Assessment of Structural Intolerance and Durability
General Structure Information 1uch UCHL3 deubiquitinating enzyme uch-l3 (human) at 1.8 angstrom resolution 1.8Å AUTH S.C.JOHNSTON,C.N.LARSEN,W.J.COOK,K.D.WILKINSON,AUTH 2 C.P.HILLTITL CRYSTAL STRUCTURE OF A DEUBIQUITINATING ENZYMETITL 2 (HUMAN UCH-L3) AT 1.8 A RESOLUTION.REF EMBO J. V. 16 3787 1997REFN ISSN 0261-4189PMID 9233788DOI 10.1093/EMBOJ/16.13.3787 Variant Set Distributions Mapped Variants
General Structure Information 2eyi ACTN1 crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 angstrom resolution 1.7Å AUTH E.BORREGO-DIAZ,F.KERFF,S.H.LEE,F.FERRON,Y.LI,AUTH 2 R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ 1: EVALUATING TWO COMPETINGTITL 3 ACTIN-BINDING MODELS.REF J.STRUCT.BIOL. V. 155 230 2006REFN ISSN 1047-8477PMID 16698282DOI 10.1016/J.JSB.2006.01.013 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 2ygg SLC9A1 complex of cambr and cam 2.23Å AUTH S.KOESTER,T.PAVKOV-KELLER,W.KUEHLBRANDT,O.YILDIZTITL STRUCTURE OF HUMAN NA+/H+ EXCHANGER NHE1 REGULATORY REGIONTITL 2 IN COMPLEX WITH CAM AND CA2+REF J.BIOL.CHEM. V. 286 40954 2011REFN ISSN 0021-9258PMID 21931166DOI 10.1074/JBC.M111.286906 Variant Set Distributions Mapped Variants
General Structure Information 2ror VAV1 solution structure of the vav1 sh2 domain complexed with a tyrosine-phosphorylated peptide from slp76 -1.0Å AUTH T.KASAI,M.TANAKA,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE VAV1 SH2 DOMAINTITL 2 COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDETITL 3 FROM SLP76REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3w4i DAO crystal structure of human daao in complex with coumpound 8 2.5Å AUTH T.HONDO,M.WARIZAYA,T.NIIMI,I.NAMATAME,T.YAMAGUCHI,AUTH 2 K.NAKANISHI,T.HAMAJIMA,K.HARADA,H.SAKASHITA,Y.MATSUMOTO,AUTH 3 M.ORITA,M.TAKEUCHITITL 4-HYDROXYPYRIDAZIN-3(2H)-ONE DERIVATIVES AS NOVEL D-AMINOTITL 2 ACID OXIDASE INHIBITORS.REF J.MED.CHEM. V. 56 3582 2013REFN ISSN 0022-2623PMID 23566269DOI 10.1021/JM400095B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1evs OSM crystal structure of human oncostatin m 2.2Å AUTH M.C.DELLER,K.R.HUDSON,S.IKEMIZU,J.BRAVO,E.Y.JONES,AUTH 2 J.K.HEATHTITL CRYSTAL STRUCTURE AND FUNCTIONAL DISSECTION OF THETITL 2 CYTOSTATIC CYTOKINE ONCOSTATIN M.REF STRUCTURE FOLD.DES. V. 8 863 2000REFN ISSN 0969-2126PMID 10997905DOI 10.1016/S0969-2126(00)00176-3 Variant Set Distributions Mapped Variants
General Structure Information 3v4v ITGA4 crystal structure of a4b7 headpiece complexed with fab act-1 and ro0505376 3.1Å AUTH Y.YU,J.ZHU,L.Z.MI,T.WALZ,H.SUN,J.CHEN,T.A.SPRINGERTITL STRUCTURAL SPECIALIZATIONS OF A4B7, AN INTEGRIN THATTITL 2 MEDIATES ROLLING ADHESIONREF J.CELL BIOL. V. 196 131 2012REFN ISSN 0021-9525PMID 22232704DOI 10.1083/JCB.201110023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dzu RXRA intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide 3.2Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 2nsm CPN1 crystal structure of the human carboxypeptidase n (kininase i) catalytic domain 2.1Å AUTH C.KEIL,K.MASKOS,M.THAN,J.T.HOOPES,R.HUBER,F.TAN,P.A.DEDDISH,AUTH 2 E.G.ERDOES,R.A.SKIDGEL,W.BODETITL CRYSTAL STRUCTURE OF THE HUMAN CARBOXYPEPTIDASE N (KININASETITL 2 I) CATALYTIC DOMAINREF J.MOL.BIOL. V. 366 504 2007REFN ISSN 0022-2836PMID 17157876DOI 10.1016/J.JMB.2006.11.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4jqg MMP9 crystal structure of an inactive mutant of mmp-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom. 1.85Å AUTH I.TRANCHANT,L.VERA,B.CZARNY,M.AMOURA,E.CASSAR,F.BEAU,AUTH 2 E.A.STURA,V.DIVETITL HALOGEN BONDING CONTROLS SELECTIVITY OF FRET SUBSTRATETITL 2 PROBES FOR MMP-9.REF CHEM.BIOL. V. 21 408 2014REFN ISSN 1074-5521PMID 24583051DOI 10.1016/J.CHEMBIOL.2014.01.008 Variant Set Distributions […]