Assessment of Structural Intolerance and Durability
General Structure Information 3l4g FARSA crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase 3.3Å AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 Variant Set Distributions Mapped Variants
General Structure Information 3ex7 RBM8A the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Mapped Variants
General Structure Information 2r13 CISD1 crystal structure of human mitoneet reveals a novel [2fe- 2s] cluster coordination 1.8Å AUTH X.HOU,R.LIU,S.ROSS,E.J.SMART,H.ZHU,W.GONGTITL CRYSTALLOGRAPHIC STUDIES OF HUMAN MITONEETREF J.BIOL.CHEM. V. 282 33242 2007REFN ISSN 0021-9258PMID 17905743DOI 10.1074/JBC.C700172200 Variant Set Distributions Mapped Variants
General Structure Information 3l4g FARSB crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase 3.3Å AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2wvr CDT1 human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 2kje CREBBP nmr structure of cbp taz2 and adenoviral e1a complex -1.0Å AUTH J.C.FERREON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR SUBVERSION OF CELLULAR CONTROLTITL 2 MECHANISMS BY THE ADENOVIRAL E1A ONCOPROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13260 2009REFN ISSN 0027-8424PMID 19651603DOI 10.1073/PNAS.0906770106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 3dqv CUL5 structural insights into nedd8 activation of cullin-ring ligases: conformational control of conjugation 3.0Å AUTH D.M.DUDA,L.A.BORG,D.C.SCOTT,H.W.HUNT,M.HAMMEL,AUTH 2 B.A.SCHULMANTITL STRUCTURAL INSIGHTS INTO NEDD8 ACTIVATION OFTITL 2 CULLIN-RING LIGASES: CONFORMATIONAL CONTROL OFTITL 3 CONJUGATION.REF CELL(CAMBRIDGE,MASS.) V. 134 995 2008REFN ISSN 0092-8674PMID 18805092DOI 10.1016/J.CELL.2008.07.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]