Assessment of Structural Intolerance and Durability
General Structure Information 3lq3 CHKB crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide 1.42Å AUTH B.S.HONG,A.ALLALI-HASSANI,W.TEMPEL,P.J.FINERTY,F.MACKENZIE,AUTH 2 S.DIMOV,M.VEDADI,H.W.PARKTITL CRYSTAL STRUCTURES OF HUMAN CHOLINE KINASE ISOFORMS INTITL 2 COMPLEX WITH HEMICHOLINIUM-3: SINGLE AMINO ACID NEAR THETITL 3 ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY.REF J.BIOL.CHEM. V. 285 16330 2010REFN ISSN 0021-9258PMID […]
General Structure Information 3ebb PLAA plap/p97 complex 1.9Å AUTH L.QIU,N.PASHKOVA,J.R.WALKER,S.WINISTORFER,A.ALLALI-HASSANI,AUTH 2 M.AKUTSU,R.PIPER,S.DHE-PAGANONTITL STRUCTURE AND FUNCTION OF THE PLAA/UFD3-P97/CDC48 COMPLEX.REF J.BIOL.CHEM. V. 285 365 2010REFN ISSN 0021-9258PMID 19887378DOI 10.1074/JBC.M109.044685 Variant Set Distributions Mapped Variants
General Structure Information 2pid YARS2 crystal structure of human mitochondrial tyrosyl-trna synthetase in complex with an adenylate analog 2.2Å AUTH L.BONNEFOND,M.FRUGIER,E.TOUZE,B.LORBER,C.FLORENTZ,R.GIEGE,AUTH 2 C.SAUTER,J.RUDINGER-THIRIONTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL TYROSYL-TRNATITL 2 SYNTHETASE REVEALS COMMON AND IDIOSYNCRATIC FEATURES.REF STRUCTURE V. 15 1505 2007REFN ISSN 0969-2126PMID 17997975DOI 10.1016/J.STR.2007.09.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3l4g FARSA crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase 3.3Å AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 Variant Set Distributions Mapped Variants
General Structure Information 3a7h STK24 human mst3 kinase in complex with atp 1.96Å AUTH T.P.KO,W.Y.JENG,C.I.LIU,M.D.LAI,C.L.WU,W.J.CHANG,H.L.SHR,AUTH 2 T.J.LU,A.H.J.WANGTITL STRUCTURES OF HUMAN MST3 KINASE IN COMPLEX WITH ADENINE, ADPTITL 2 AND MN2+.REF ACTA CRYSTALLOGR.,SECT.D V. 66 145 2010REFN ISSN 0907-4449PMID 20124694DOI 10.1107/S0907444909047507 Variant Set Distributions Mapped Variants
General Structure Information 2qz4 SPG7 human paraplegin, aaa domain in complex with adp 2.22Å AUTH T.KARLBERG,S.VAN DEN BERG,M.HAMMARSTROM,J.SAGEMARK,AUTH 2 I.JOHANSSON,L.HOLMBERG-SCHIAVONE,H.SCHULERTITL CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF THE HUMAN AAA+TITL 2 PROTEIN PARAPLEGIN/SPG7.REF PLOS ONE V. 4 E6975 2009REFN ESSN 1932-6203PMID 19841671DOI 10.1371/JOURNAL.PONE.0006975 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ex7 RBM8A the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Mapped Variants
General Structure Information 2×18 AKT3 the crystal structure of the ph domain of human akt3 protein kinase 1.46Å AUTH M.VOLLMAR,J.WANG,Y.ZHANG,J.M.ELKINS,N.BURGESS-BROWN,AUTH 2 A.CHAIKUAD,A.C.W.PIKE,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE PH DOMAIN OF HUMAN AKT3TITL 2 PROTEIN KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants