Assessment of Structural Intolerance and Durability
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4joi OBFC1 crystal structure of the human telomeric stn1-ten1 complex 2.05Å AUTH C.BRYAN,C.RICE,M.HARKISHEIMER,D.C.SCHULTZ,E.SKORDALAKESTITL STRUCTURE OF THE HUMAN TELOMERIC STN1-TEN1 CAPPING COMPLEX.REF PLOS ONE V. 8 66756 2013REFN ESSN 1932-6203PMID 23826127DOI 10.1371/JOURNAL.PONE.0066756 Variant Set Distributions Mapped Variants
General Structure Information 2xc7 PHAX solution structure of phax-rbd in complex with ssrna -1.0Å AUTH A.MOURAO,A.VARROT,C.D.MACKERETH,S.CUSACK,M.SATTLERTITL STRUCTURE AND RNA RECOGNITION BY THE SNRNA ANDTITL 2 SNORNA TRANSPORT FACTOR PHAX.REF RNA V. 16 1205 2010REFN ISSN 1355-8382PMID 20430857DOI 10.1261/RNA.2009910 Variant Set Distributions Mapped Variants
General Structure Information 2iqc FANCF crystal structure of human fancf protein that functions in the assembly of a dna damage signaling complex 2.4Å AUTH P.KOWAL,A.M.GURTAN,P.STUCKERT,A.D.DANDREA,AUTH 2 T.ELLENBERGERTITL STRUCTURAL DETERMINANTS OF HUMAN FANCF PROTEINTITL 2 THAT FUNCTION IN THE ASSEMBLY OF A DNA DAMAGETITL 3 SIGNALING COMPLEX.REF J.BIOL.CHEM. V. 282 2047 2007REFN ISSN 0021-9258PMID 17082180DOI 10.1074/JBC.M608356200 […]
General Structure Information 2wm3 NMRAL1 crystal structure of nmra-like family domain containing protein 1 in complex with niflumic acid 1.85Å AUTH C.BHATIA,W.W.YUE,E.PILKA,E.UGOCHUKWU,P.SAVITSKY,V.HOZJAN,AUTH 2 A.K.ROOS,P.FILIPPAKOPOULOS,F.VON DELFT,T.HEIGHTMAN,AUTH 3 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAININGTITL 2 PROTEIN 1 IN COMPLEX WITH NIFLUMIC ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fm8 KIF13B crystal structure of full length centaurin alpha-1 bound with the fha domain of kif13b (capri target) 2.3Å AUTH Y.TONG,W.TEMPEL,H.WANG,K.YAMADA,L.SHEN,G.A.SENISTERRA,AUTH 2 F.MACKENZIE,A.H.CHISHTI,H.W.PARKTITL PHOSPHORYLATION-INDEPENDENT DUAL-SITE BINDING OF THE FHATITL 2 DOMAIN OF KIF13 MEDIATES PHOSPHOINOSITIDE TRANSPORT VIATITL 3 CENTAURIN ALPHA1.REF PROC.NATL.ACAD.SCI.USA V. 107 20346 2010REFN ISSN 0027-8424PMID 21057110DOI 10.1073/PNAS.1009008107 Variant Set Distributions […]
General Structure Information 4gdk ATG5 crystal structure of human atg12~atg5 conjugate in complex with an n- terminal fragment of atg16l1 2.7Å AUTH C.OTOMO,Z.METLAGEL,G.TAKAESU,T.OTOMOTITL STRUCTURE OF THE HUMAN ATG12~ATG5 CONJUGATE REQUIRED FOR LC3TITL 2 LIPIDATION IN AUTOPHAGY.REF NAT.STRUCT.MOL.BIOL. V. 20 59 2013REFN ISSN 1545-9993PMID 23202584DOI 10.1038/NSMB.2431 Variant Set Distributions Mapped Variants
General Structure Information 2kiu FOXP1 solution structure and backbone dynamics of the dna-binding domain of foxp1: insight into its domain swapping -1.0Å AUTH Y.P.CHU,C.H.CHANG,J.H.SHIU,Y.T.CHANG,C.Y.CHEN,W.J.CHUANGTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THE DNA-BINDINGTITL 2 DOMAIN OF FOXP1: INSIGHT INTO ITS DOMAIN SWAPPING AND DNATITL 3 BINDING.REF PROTEIN SCI. V. 20 908 2011REFN ISSN 0961-8368PMID 21416545DOI 10.1002/PRO.626 […]
General Structure Information 2eeh PDZD7 solution structure of first pdz domain of pdz domain containing protein 7 -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,T.TOMIZAWA,K.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF FIRST PDZ DOMAIN OF PDZTITL 2 DOMAIN CONTAINING PROTEIN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yra SEZ6L solution structure of the zinc finger domains (1-87) from human f-box only protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER DOMAINSTITL 2 (1-87) FROM HUMAN F-BOX ONLY PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants