DOI 10.1038/NSMB.1519 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1wel RBM12 solution structure of rna binding domain in np_006038 -1.0Å AUTH T.SOMEYA,Y.MUTO,T.NAGATA,S.SUZUKI,M.INOUE,T.KIGAWA,AUTH 2 T.TERADA,M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 NP_006038REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xml KDM4C crystal structure of human jmjd2c catalytic domain 2.55Å AUTH L.HILLRINGHAUS,W.W.YUE,N.R.ROSE,S.S.NG,C.GILEADI,C.LOENARZ,AUTH 2 S.H.BELLO,J.E.BRAY,C.J.SCHOFIELD,U.OPPERMANNTITL STRUCTURAL AND EVOLUTIONARY BASIS FOR THE DUAL SUBSTRATETITL 2 SELECTIVITY OF HUMAN KDM4 HISTONE DEMETHYLASE FAMILY.REF J.BIOL.CHEM. V. 286 41616 2011REFN ISSN 0021-9258PMID 21914792DOI 10.1074/JBC.M111.283689 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3k6g TERF2IP crystal structure of rap1 and trf2 complex 1.95Å AUTH Y.CHEN,R.RAI,Z.R.ZHOU,J.KANOH,C.RIBEYRE,Y.YANG,H.ZHENG,AUTH 2 P.DAMAY,F.WANG,H.TSUJII,Y.HIRAOKA,D.SHORE,H.Y.HU,S.CHANG,AUTH 3 M.LEITITL A CONSERVED MOTIF WITHIN RAP1 HAS DIVERSIFIED ROLES INTITL 2 TELOMERE PROTECTION AND REGULATION IN DIFFERENT ORGANISMS.REF NAT.STRUCT.MOL.BIOL. V. 18 213 2011REFN ISSN 1545-9993PMID 21217703DOI 10.1038/NSMB.1974 Variant Set Distributions Mapped Variants
General Structure Information 3rwr NHEJ1 crystal structure of the human xrcc4-xlf complex 3.94Å AUTH N.S.ANDRES,C.WYMAN,M.MODESTI,M.S.JUNOPTITL STRUCTURE OF HUMAN XLF-XRCC4: ASSEMBLY OF A FUNCTIONAL DNATITL 2 REPAIR COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hve GAN structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: gigaxoninbtb/3-box 2.8Å AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3hy8 PNPO crystal structure of human pyridoxine 5-phosphate oxidase r229w mutant 2.5Å AUTH F.N.MUSAYEV,M.L.DI SALVO,M.A.SAAVEDRA,R.CONTESTABILE,AUTH 2 M.S.GHATGE,A.HAYNES,V.SCHIRCH,M.K.SAFOTITL MOLECULAR BASIS OF REDUCED PYRIDOXINE 5-PHOSPHATE OXIDASETITL 2 CATALYTIC ACTIVITY IN NEONATAL EPILEPTIC ENCEPHALOPATHYTITL 3 DISORDERREF J.BIOL.CHEM. V. 284 30949 2009REFN ISSN 0021-9258PMID 19759001DOI 10.1074/JBC.M109.038372 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kxq SMURF2 solution structure of smurf2 ww2 and ww3 bound to smad7 py motif containing peptide -1.0Å AUTH P.A.CHONG,H.LIN,J.L.WRANA,J.D.FORMAN-KAYTITL COUPLING OF TANDEM SMAD UBIQUITINATION REGULATORY FACTORTITL 2 (SMURF) WW DOMAINS MODULATES TARGET SPECIFICITY.REF PROC.NATL.ACAD.SCI.USA V. 107 18404 2010REFN ISSN 0027-8424PMID 20937913DOI 10.1073/PNAS.1003023107 Variant Set Distributions Mapped Variants
General Structure Information 1sl6 CLEC4M crystal structure of a fragment of dc-signr (containg the carbohydrate recognition domain and two repeats of the neck) complexed with lewis-x. 2.25Å AUTH Y.GUO,H.FEINBERG,E.CONROY,D.A.MITCHELL,R.ALVAREZ,AUTH 2 O.BLIXT,M.E.TAYLOR,W.I.WEIS,K.DRICKAMERTITL STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING ANDTITL 2 TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN ANDTITL 3 DC-SIGNRREF NAT.STRUCT.MOL.BIOL. V. 11 591 2004REFN ISSN 1545-9993PMID 15195147DOI […]
General Structure Information 2cpy RBM12 solution structure of rna binding domain 3 in rna binding motif protein 12 -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN 3 IN RNATITL 2 BINDING MOTIF PROTEIN 12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants