Assessment of Structural Intolerance and Durability
General Structure Information 3hlk ACOT2 crystal structure of human mitochondrial acyl-coa thioesterase (acot2) 2.1Å AUTH C.R.MANDEL,B.TWEEL,L.TONGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ACYL-COATITL 2 THIOESTERASE (ACOT2)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 385 630 2009REFN ISSN 0006-291XPMID 19497300DOI 10.1016/J.BBRC.2009.05.122 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4aqp ATXN1 the structure of the axh domain of ataxin-1. 2.45Å AUTH C.DE CHIARA,M.REES,R.P.MENON,K.PAUWELS,C.LAWRENCE,AUTH 2 P.V.KONAREV,D.I.SVERGUN,S.R.MARTIN,Y.W.CHEN,A.PASTORETITL SELF-ASSEMBLY AND CONFORMATIONAL HETEROGENEITY OF THE AXHTITL 2 DOMAIN OF ATAXIN-1: AN UNUSUAL EXAMPLE OF A CHAMELEON FOLDREF BIOPHYS.J. V. 104 1304 2013REFN ISSN 0006-3495PMID 23528090DOI 10.1016/J.BPJ.2013.01.048 Variant Set Distributions Mapped Variants
General Structure Information 1eot CCL11 solution nmr structure of eotaxin, minimized average structure -1.0Å AUTH M.P.CRUMP,K.RAJARATHNAM,K.S.KIM,I.CLARK-LEWIS,AUTH 2 B.D.SYKESTITL SOLUTION STRUCTURE OF EOTAXIN, A CHEMOKINE THATTITL 2 SELECTIVELY RECRUITS EOSINOPHILS IN ALLERGICTITL 3 INFLAMMATION.REF J.BIOL.CHEM. V. 273 22471 1998REFN ISSN 0021-9258PMID 9712872DOI 10.1074/JBC.273.35.22471 Variant Set Distributions Mapped Variants
General Structure Information 3caq AKR1D1 crystal structure of 5beta-reductase (akr1d1) in complex with nadph 2.2Å AUTH F.FAUCHER,L.CANTIN,V.LUU-THE,F.LABRIE,R.BRETONTITL CRYSTAL STRUCTURES OF HUMAN DELTA4-3-KETOSTEROIDTITL 2 5BETA-REDUCTASE (AKR1D1) REVEAL THE PRESENCE OF ANTITL 3 ALTERNATIVE BINDING SITE RESPONSIBLE FOR SUBSTRATETITL 4 INHIBITION (DAGGER) (,) (DOUBLE DAGGER).REF BIOCHEMISTRY V. 47 13537 2008REFN ISSN 0006-2960PMID 19075558DOI 10.1021/BI801276H Variant Set Distributions […]
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 2lnx VAV2 solution structure of vav2 sh2 domain -1.0Å AUTH B.WU,F.WANG,J.ZHANG,Z.ZHANG,L.QIN,J.PENG,F.LI,J.LIU,G.LU,AUTH 2 Q.GONG,X.YAO,J.WU,Y.SHITITL IDENTIFICATION AND STRUCTURAL BASIS FOR A NOVEL INTERACTIONTITL 2 BETWEEN VAV2 AND ARAP3.REF J.STRUCT.BIOL. V. 180 84 2012REFN ISSN 1047-8477PMID 22750419DOI 10.1016/J.JSB.2012.06.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l2p LIG3 human dna ligase iii recognizes dna ends by dynamic switching between two dna bound states 3.0Å AUTH E.COTNER-GOHARA,I.K.KIM,M.HAMMEL,J.A.TAINER,A.E.TOMKINSON,AUTH 2 T.ELLENBERGERTITL HUMAN DNA LIGASE III RECOGNIZES DNA ENDS BY DYNAMICTITL 2 SWITCHING BETWEEN TWO DNA-BOUND STATES.REF BIOCHEMISTRY V. 49 6165 2010REFN ISSN 0006-2960PMID 20518483DOI 10.1021/BI100503W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1cjy PLA2G4A human cytosolic phospholipase a2 2.5Å AUTH A.DESSEN,J.TANG,H.SCHMIDT,M.STAHL,J.D.CLARK,AUTH 2 J.SEEHRA,W.S.SOMERSTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC PHOSPHOLIPASETITL 2 A2 REVEALS A NOVEL TOPOLOGY AND CATALYTICTITL 3 MECHANISM.REF CELL(CAMBRIDGE,MASS.) V. 97 349 1999REFN ISSN 0092-8674PMID 10319815DOI 10.1016/S0092-8674(00)80744-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1egx VASP solution structure of the ena-vasp homology 1 (evh1) domain of human vasodilator-stimulated phosphoprotein (vasp) -1.0Å AUTH L.J.BALL,R.KUHNE,B.HOFFMANN,A.HAFNER,P.SCHMIEDER,AUTH 2 R.VOLKMER-ENGERT,M.HOF,M.WAHL,J.SCHNEIDER-MERGENER,U.WALTER,AUTH 3 H.OSCHKINAT,T.JARCHAUTITL DUAL EPITOPE RECOGNITION BY THE VASP EVH1 DOMAIN MODULATESTITL 2 POLYPROLINE LIGAND SPECIFICITY AND BINDING AFFINITY.REF EMBO J. V. 19 4903 2000REFN ISSN 0261-4189PMID 10990454DOI 10.1093/EMBOJ/19.18.4903 Variant Set Distributions […]
General Structure Information 2c9y AK2 structure of human adenylate kinase 2 2.1Å AUTH G.BUNKOCZI,P.FILIPPAKOPOULOS,J.E.DEBRECZENI,A.TURNBULL,AUTH 2 E.PAPAGRIGORIOU,P.SAVITSKY,S.COLEBROOK,F.VON DELFT,AUTH 3 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN ADENYLATE KINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants