General Structure Information
| PDB ID | 3l4g |
| HGNC Gene Label(s) | FARSA |
| Structure Name | crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase |
| Resolution | 3.3Å |
| Reference | AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 349 |
| Number Of SNVs | 84 |
| Number Of Permutations | 44367 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.052 |
| p-value | 0.828 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 19:13044495 | rs376335677 | V>L | K:6 | (115.37, 30.86, -23.61) |
| 19:13044399 | rs369666428 | V>M | K:38 | (120.25, 31.61, -31.43) |
| 19:13044383 | S>N | K:43 | (120.18, 37.44, -26.30) | |
| 19:13039638 | S>N | K:176 | (126.81, 26.59, -25.47) | |
| 19:13039639 | S>G | K:176 | (126.81, 26.59, -25.47) | |
| 19:13039621 | S>G | K:182 | (119.84, 31.02, -12.66) | |
| 19:13039608 | rs564437437 | S>Y | K:186 | (116.33, 38.80, -13.59) |
| 19:13039466 | R>Q | K:203 | (133.87, 33.38, -13.39) | |
| 19:13039460 | R>Q | K:205 | (127.26, 37.45, -11.64) | |
| 19:13039461 | rs142272380 | R>W | K:205 | (127.26, 37.45, -11.64) |
| 19:13039453 | F>L | K:207 | (127.17, 41.35, -15.82) | |
| 19:13039430 | H>R | K:215 | (124.37, 55.17, -32.08) | |
| 19:13039431 | H>Y | K:215 | (124.37, 55.17, -32.08) | |
| 19:13039428 | G>S | K:216 | (126.78, 56.42, -28.05) | |
| 19:13039421 | rs138804009 | L>R | K:218 | (129.33, 61.40, -28.93) |
| 19:13039416 | D>H | K:220 | (133.08, 66.01, -23.69) | |
| 19:13039411 | S>R | K:221 | (134.95, 67.36, -28.19) | |
| 19:13039397 | P>L | K:226 | (134.60, 74.79, -40.28) | |
| 19:13039382 | COSM1304055 | R>H | K:231 | (142.54, 79.68, -42.14) |
| 19:13039383 | R>C | K:231 | (142.54, 79.68, -42.14) | |
| 19:13039379 | S>C | K:232 | (144.41, 75.49, -42.53) | |
| 19:13039372 | F>L | K:234 | (143.46, 76.96, -49.10) | |
| 19:13039365 | I>V | K:237 | (148.27, 74.16, -50.56) | |
| 19:13039264 | E>K | K:245 | (152.43, 83.55, -44.16) | |
| 19:13039257 | P>L | K:247 | (152.12, 90.11, -43.23) | |
| 19:13039242 | COSM991542 | I>T | K:252 | (142.61, 100.21, -40.71) |
| 19:13039198 | Q>E | K:267 | (137.84, 108.17, -61.26) | |
| 19:13039158 | rs569511768 | R>Q | K:280 | (133.40, 109.14, -38.02) |
| 19:13035982 | rs542928808 | A>V | K:283 | (140.13, 109.33, -41.30) |
| 19:13035973 | L>P | K:286 | (148.90, 109.47, -39.14) | |
| 19:13035962 | rs373922716 | M>V | K:290 | (155.22, 111.21, -49.51) |
| 19:13035952 | V>A | K:293 | (153.15, 109.06, -53.10) | |
| 19:13035928 | S>C | K:301 | (148.42, 112.06, -64.04) | |
| 19:13035923 | G>S | K:303 | (152.70, 109.17, -66.59) | |
| 19:13035920 | rs553871144 | G>S | K:304 | (154.94, 106.51, -67.51) |
| 19:13035914 | rs145222447 | G>S | K:306 | (155.00, 103.80, -70.79) |
| 19:13035812 | K>M | K:311 | (145.36, 111.70, -69.29) | |
| 19:13035799 | K>N | K:315 | (143.11, 115.17, -55.94) | |
| 19:13035797 | rs142135169 | L>P | K:316 | (147.28, 113.76, -51.27) |
| 19:13035795 | D>H | K:317 | (143.57, 115.39, -49.55) | |
| 19:13035789 | A>T | K:319 | (144.77, 109.00, -50.31) | |
| 19:13035782 | K>R | K:321 | (139.87, 109.25, -47.59) | |
| 19:13035773 | L>P | K:324 | (137.78, 98.79, -43.57) | |
| 19:13035761 | T>I | K:328 | (144.32, 90.92, -49.80) | |
| 19:13035743 | R>H | K:334 | (151.96, 97.82, -47.45) | |
| 19:13035740 | A>V | K:335 | (155.09, 93.40, -50.10) | |
| 19:13035731 | R>L | K:338 | (157.81, 95.29, -47.77) | |
| 19:13035732 | rs201276620 | R>C | K:338 | (157.81, 95.29, -47.77) |
| 19:13035726 | A>P | K:340 | (161.77, 96.97, -54.14) | |
| 19:13035722 | rs35087277 | Q>R | K:341 | (163.19, 99.02, -51.45) |
| 19:13035614 | F>S | K:345 | (164.78, 90.92, -57.43) | |
| 19:13035608 | rs139805483 | P>L | K:347 | (163.23, 85.87, -56.48) |
| 19:13035588 | D>N | K:354 | (142.86, 88.46, -44.15) | |
| 19:13035584 | R>H | K:355 | (138.55, 89.23, -41.64) | |
| 19:13035585 | R>C | K:355 | (138.55, 89.23, -41.64) | |
| 19:13035575 | rs371247417 | R>Q | K:358 | (133.96, 94.03, -50.28) |
| 19:13035558 | A>S | K:364 | (122.58, 89.72, -44.57) | |
| 19:13035554 | T>M | K:365 | (122.52, 87.53, -47.64) | |
| 19:13035540 | F>I | K:370 | (134.61, 88.51, -47.75) | |
| 19:13035504 | L>V | K:382 | (156.82, 85.42, -65.03) | |
| 19:13035498 | rs576348484 | L>V | K:384 | (149.57, 84.24, -69.08) |
| 19:13035486 | rs201131468 | M>V | K:388 | (147.87, 79.14, -66.94) |
| 19:13035482 | G>D | K:389 | (150.40, 76.67, -64.03) | |
| 19:13035480 | rs375677041 | V>I | K:390 | (150.79, 78.15, -60.74) |
| 19:13035473 | R>Q | K:392 | (148.00, 72.80, -63.95) | |
| 19:13035474 | COSM1206539 | R>W | K:392 | (148.00, 72.80, -63.95) |
| 19:13035338 | I>V | K:400 | (140.17, 71.17, -59.27) | |
| 19:13035334 | rs570887919 | T>M | K:401 | (141.24, 68.86, -63.36) |
| 19:13035335 | T>S | K:401 | (141.24, 68.86, -63.36) | |
| 19:13035326 | rs537598004 | R>C | K:404 | (137.48, 76.49, -69.95) |
| 19:13035321 | F>L | K:405 | (142.30, 79.44, -67.94) | |
| 19:13035294 | E>D | K:414 | (149.68, 93.05, -67.92) | |
| 19:13035281 | V>L | K:419 | (139.94, 80.38, -63.17) | |
| 19:13035274 | S>N | K:421 | (135.74, 74.47, -62.97) | |
| 19:13035072 | COSM1325471 | K>N | K:427 | (125.72, 69.52, -65.11) |
| 19:13035055 | G>V | K:433 | (139.11, 82.48, -59.83) | |
| 19:13035037 | R>H | K:439 | (149.02, 97.67, -65.55) | |
| 19:13035038 | R>C | K:439 | (149.02, 97.67, -65.55) | |
| 19:13035028 | M>T | K:442 | (151.61, 98.39, -59.56) | |
| 19:13035017 | M>L | K:446 | (156.97, 99.77, -56.30) | |
| 19:13034999 | V>M | K:452 | (160.75, 92.02, -62.55) | |
| 19:13034995 | rs200181672 | S>L | K:453 | (157.44, 89.98, -63.63) |
| 19:13034993 | V>I | K:454 | (154.35, 90.25, -60.65) | |
| 19:13034980 | rs375736391 | G>D | K:458 | (142.29, 84.78, -56.17) |
| 19:13034965 | R>H | K:463 | (133.91, 81.23, -53.83) | |
| 19:13034966 | R>C | K:463 | (133.91, 81.23, -53.83) | |
| 19:13033695 | T>M | K:465 | (133.95, 76.23, -47.43) | |
| 19:13033696 | T>A | K:465 | (133.95, 76.23, -47.43) | |
| 19:13033693 | M>V | K:466 | (129.84, 77.01, -49.36) | |
| 19:13033683 | Y>C | K:469 | (132.72, 71.48, -45.02) | |
| 19:13033677 | rs139040383 | I>T | K:471 | (127.45, 74.54, -46.08) |
| 19:13033665 | R>Q | K:475 | (125.13, 84.96, -42.47) | |
| 19:13033666 | rs373657447 | R>W | K:475 | (125.13, 84.96, -42.47) |
| 19:13033615 | L>V | K:492 | (138.45, 65.68, -41.31) | |
| 19:13033608 | R>H | K:494 | (140.56, 64.27, -46.51) | |
| 19:13033609 | R>C | K:494 | (140.56, 64.27, -46.51) | |
| 19:13033597 | E>K | K:498 | (136.35, 60.71, -54.91) |