General Structure Information
| PDB ID | 3w4i |
| HGNC Gene Label(s) | DAO |
| Structure Name | crystal structure of human daao in complex with coumpound 8 |
| Resolution | 2.5Å |
| Reference | AUTH T.HONDO,M.WARIZAYA,T.NIIMI,I.NAMATAME,T.YAMAGUCHI,AUTH 2 K.NAKANISHI,T.HAMAJIMA,K.HARADA,H.SAKASHITA,Y.MATSUMOTO,AUTH 3 M.ORITA,M.TAKEUCHITITL 4-HYDROXYPYRIDAZIN-3(2H)-ONE DERIVATIVES AS NOVEL D-AMINOTITL 2 ACID OXIDASE INHIBITORS.REF J.MED.CHEM. V. 56 3582 2013REFN ISSN 0022-2623PMID 23566269DOI 10.1021/JM400095B |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 340 |
| Number Of SNVs | 94 |
| Number Of Permutations | 54124 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.396 |
| p-value | 0.334 |
COSMIC
| Number Of Residues | 340 |
| Number Of SNVs | 13 |
| Number Of Permutations | 11632 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.154 |
| p-value | 0.947 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 94 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | -0.143 |
| p-value | 0.737 |