General Structure Information
| PDB ID | 3d68 |
| HGNC Gene Label(s) | CPB2 |
| Structure Name | crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin- activatable fibrinolysis inhibitor (tafi-iiyq) |
| Resolution | 2.8Å |
| Reference | AUTH P.F.MARX,T.H.BRONDIJK,T.PLUG,R.A.ROMIJN,W.HEMRIKA,AUTH 2 J.C.M.MEIJERS,E.G.HUIZINGATITL CRYSTAL STRUCTURES OF TAFI ELUCIDATE THE INACTIVATIONTITL 2 MECHANISM OF ACTIVATED TAFI: A NOVEL MECHANISM FOR ENZYMETITL 3 AUTOREGULATIONREF BLOOD V. 112 2803 2008REFN ISSN 0006-4971PMID 18559974DOI 10.1182/BLOOD-2008-03-146001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 400 |
| Number Of SNVs | 83 |
| Number Of Permutations | 40885 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.052 |
| p-value | 0.702 |
COSMIC
| Number Of Residues | 400 |
| Number Of SNVs | 5 |
| Number Of Permutations | 384 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.1 |
| p-value | 0.54 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.422 |
| p-value | 0.476 |