Assessment of Structural Intolerance and Durability
General Structure Information 1udw UCK2 crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, ctp 2.6Å AUTH N.N.SUZUKI,K.KOIZUMI,M.FUKUSHIMA,A.MATSUDA,AUTH 2 F.INAGAKITITL STRUCTURAL BASIS FOR THE SPECIFICITY, CATALYSIS,TITL 2 AND REGULATION OF HUMAN URIDINE-CYTIDINE KINASEREF STRUCTURE V. 12 751 2004REFN ISSN 0969-2126PMID 15130468DOI 10.1016/J.STR.2004.02.038 Variant Set Distributions Mapped Variants
General Structure Information 3lj8 DUSP9 crystal structure of mkp-4 2.7Å AUTH D.G.JEONG,T.S.YOON,S.-K.JUNG,B.C.PARK,H.S.PARK,S.E.RYU,AUTH 2 S.J.KIMTITL EXPLORING BINDING SITES OTHER THAN THE CATALYTIC CORE IN THETITL 2 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MKP-4REF ACTA CRYSTALLOGR.,SECT.D V. 67 25 2011REFN ISSN 0907-4449PMID 21206059DOI 10.1107/S0907444910042381 Variant Set Distributions Mapped Variants
General Structure Information 2eax PGLYRP4 crystal structure of human pgrp-ibetac in complex with glycosamyl muramyl pentapeptide 2.1Å AUTH S.CHO,Q.WANG,C.P.SWAMINATHAN,D.HESEK,M.LEE,G.J.BOONS,AUTH 2 S.MOBASHERY,R.A.MARIUZZATITL STRUCTURAL INSIGHTS INTO THE BACTERICIDAL MECHANISM OF HUMANTITL 2 PEPTIDOGLYCAN RECOGNITION PROTEINSREF PROC.NATL.ACAD.SCI.USA V. 104 8761 2007REFN ISSN 0027-8424PMID 17502600DOI 10.1073/PNAS.0701453104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d68 CPB2 crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin- activatable fibrinolysis inhibitor (tafi-iiyq) 2.8Å AUTH P.F.MARX,T.H.BRONDIJK,T.PLUG,R.A.ROMIJN,W.HEMRIKA,AUTH 2 J.C.M.MEIJERS,E.G.HUIZINGATITL CRYSTAL STRUCTURES OF TAFI ELUCIDATE THE INACTIVATIONTITL 2 MECHANISM OF ACTIVATED TAFI: A NOVEL MECHANISM FOR ENZYMETITL 3 AUTOREGULATIONREF BLOOD V. 112 2803 2008REFN ISSN 0006-4971PMID 18559974DOI 10.1182/BLOOD-2008-03-146001 Variant Set Distributions Ripley’s K […]
General Structure Information 1imj ABHD14B crystal structure of the human ccg1/tafii250-interacting factor b (cib) 2.2Å AUTH B.PADMANABHAN,T.KUZUHARA,N.ADACHI,M.HORIKOSHITITL THE CRYSTAL STRUCTURE OFTITL 2 CCG1/TAF(II)250-INTERACTING FACTOR B (CIB)REF J.BIOL.CHEM. V. 279 9615 2004REFN ISSN 0021-9258PMID 14672934DOI 10.1074/JBC.M312165200 Variant Set Distributions Mapped Variants
General Structure Information 2esb DUSP18 crystal structure of human dusp18 2.0Å AUTH D.G.JEONG,Y.H.CHO,T.S.YOON,J.H.KIM,J.H.SON,S.E.RYU,AUTH 2 S.J.KIMTITL STRUCTURE OF HUMAN DSP18, A MEMBER OF THETITL 2 DUAL-SPECIFICITY PROTEIN TYROSINE PHOSPHATASETITL 3 FAMILY.REF ACTA CRYSTALLOGR.,SECT.D V. 62 582 2006REFN ISSN 0907-4449PMID 16699184DOI 10.1107/S0907444906010109 Variant Set Distributions Mapped Variants
General Structure Information 3k2i ACOT4 human acyl-coenzyme a thioesterase 4 2.4Å AUTH M.I.SIPONEN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,P.KRAULIS,T.KOTENYOVA,AUTH 5 A.KOTZSCH,N.MARKOVA,T.K.NIELSEN,P.NORDLUND,T.NYMAN,AUTH 6 C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,AUTH 7 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,AUTH 8 E.WAHLBERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,H.SCHULERTITL HUMAN ACYL-COENZYME A THIOESTERASE 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4emu TMEM173 crystal structure of ligand free human sting 1.9Å AUTH C.SHU,G.YI,T.WATTS,C.C.KAO,P.LITITL STRUCTURE OF STING BOUND TO CYCLIC DI-GMP REVEALS THETITL 2 MECHANISM OF CYCLIC DINUCLEOTIDE RECOGNITION BY THE IMMUNETITL 3 SYSTEM.REF NAT.STRUCT.MOL.BIOL. V. 19 722 2012REFN ISSN 1545-9993PMID 22728658DOI 10.1038/NSMB.2331 Variant Set Distributions Mapped Variants
General Structure Information 3ihy PIK3C3 human pik3c3 crystal structure 2.8Å AUTH M.I.SIPONEN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,AUTH 5 M.MOCHE,T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,AUTH 6 H.SCHUELER,P.SCHUTZ,A.G.THORSELL,S.VAN DEN BERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN PIK3C3 CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2g6z DUSP5 crystal structure of human dusp5 2.7Å AUTH D.G.JEONG,Y.H.CHO,T.S.YOON,J.H.KIM,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 DUSP5, A DUAL SPECIFICITY MAP KINASE PROTEINTITL 3 PHOSPHATASEREF PROTEINS V. 66 253 2007REFN ISSN 0887-3585PMID 17078075DOI 10.1002/PROT.21224 Variant Set Distributions Mapped Variants