Assessment of Structural Intolerance and Durability
General Structure Information 4f14 NEBL structure of the sh3 domain of human nebulette in complex with a peptide of xirp2 1.2Å AUTH S.EULITZ,F.SAUER,M.C.PELISSIER,P.BOISGUERIN,S.MOLT,J.SCHULD,AUTH 2 Z.ORFANOS,R.A.KLEY,R.VOLKMER,M.WILMANNS,G.KIRFEL,AUTH 3 P.F.VAN DER VEN,D.O.FURSTTITL IDENTIFICATION OF XIN-REPEAT PROTEINS AS NOVEL LIGANDS OFTITL 2 THE SH3 DOMAINS OF NEBULIN AND NEBULETTE AND ANALYSIS OFTITL 3 THEIR INTERACTION DURING MYOFIBRIL FORMATION AND […]
General Structure Information 2wvr GMNN human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 4ec8 CCNT1 structure of full length cdk9 in complex with cyclint and drb 3.6Å AUTH S.BAUMLI,A.J.HOLE,L.Z.WANG,M.E.NOBLE,J.A.ENDICOTTTITL THE CDK9 TAIL DETERMINES THE REACTION PATHWAY OF POSITIVETITL 2 TRANSCRIPTION ELONGATION FACTOR B.REF STRUCTURE V. 20 1788 2012REFN ISSN 0969-2126PMID 22959624DOI 10.1016/J.STR.2012.08.011 Variant Set Distributions Mapped Variants
General Structure Information 1wfq CSDE1 solution structure of the first cold-shock domain of the human kiaa0885 protein (unr protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.INOUE,AUTH 2 S.WATANABE,T.HARADA,A.TANAKA,O.OHARA,T.KIGAWA,S.YOKOYAMATITL THE NMR SOLUTION STRUCTURES OF THE FIVE CONSTITUENTTITL 2 COLD-SHOCK DOMAINS (CSD) OF THE HUMAN UNR (UPSTREAM OFTITL 3 N-RAS) PROTEIN.REF J.STRUCT.FUNCT.GENOM. V. 11 181 2010REFN ISSN 1345-711XPMID 20213426DOI 10.1007/S10969-010-9081-Z Variant […]
General Structure Information 2ox0 KDM4A crystal structure of jmjd2a complexed with histone h3 peptide dimethylated at lys9 1.95Å AUTH S.S.NG,K.L.KAVANAGH,M.A.MCDONOUGH,D.BUTLER,E.S.PILKA,AUTH 2 B.M.LIENARD,J.E.BRAY,P.SAVITSKY,O.GILEADI,F.VON DELFT,AUTH 3 N.R.ROSE,J.OFFER,J.C.SCHEINOST,T.BOROWSKI,M.SUNDSTROM,AUTH 4 C.J.SCHOFIELD,U.OPPERMANNTITL CRYSTAL STRUCTURES OF HISTONE DEMETHYLASE JMJD2A REVEALTITL 2 BASIS FOR SUBSTRATE SPECIFICITY.REF NATURE V. 448 87 2007REFN ISSN 0028-0836PMID 17589501DOI 10.1038/NATURE05971 Variant Set Distributions Mapped Variants
General Structure Information 1imh NFAT5 tonebp/dna complex 2.86Å AUTH J.C.STROUD,C.LOPEZ-RODRIGUEZ,A.RAO,L.CHENTITL STRUCTURE OF A TONEBP-DNA COMPLEX REVEALS DNATITL 2 ENCIRCLED BY A TRANSCRIPTION FACTOR.REF NAT.STRUCT.BIOL. V. 9 90 2002REFN ISSN 1072-8368PMID 11780147DOI 10.1038/NSB749 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2mbc PTP4A3 solution structure of human holo-prl-3 in complex with vanadate -1.0Å AUTH K.KIM,J.H.SONG,J.JEE,M.R.SHEEN,C.LEE,T.G.LEE,S.RO,J.M.CHO,AUTH 2 W.LEE,T.YAMAZAKI,Y.H.JEON,C.CHEONGTITL STRUCTURE OF HUMAN PRL-3, THE PHOSPHATASE ASSOCIATED WITHTITL 2 CANCER METASTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kng LGR5 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mr7 GABBR2 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp54626 2.15Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1n0z ZRANB2 solution structure of the first zinc-finger domain from znf265 -1.0Å AUTH C.A.PLAMBECK,A.H.Y.KWAN,D.J.ADAMS,B.J.WESTMAN,AUTH 2 L.VAN DER WEYDEN,R.L.MEDCALF,B.J.MORRIS,J.P.MACKAYTITL THE STRUCTURE OF THE ZINC FINGER DOMAIN FROM HUMANTITL 2 SPLICING FACTOR ZNF265 FOLDREF J.BIOL.CHEM. V. 278 22805 2003REFN ISSN 0021-9258PMID 12657633DOI 10.1074/JBC.M301896200 Variant Set Distributions Mapped Variants