Assessment of Structural Intolerance and Durability
General Structure Information 2zfh CUTA crystal structure of putative cuta1 from homo sapiens at 2.05a resolution 2.05Å AUTH B.BAGAUTDINOV,Y.MATSUURA,S.BAGAUTDINOVA,N.KUNISHIMA,K.YUTANITITL STRUCTURE OF PUTATIVE CUTA1 FROM HOMO SAPIENS DETERMINED ATTITL 2 2.05 A RESOLUTION.REF ACTA CRYSTALLOGR.,SECT.F V. 64 351 2008REFN ESSN 1744-3091PMID 18453701DOI 10.1107/S1744309108009846 Variant Set Distributions Mapped Variants
General Structure Information 3mop IRAK2 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 3uvh CLIC1 crystal structure analysis of e81m mutant of human clic1 1.84Å AUTH D.A.LEGG-ESILVA,S.FANUCCHI,I.A.ACHILONU,M.A.FERNANDES,AUTH 2 S.H.STOYCHEV,H.W.DIRRTITL CRYSTAL STRUCTURE ANALYSIS OF E81M MUTANT OF HUMAN CLIC1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i4i DDX3X crystal structure of human dead-box rna helicase ddx3x 2.2Å AUTH M.HOGBOM,R.COLLINS,S.VAN DEN BERG,R.-M.JENVERT,T.KARLBERG,AUTH 2 T.KOTENYOVA,A.FLORES,G.B.KARLSSON HEDESTAM,AUTH 3 L.H.HOLMBERG SCHIAVONETITL CRYSTAL STRUCTURE OF CONSERVED DOMAINS 1 AND 2 OF THE HUMANTITL 2 DEAD-BOX HELICASE DDX3X IN COMPLEX WITH THE MONONUCLEOTIDETITL 3 AMPREF J.MOL.BIOL. V. 372 150 2007REFN ISSN 0022-2836PMID 17631897DOI 10.1016/J.JMB.2007.06.050 […]
General Structure Information 1w1h PDPK1 crystal structure of the pdk1 pleckstrin homology (ph) domain 1.45Å AUTH D.KOMANDER,A.FAIRSERVICE,M.DEAK,G.S.KULAR,AUTH 2 A.R.PRESCOTT,C.P.DOWNES,S.T.SAFRANY,D.R.ALESSI,AUTH 3 D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE REGULATION OF PDK1 BYTITL 2 PHOSPHOINOSITIDES AND INOSITOL PHOSPHATESREF EMBO J. V. 23 3918 2004REFN ISSN 0261-4189PMID 15457207DOI 10.1038/SJ.EMBOJ.7600379 Variant Set Distributions Mapped Variants
General Structure Information 4o7q AIM2 crystal structure of the f27g aim2 pyrin domain mutant and similarities of its self-association to ded/ded interactions 1.82Å AUTH A.LU,V.KABALEESWARAN,T.FU,V.G.MAGUPALLI,H.WUTITL CRYSTAL STRUCTURE OF THE F27G AIM2 PYD MUTANT ANDTITL 2 SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DEDTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 426 1420 2014REFN ISSN 0022-2836PMID 24406744DOI 10.1016/J.JMB.2013.12.029 Variant Set Distributions […]
General Structure Information 3urf TNFSF11 human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3urf TNFRSF11B human rankl/opg complex 2.7Å AUTH X.D.LUAN,Q.Y.LU,Y.N.JIANG,S.Y.ZHANG,Q.WANG,H.H.YUAN,AUTH 2 W.M.ZHAO,J.W.WANG,X.Q.WANGTITL CRYSTAL STRUCTURE OF HUMAN RANKL COMPLEXED WITH ITS DECOYTITL 2 RECEPTOR OSTEOPROTEGERINREF J.IMMUNOL. V. 189 245 2012REFN ISSN 0022-1767PMID 22664871DOI 10.4049/JIMMUNOL.1103387 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ibx DFFA nmr structure of dff40 and dff45 n-terminal domain complex -1.0Å AUTH P.ZHOU,A.A.LUGOVSKOY,J.S.MCCARTY,P.LI,G.WAGNERTITL SOLUTION STRUCTURE OF DFF40 AND DFF45 N-TERMINALTITL 2 DOMAIN COMPLEX AND MUTUAL CHAPERONE ACTIVITY OFTITL 3 DFF40 AND DFF45.REF PROC.NATL.ACAD.SCI.USA V. 98 6051 2001REFN ISSN 0027-8424PMID 11371636DOI 10.1073/PNAS.111145098 Variant Set Distributions Mapped Variants
General Structure Information 1eih CCL24 solution structure of the human chemokine eotaxin-2 -1.0Å AUTH K.L.MAYER,M.J.STONETITL NMR SOLUTION STRUCTURE AND RECEPTOR PEPTIDETITL 2 BINDING OF THE CC CHEMOKINE EOTAXIN-2.REF BIOCHEMISTRY V. 39 8382 2000REFN ISSN 0006-2960PMID 10913244DOI 10.1021/BI000523J Variant Set Distributions Mapped Variants