Assessment of Structural Intolerance and Durability
General Structure Information 2x7g SRPK2 structure of human serine-arginine-rich protein-specific kinase 2 (srpk2) bound to purvalanol b 2.5Å AUTH A.C.W.PIKE,P.SAVITSKY,O.FEDOROV,T.KROJER,E.UGOCHUKWU,AUTH 2 F.VON DELFT,O.GILEADI,A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN- SPECIFICTITL 2 KINASE 2 (SRPK2) BOUND TO PURVALANOL BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ex7 MAGOH the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qkq EPHB4 structure of the sam domain of human ephrin type-b receptor 4 2.1Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-B RECEPTOR 4TITL 2 (EPHB4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3p1i EPHB3 ligand binding domain of human ephrin type-b receptor 3 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.KANIA,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL LIGAND BINDING DOMAIN OF HUMAN EPHB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fd5 SEPHS1 crystal structure of human selenophosphate synthetase 1 complex with ampcp 1.9Å AUTH K.T.WANG,J.WANG,L.F.LI,X.D.SUTITL CRYSTAL STRUCTURES OF CATALYTIC INTERMEDIATES OFTITL 2 HUMAN SELENOPHOSPHATE SYNTHETASE 1.REF J.MOL.BIOL. V. 390 747 2009REFN ISSN 0022-2836PMID 19477186DOI 10.1016/J.JMB.2009.05.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]
General Structure Information 3l2p LIG3 human dna ligase iii recognizes dna ends by dynamic switching between two dna bound states 3.0Å AUTH E.COTNER-GOHARA,I.K.KIM,M.HAMMEL,J.A.TAINER,A.E.TOMKINSON,AUTH 2 T.ELLENBERGERTITL HUMAN DNA LIGASE III RECOGNIZES DNA ENDS BY DYNAMICTITL 2 SWITCHING BETWEEN TWO DNA-BOUND STATES.REF BIOCHEMISTRY V. 49 6165 2010REFN ISSN 0006-2960PMID 20518483DOI 10.1021/BI100503W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2x2r KIF11 crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid 2.2Å AUTH H.Y.K.KAAN,J.WEISS,D.MENGER,V.ULAGANATHAN,K.TKOCZ,C.LAGGNER,AUTH 2 F.POPOWYCZ,B.JOSEPH,F.KOZIELSKITITL STRUCTURE-ACTIVITY RELATIONSHIP AND MULTIDRUG RESISTANCETITL 2 STUDY OF NEW S-TRITYL-L-CYSTEINE DERIVATIVES AS INHIBITORSTITL 3 OF EG5.REF J.MED.CHEM. V. 54 1576 2011REFN ISSN 0022-2623PMID 21344920DOI 10.1021/JM100991M Variant Set Distributions Mapped Variants
General Structure Information 4et7 EPHA5 crystal structure of eph receptor 5 2.6Å AUTH J.H.SHI,W.L.ZHU,J.X.SONGTITL CRYSTAL STRUCTURE OF EPH RECEPTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants