General Structure Information 2w5a NEK2 human nek2 kinase adp-bound 1.55Å AUTH I.WESTWOOD,D.M.CHEARY,J.E.BAXTER,M.W.RICHARDS,AUTH 2 R.L.VAN MONTFORT,A.M.FRY,R.BAYLISSTITL INSIGHTS INTO THE CONFORMATIONAL VARIABILITY ANDTITL 2 REGULATION OF HUMAN NEK2 KINASE.REF J.MOL.BIOL. V. 386 476 2009REFN ISSN 0022-2836PMID 19124027DOI 10.1016/J.JMB.2008.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vxo GMPS human gmp synthetase in complex with xmp 2.5Å AUTH M.WELIN,L.LEHTIO,A.JOHANSSON,S.FLODIN,T.NYMAN,AUTH 2 L.TRESAUGUES,M.HAMMARSTROM,S.GRASLUND,P.NORDLUNDTITL SUBSTRATE SPECIFICITY AND OLIGOMERIZATION OF HUMANTITL 2 GMP SYNTHETASEREF J.MOL.BIOL. V. 425 4323 2013REFN ISSN 0022-2836PMID 23816837DOI 10.1016/J.JMB.2013.06.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r2p EPHA5 kinase domain of human ephrin type-a receptor 5 (epha5) 2.4Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gub DAPK1 crystal structure of dapkl93g complexed with n6-(2- phenylethyl)adenosine 1.71Å AUTH L.K.MCNAMARA,J.S.SCHAVOCKY,D.M.WATTERSON,AUTH 2 J.S.BRUNZELLETITL CRYSTAL STRUCTURES OF THE DAPK GATEKEEPER MUTANTTITL 2 COMPLEXED WITH N6-MODIFIED ADENOSINE ANALOGS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3enm MAP2K6 the structure of the map2k mek6 reveals an autoinhibitory dimer 2.35Å AUTH X.MIN,R.AKELLA,H.HE,J.M.HUMPHREYS,S.E.TSUTAKAWA,S.J.LEE,AUTH 2 J.A.TAINER,M.H.COBB,E.J.GOLDSMITHTITL THE STRUCTURE OF THE MAP2K MEK6 REVEALS AN AUTOINHIBITORYTITL 2 DIMERREF STRUCTURE V. 17 96 2009REFN ISSN 0969-2126PMID 19141286DOI 10.1016/J.STR.2008.11.007 Variant Set Distributions Mapped Variants
General Structure Information 3ii6 LIG4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Ripley’s K […]
General Structure Information 2kk1 ABL2 solution structure of c-terminal domain of tyrosine-protein kinase abl2 from homo sapiens, northeast structural genomics consortium (nesg) target hr5537a -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,AUTH 2 G.T.MONTELIONETITL NMR STRUCTURE OF F-ACTIN-BINDING DOMAIN OF ARG/ABL2TITL 2 FROM HOMO SAPIENS.REF PROTEINS V. 78 1326 2010REFN ISSN 0887-3585PMID 20077570DOI 10.1002/PROT.22656 Variant Set Distributions Mapped Variants
General Structure Information 2zt7 GARS crystal structure of human glycyl-trna synthetase (glyrs) in complex with glycine and atp 2.7Å AUTH R.T.GUO,Y.E.CHONG,M.GUO,X.L.YANGTITL CRYSTAL STRUCTURES AND BIOCHEMICAL ANALYSES SUGGESTTITL 2 UNIQUE MECHANISM AND ROLE FOR HUMAN GLYRS IN AP4ATITL 3 HOMEOSTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jdr AKT2 structure of pkb-beta (akt2) complexed with the inhibitor a- 443654 2.3Å AUTH T.G.DAVIES,M.L.VERDONK,B.GRAHAM,S.SAALAU-BETHELL,AUTH 2 C.C.F.HAMLETT,T.MCHARDY,I.COLLINS,M.D.GARRETT,AUTH 3 P.WORKMAN,S.J.WOODHEAD,H.JHOTI,D.BARFORDTITL A STRUCTURAL COMPARISON OF INHIBITOR BINDING TOTITL 2 PKB, PKA AND PKA-PKB CHIMERAREF J.MOL.BIOL. V. 367 882 2007REFN ISSN 0022-2836PMID 17275837DOI 10.1016/J.JMB.2007.01.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2k6g RFC1 solution structure of the dna binding brct domain from the large subunit of human replication factor c -1.0Å AUTH M.KOBAYASHI,E.AB,A.M.J.J.BONVIN,G.SIEGALTITL SOLUTION STRUCTURE OF THE DNA BOUND BRCT DOMAINTITL 2 FROM HUMAN REPLICATION FACTOR C P140REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants