Assessment of Structural Intolerance and Durability
General Structure Information 3bd0 MEMO1 crystal structure of memo, form ii 3.01Å AUTH C.QIU,S.LIENHARD,N.E.HYNES,A.BADACHE,D.J.LEAHYTITL MEMO IS HOMOLOGOUS TO NONHEME IRON DIOXYGENASESTITL 2 AND BINDS AN ERBB2-DERIVED PHOSPHOPEPTIDE IN ITSTITL 3 VESTIGIAL ACTIVE SITE.REF J.BIOL.CHEM. V. 283 2734 2008REFN ISSN 0021-9258PMID 18045866DOI 10.1074/JBC.M703523200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4l9c FBXO7 crystal structure of the fp domain of human f-box protein fbxo7 (native) 2.1Å AUTH J.SHANG,G.WANG,Y.YANG,X.HUANG,Z.DUTITL STRUCTURE OF THE FP DOMAIN OF FBXO7 REVEALS A NOVEL MODE OFTITL 2 PROTEIN-PROTEIN INTERACTION.REF ACTA CRYSTALLOGR.,SECT.D V. 70 155 2014REFN ISSN 0907-4449PMID 24419388DOI 10.1107/S1399004713025820 Variant Set Distributions Mapped Variants
General Structure Information 3g5c ADAM22 structural and biochemical studies on the ectodomain of human adam22 2.36Å AUTH H.LIU,A.SHIM,X.CHEN,X.HETITL STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OFTITL 2 HUMAN ADAM22REF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1×86 ARHGEF12 crystal structure of the dh/ph domains of leukemia-associated rhogef in complex with rhoa 3.22Å AUTH R.KRISTELLY,G.GAO,J.J.TESMERTITL STRUCTURAL DETERMINANTS OF RHOA BINDING AND NUCLEOTIDETITL 2 EXCHANGE IN LEUKEMIA-ASSOCIATED RHO GUANINE-NUCLEOTIDETITL 3 EXCHANGE FACTOR.REF J.BIOL.CHEM. V. 279 47352 2004REFN ISSN 0021-9258PMID 15331592DOI 10.1074/JBC.M406056200 Variant Set Distributions Mapped Variants
General Structure Information 1d4b CIDEB cide-n domain of human cide-b -1.0Å AUTH A.A.LUGOVSKOY,P.ZHOU,J.J.CHOU,J.S.MCCARTY,P.LI,AUTH 2 G.WAGNERTITL SOLUTION STRUCTURE OF THE CIDE-N DOMAIN OF CIDE-BTITL 2 AND A MODEL FOR CIDE-N/CIDE-N INTERACTIONS IN THETITL 3 DNA FRAGMENTATION PATHWAY OF APOPTOSIS.REF CELL(CAMBRIDGE,MASS.) V. 99 747 1999REFN ISSN 0092-8674PMID 10619428DOI 10.1016/S0092-8674(00)81672-4 Variant Set Distributions Mapped Variants
General Structure Information 1jlj GPHN 1.6 angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin 1.6Å AUTH G.SCHWARZ,N.SCHRADER,R.R.MENDEL,H.J.HECHT,AUTH 2 H.SCHINDELINTITL CRYSTAL STRUCTURES OF HUMAN GEPHYRIN AND PLANTTITL 2 CNX1 G DOMAINS: COMPARATIVE ANALYSIS ANDTITL 3 FUNCTIONAL IMPLICATIONS.REF J.MOL.BIOL. V. 312 405 2001REFN ISSN 0022-2836PMID 11554796DOI 10.1006/JMBI.2001.4952 Variant Set Distributions Ripley’s […]
General Structure Information 3pb9 QPCTL crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase in complex with 1-benzylimidazole 1.12Å AUTH K.F.HUANG,S.S.LIAW,W.L.HUANG,C.Y.CHIA,Y.C.LO,Y.L.CHEN,AUTH 2 A.H.J.WANGTITL STRUCTURES OF HUMAN GOLGI-RESIDENT GLUTAMINYL CYCLASE ANDTITL 2 ITS COMPLEXES WITH INHIBITORS REVEAL A LARGE LOOP MOVEMENTTITL 3 UPON INHIBITOR BINDINGREF J.BIOL.CHEM. V. 286 12439 2011REFN ISSN 0021-9258PMID 21288892DOI 10.1074/JBC.M110.208595 […]
General Structure Information 2ai6 PHPT1 solution structure of human phosphohistidine phosphatase 1 -1.0Å AUTH W.GONG,Y.LI,G.CUI,J.HU,H.FANG,C.JIN,B.XIATITL SOLUTION STRUCTURE AND CATALYTIC MECHANISM OFTITL 2 HUMAN PROTEIN HISTIDINE PHOSPHATASE 1.REF BIOCHEM.J. V. 418 337 2009REFN ISSN 0264-6021PMID 18991813DOI 10.1042/BJ20081571 Variant Set Distributions Mapped Variants
General Structure Information 4dpz HRASLS2 crystal structure of human hrasls2 1.25Å AUTH M.GOLCZAK,P.D.KISER,A.E.SEARS,D.T.LODOWSKI,W.S.BLANER,AUTH 2 K.PALCZEWSKITITL STRUCTURAL BASIS FOR THE ACYLTRANSFERASE ACTIVITY OFTITL 2 LECITHIN:RETINOL ACYLTRANSFERASE-LIKE PROTEINS.REF J.BIOL.CHEM. V. 287 23790 2012REFN ISSN 0021-9258PMID 22605381DOI 10.1074/JBC.M112.361550 Variant Set Distributions Mapped Variants
General Structure Information 3hju MGLL crystal structure of human monoglyceride lipase 2.2Å AUTH G.LABAR,C.BAUVOIS,F.BOREL,J.-L.FERRER,J.WOUTERS,D.M.LAMBERTTITL CRYSTAL STRUCTURE OF THE HUMAN MONOACYLGLYCEROL LIPASE, ATITL 2 KEY ACTOR IN ENDOCANNABINOID SIGNALINGREF CHEMBIOCHEM V. 11 218 2010REFN ISSN 1439-4227PMID 19957260DOI 10.1002/CBIC.200900621 Variant Set Distributions Mapped Variants