2ESB.A | DUSP18

General Structure Information

PDB ID	2esb
HGNC Gene Label(s)	DUSP18
Structure Name	crystal structure of human dusp18
Resolution	2.0Å
Reference	AUTH D.G.JEONG,Y.H.CHO,T.S.YOON,J.H.KIM,J.H.SON,S.E.RYU,AUTH 2 S.J.KIMTITL STRUCTURE OF HUMAN DSP18, A MEMBER OF THETITL 2 DUAL-SPECIFICITY PROTEIN TYROSINE PHOSPHATASETITL 3 FAMILY.REF ACTA CRYSTALLOGR.,SECT.D V. 62 582 2006REFN ISSN 0907-4449PMID 16699184DOI 10.1107/S0907444906010109

Variant Set Distributions

ExAC Variants

Number Of Residues	162
Number Of SNVs	54
Number Of Permutations	19190
Optimal Distance Threshold	10.0
K Statistic	0.127
p-value	0.2

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
22:31059936		G>S	A:19	(22.40, 35.77, -0.97)
22:31059925		Q>H	A:22	(30.18, 42.41, -2.35)
22:31059924		I>V	A:23	(32.17, 42.47, 2.11)
22:31059917	rs377416793	K>R	A:25	(38.00, 43.56, -4.83)
22:31059906		I>V	A:29	(29.16, 36.89, 3.61)
22:31059899		N>S	A:31	(23.10, 31.36, 3.28)
22:31059888	rs200339726	A>T	A:35	(26.59, 28.22, -1.33)
22:31059860		N>S	A:44	(28.91, 36.79, -8.15)
22:31059857		Q>R	A:45	(33.27, 36.26, -11.14)
22:31059855		I>L	A:46	(32.70, 32.79, -6.59)
22:31059839		N>S	A:51	(32.05, 25.61, 4.95)
22:31059824		V>A	A:56	(26.99, 22.86, 5.88)
22:31059791		M>T	A:67	(37.88, 25.10, 2.64)
22:31059786		V>L	A:69	(36.32, 25.67, 8.96)
22:31059783		P>S	A:70	(35.42, 22.32, 11.27)
22:31059770	rs200899592	S>F	A:74	(30.15, 27.86, 20.28)
22:31059767		P>R	A:75	(30.96, 30.17, 22.74)
22:31059758		R>H	A:78	(40.14, 27.57, 19.70)
22:31059759	rs199672327	R>C	A:78	(40.14, 27.57, 19.70)
22:31059756		L>F	A:79	(36.89, 30.50, 14.72)
22:31059724		H>Q	A:89	(42.94, 31.12, 1.39)
22:31059725		H>R	A:89	(42.94, 31.12, 1.39)
22:31059726		H>D	A:89	(42.94, 31.12, 1.39)
22:31059714		V>M	A:93	(42.16, 34.27, -3.79)
22:31059695	rs200346696 COSM184813	R>H	A:99	(35.56, 37.43, -7.13)
22:31059696		R>C	A:99	(35.56, 37.43, -7.13)
22:31059693		T>S	A:100	(36.25, 34.35, -1.49)
22:31059686	rs146604795	L>R	A:102	(33.18, 33.42, 3.87)
22:31059682		H>Q	A:103	(29.46, 29.11, 3.73)
22:31059684		H>N	A:103	(29.46, 29.11, 3.73)
22:31059681		C>R	A:104	(27.66, 29.53, 7.40)
22:31059669		V>M	A:108	(24.98, 35.40, 11.31)
22:31059665		S>N	A:109	(28.35, 33.92, 13.53)
22:31059662	rs202138261 COSM4103476	R>H	A:110	(29.65, 29.64, 12.06)
22:31059663	rs201450102	R>C	A:110	(29.65, 29.64, 12.06)
22:31059653		A>V	A:113	(34.11, 36.30, 12.28)
22:31059642		A>T	A:117	(39.62, 39.10, 10.81)
22:31059631	rs377209045	M>I	A:120	(41.17, 43.50, 11.56)
22:31059624		H>N	A:123	(41.10, 45.93, 4.08)
22:31059621		A>T	A:124	(43.41, 48.58, 8.20)
22:31059614		S>C	A:126	(38.92, 48.75, 13.50)
22:31059603		A>T	A:130	(34.86, 46.04, 10.51)
22:31059596	rs372836051	T>M	A:132	(30.33, 49.34, 10.79)
22:31059591	rs577122514	T>A	A:134	(30.29, 43.80, 7.69)
22:31059587		K>R	A:135	(25.59, 45.44, 10.25)
22:31059581		C>Y	A:137	(27.21, 44.72, 3.71)
22:31059579		R>W	A:138	(24.87, 39.68, 5.65)
22:31059570		I>V	A:141	(26.30, 40.42, 10.96)
22:31059555	COSM362174	G>S	A:146	(33.10, 34.40, 21.84)
22:31059530	rs201513667	Y>C	A:154	(43.40, 38.85, 15.41)
22:31059514		F>L	A:159	(45.70, 46.98, 15.51)
22:31059515		F>Y	A:159	(45.70, 46.98, 15.51)
22:31059513		G>S	A:160	(47.45, 47.20, 20.82)
22:31059504	rs147361219	T>A	A:163	(37.77, 49.44, 19.22)
22:31059495		M>V	A:166	(33.02, 42.20, 26.09)
22:31059488		S>T	A:168	(27.94, 43.27, 31.61)
22:31059483	rs537667528	P>S	A:170	(20.79, 41.31, 31.03)
22:31059470	rs138771280	I>T	A:174	(27.50, 42.11, 25.34)
22:31059468		P>S	A:175	(29.59, 43.34, 22.50)
22:31059460	rs145909557	I>M	A:177	(28.73, 47.31, 19.52)
22:31059462		I>V	A:177	(28.73, 47.31, 19.52)
22:31059458		Y>C	A:178	(25.83, 43.97, 20.16)