Assessment of Structural Intolerance and Durability
General Structure Information 2zoq MAPK3 structural dissection of human mitogen-activated kinase erk1 2.39Å AUTH T.KINOSHITA,I.YOSHIDA,S.NAKAE,K.OKITA,M.GOUDA,AUTH 2 M.MATSUBARA,K.YOKOTA,H.ISHIGURO,T.TADATITL CRYSTAL STRUCTURE OF HUMAN MONO-PHOSPHORYLATEDTITL 2 ERK1 AT TYR204REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 377 1123 2008REFN ISSN 0006-291XPMID 18983981DOI 10.1016/J.BBRC.2008.10.127 Variant Set Distributions Mapped Variants
General Structure Information 2z6k RPA2 crystal structure of full-length human rpa14/32 heterodimer 3.0Å AUTH X.DENG,J.E.HABEL,V.KABALEESWARAN,E.H.SNELL,AUTH 2 M.S.WOLD,G.E.BORGSTAHLTITL STRUCTURE OF THE FULL-LENGTH HUMAN RPA14/32TITL 2 COMPLEX GIVES INSIGHTS INTO THE MECHANISM OF DNATITL 3 BINDING AND COMPLEX FORMATIONREF J.MOL.BIOL. V. 374 865 2007REFN ISSN 0022-2836PMID 17976647DOI 10.1016/J.JMB.2007.09.074 Variant Set Distributions Mapped Variants
General Structure Information 3bhm CBR1 crystal structure of human carbonyl reductase 1 in complex with s-hydroxymethylglutathione 1.8Å AUTH R.L.BATEMAN,D.RAUH,B.TAVSHANJIAN,K.M.SHOKATTITL HUMAN CARBONYL REDUCTASE 1 IS ANTITL 2 S-NITROSOGLUTATHIONE REDUCTASEREF J.BIOL.CHEM. V. 283 35756 2008REFN ISSN 0021-9258PMID 18826943DOI 10.1074/JBC.M807125200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hy5 RLBP1 crystal structure of cralbp 3.04Å AUTH X.HE,J.LOBSIGER,A.STOCKERTITL BOTHNIA DYSTROPHY IS CAUSED BY DOMINO-LIKETITL 2 REARRANGEMENTS IN CELLULAR RETINALDEHYDE-BINDINGTITL 3 PROTEIN MUTANT R234W.REF PROC.NATL.ACAD.SCI.USA V. 106 18545 2009REFN ISSN 0027-8424PMID 19846785DOI 10.1073/PNAS.0907454106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2krr NCL solution structure of the rbd1,2 domains from human nucleolin -1.0Å AUTH S.ARUMUGAM,M.C.MILLER,J.MALIEKAL,P.J.BATES,J.O.TRENT,AUTH 2 A.N.LANETITL SOLUTION STRUCTURE OF THE RBD1,2 DOMAINS FROM HUMANTITL 2 NUCLEOLIN.REF J.BIOMOL.NMR V. 47 79 2010REFN ISSN 0925-2738PMID 20376532DOI 10.1007/S10858-010-9412-1 Variant Set Distributions Mapped Variants
General Structure Information 3ii5 BRAF the complex of wild-type b-raf with pyrazolo pyrimidine inhibitor 2.79Å AUTH D.M.BERGER,N.TORRES,M.DUTIA,D.POWELL,G.CISZEWSKI,AUTH 2 A.GOPALSAMY,J.I.LEVIN,K.H.KIM,W.XU,J.WILHELM,Y.HU,AUTH 3 K.COLLINS,L.FELDBERG,S.KIM,E.FROMMER,AUTH 4 D.WOJCIECHOWICZ,R.MALLONTITL NON-HINGE-BINDING PYRAZOLO[1,5-A]PYRIMIDINES ASTITL 2 POTENT B-RAF KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6519 2009REFN ISSN 0960-894XPMID 19864136DOI 10.1016/J.BMCL.2009.10.049 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1fik PFN1 human platelet profilin i crystallized in low salt 2.3Å AUTH A.A.FEDOROV,T.D.POLLARD,S.C.ALMOTITL CRYSTAL STRUCTURE OF HUMAN PROFILIN AT 2.0TITL 2 ANGSTROMS RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vh7 ACYP1 crystal structure of human common-type acylphosphatase 1.45Å AUTH S.Y.LAM,R.C.Y.YEUNG,T.YU,K.SZE,K.B.WONGTITL A RIGIDIFYING SALT-BRIDGE FAVORS THE ACTIVITY OFTITL 2 THERMOPHILIC ENZYME AT HIGH TEMPERATURES AT THE EXPENSE OFTITL 3 LOW-TEMPERATURE ACTIVITY.REF PLOS BIOL. V. 9 1027 2011REFN ISSN 1544-9173PMID 21423654DOI 10.1371/JOURNAL.PBIO.1001027 Variant Set Distributions Mapped Variants
General Structure Information 3bch RPSA crystal structure of the human laminin receptor precursor 2.15Å AUTH K.V.JAMIESON,J.WU,S.R.HUBBARD,D.MERUELOTITL CRYSTAL STRUCTURE OF THE HUMAN LAMININ RECEPTORTITL 2 PRECURSOR.REF J.BIOL.CHEM. V. 283 3002 2008REFN ISSN 0021-9258PMID 18063583DOI 10.1074/JBC.C700206200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants