Assessment of Structural Intolerance and Durability
General Structure Information 3llm DHX9 crystal structure analysis of a rna helicase 2.8Å AUTH P.SCHUTZ,E.WAHLBERG,T.KARLBERG,M.HAMMARSTROM,R.COLLINS,AUTH 2 A.FLORES,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN RNA HELICASE A (DHX9): STRUCTURALTITL 2 BASIS FOR UNSELECTIVE NUCLEOTIDE BASE BINDING IN A DEAD-BOXTITL 3 VARIANT PROTEIN.REF J.MOL.BIOL. V. 400 768 2010REFN ISSN 0022-2836PMID 20510246DOI 10.1016/J.JMB.2010.05.046 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 2vd5 DMPK structure of human myotonic dystrophy protein kinase in complex with the bisindoylmaleide inhibitor bim viii 2.8Å AUTH J.ELKINS,A.AMOS,F.NIESEN,A.C.W.PIKE,O.FEDOROV,S.KNAPPTITL STRUCTURE OF DYSTROPHIA MYOTONICA PROTEIN KINASE.REF PROTEIN SCI. V. 18 782 2009REFN ISSN 0961-8368PMID 19309729DOI 10.1002/PRO.82 Variant Set Distributions Mapped Variants
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2c47 CSNK1G2 structure of casein kinase 1 gamma 2 2.4Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,E.UGOCHUKWU,O.FEDOROV,F.SOBOTT,AUTH 2 J.ESWARAN,A.AMOS,L.BALL,F.VON DELFT,A.BULLOCK,J.DEBRECZENI,AUTH 3 A.TURNBULL,M.SUNDSTROM,J.WEIGELT,C.ARROWSMITH,A.EDWARDS,AUTH 4 S.KNAPPTITL THE STRUCTURE OF CASEIN KINASE 1 GAMMA 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants