General Structure Information 3hy4 MTHFS structure of human mthfs with n5-iminium phosphate 2.79Å AUTH D.WU,Y.LI,G.SONG,C.CHENG,R.ZHANG,A.JOACHIMIAK,AUTH 2 N.SHAW,Z.-J.LIUTITL STRUCTURAL BASIS FOR THE INHIBITION OF HUMANTITL 2 5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE BYTITL 3 N10-SUBSTITUTED FOLATE ANALOGUESREF CANCER RES. V. 69 7294 2009REFN ISSN 0008-5472PMID 19738041DOI 10.1158/0008-5472.CAN-09-1927 Variant Set Distributions Mapped Variants
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 2wya HMGCS2 crystal structure of human mitochondrial 3-hydroxy-3- methylglutaryl-coenzyme a synthase 2 (hmgcs2) 1.7Å AUTH N.SHAFQAT,A.TURNBULL,J.ZSCHOCKE,U.OPPERMANN,AUTH 2 W.W.YUETITL CRYSTAL STRUCTURES OF HUMAN HMG-COA SYNTHASETITL 2 ISOFORMS PROVIDE INSIGHTS INTO INHERITEDTITL 3 KETOGENESIS DISORDERS AND INHIBITOR DESIGN.REF J.MOL.BIOL. V. 398 497 2010REFN ISSN 0022-2836PMID 20346956DOI 10.1016/J.JMB.2010.03.034 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k7p FLNA filamin a ig-like domains 16-17 -1.0Å AUTH O.K.HEIKKINEN,S.RUSKAMO,P.V.KONAREV,D.I.SVERGUN,AUTH 2 T.IIVANAINEN,S.M.HEIKKINEN,P.PERMI,H.KOSKELA,AUTH 3 I.KILPELAINEN,J.YLANNETITL ATOMIC STRUCTURES OF TWO NOVEL IMMUNOGLOBULIN-LIKETITL 2 DOMAIN PAIRS IN THE ACTIN CROSS-LINKING PROTEINTITL 3 FILAMINREF J.BIOL.CHEM. V. 284 25450 2009REFN ISSN 0021-9258PMID 19622754DOI 10.1074/JBC.M109.019661 Variant Set Distributions Mapped Variants
General Structure Information 3cnk FLNA crystal structure of the dimerization domain of human filamin a 1.65Å AUTH M.-D.SEO,S.-H.SEOK,H.IM,A.-R.KWON,S.-J.LEE,AUTH 2 H.-R.KIM,Y.CHO,D.PARK,B.-J.LEETITL CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OFTITL 2 HUMAN FILAMIN AREF PROTEINS V. 75 258 2008REFN ISSN 0887-3585PMID 19137608DOI 10.1002/PROT.22336 Variant Set Distributions Mapped Variants
General Structure Information 2k4t VDAC1 solution structure of human vdac-1 in ldao micelles -1.0Å AUTH S.HILLER,R.G.GARCES,T.J.MALIA,V.Y.OREKHOV,AUTH 2 M.COLOMBINI,G.WAGNERTITL SOLUTION STRUCTURE OF THE INTEGRAL HUMAN MEMBRANETITL 2 PROTEIN VDAC-1 IN DETERGENT MICELLES.REF SCIENCE V. 321 1206 2008REFN ISSN 0036-8075PMID 18755977DOI 10.1126/SCIENCE.1161302 Variant Set Distributions Mapped Variants
General Structure Information 2k3t FLNA solution structure of ig-like domain 23 from human filamin a -1.0Å AUTH F.NAKAMURA,O.HEIKKINEN,O.T.PENTIKAINEN,T.M.OSBORN,AUTH 2 K.E.KASZA,D.A.WEITZ,O.KUPIAINEN,P.PERMI,AUTH 3 I.KILPELAINEN,J.YLANNE,J.H.HARTWIG,T.P.STOSSELTITL MOLECULAR BASIS OF FILAMIN A-FILGAP INTERACTIONTITL 2 AND ITS IMPAIRMENT IN CONGENITAL DISORDERSTITL 3 ASSOCIATED WITH FILAMIN A MUTATIONSREF PLOS ONE V. 4 E4928 2009REFN ESSN 1932-6203PMID 19293932DOI 10.1371/JOURNAL.PONE.0004928 Variant Set Distributions Mapped […]
General Structure Information 2wfn FLNA filamin a actin binding domain 3.2Å AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zv6 SERPINB3 crystal structure of human squamous cell carcinoma antigen 1 2.7Å AUTH B.ZHENG,Y.MATOBA,T.KUMAGAI,C.KATAGIRI,T.HIBINO,AUTH 2 M.SUGIYAMATITL CRYSTAL STRUCTURE OF SCCA1 AND INSIGHT ABOUT THETITL 2 INTERACTION WITH JNK1REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 380 143 2009REFN ISSN 0006-291XPMID 19166818DOI 10.1016/J.BBRC.2009.01.057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants