Assessment of Structural Intolerance and Durability
General Structure Information 3mx0 EFNA5 crystal structure of epha2 ectodomain in complex with ephrin-a5 3.51Å AUTH J.P.HIMANEN,L.YERMEKBAYEVA,P.W.JANES,J.R.WALKER,K.XU,AUTH 2 L.ATAPATTU,K.R.RAJASHANKAR,A.MENSINGA,M.LACKMANN,AUTH 3 D.B.NIKOLOV,S.DHE-PAGANONTITL ARCHITECTURE OF EPH RECEPTOR CLUSTERS.REF PROC.NATL.ACAD.SCI.USA V. 107 10860 2010REFN ISSN 0027-8424PMID 20505120DOI 10.1073/PNAS.1004148107 Variant Set Distributions Mapped Variants
General Structure Information 3frs IST1 structure of human ist1(ntd) (residues 1-189)(p43212) 2.61Å AUTH M.BAJOREK,H.L.SCHUBERT,J.MCCULLOUGH,C.LANGELIER,D.M.ECKERT,AUTH 2 W.M.STUBBLEFIELD,N.T.UTER,D.G.MYSZKA,C.P.HILL,W.I.SUNDQUISTTITL STRUCTURAL BASIS FOR ESCRT-III PROTEIN AUTOINHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 16 754 2009REFN ISSN 1545-9993PMID 19525971DOI 10.1038/NSMB.1621 Variant Set Distributions Mapped Variants
General Structure Information 1jkw CCNH structure of cyclin mcs2 2.6Å AUTH G.ANDERSEN,A.POTERSZMAN,J.M.EGLY,D.MORAS,AUTH 2 J.C.THIERRYTITL THE CRYSTAL STRUCTURE OF HUMAN CYCLIN H.REF FEBS LETT. V. 397 65 1996REFN ISSN 0014-5793PMID 8941715DOI 10.1016/S0014-5793(96)01143-X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o96 PSMD7 crystal structure of the metal-free dimeric human mov34 mpn domain (residues 1-177) 3.0Å AUTH M.SANCHES,B.S.C.ALVES,N.I.T.ZANCHIN,B.G.GUIMARAESTITL THE CRYSTAL STRUCTURE OF THE HUMAN MOV34 MPN DOMAIN REVEALSTITL 2 A METAL-FREE DIMERREF J.MOL.BIOL. V. 370 846 2007REFN ISSN 0022-2836PMID 17559875DOI 10.1016/J.JMB.2007.04.084 Variant Set Distributions Mapped Variants
General Structure Information 2ckj XDH human milk xanthine oxidoreductase 3.59Å AUTH A.R.PEARSON,B.L.J.GODBER,R.EISENTHAL,G.L.TAYLOR,AUTH 2 R.HARRISONTITL HUMAN MILK XANTHINE DEHYDROGENASE IS INCOMPLETELYTITL 2 CONVERTED TO THE OXIDASE FORM IN THE ABSENCE OFTITL 3 PROTEOLYSIS. A STRUCTURAL EXPLANATION.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ihi AKR1C2 crystal structure of human type iii 3-alpha-hydroxysteroid dehydrogenase/bile acid binding protein (akr1c2) complexed with nadp+ and ursodeoxycholate 3.0Å AUTH Y.JIN,S.E.STAYROOK,R.H.ALBERT,N.T.PALACKAL,AUTH 2 T.M.PENNING,M.LEWISTITL CRYSTAL STRUCTURE OF HUMAN TYPE IIITITL 2 3ALPHA-HYDROXYSTEROID DEHYDROGENASE/BILE ACIDTITL 3 BINDING PROTEIN COMPLEXED WITH NADP(+) ANDTITL 4 URSODEOXYCHOLATE.REF BIOCHEMISTRY V. 40 10161 2001REFN ISSN 0006-2960PMID 11513593DOI 10.1021/BI010919A […]
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kkd MASP1 the x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3mc syndrome 2.6Å AUTH T.YONGQING,P.G.WILMANN,S.B.REEVE,T.H.COETZER,A.I.SMITH,AUTH 2 J.C.WHISSTOCK,R.N.PIKE,L.C.WIJEYEWICKREMATITL THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDINGTITL 2 LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURALTITL 3 BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE CARNEVALE,TITL 4 MINGARELLI, […]
General Structure Information 2hgm HNRNPF nmr structure of the second qrrm domain of human hnrnp f -1.0Å AUTH C.DOMINGUEZ,F.H.ALLAINTITL NMR STRUCTURE OF THE THREE QUASI RNA RECOGNITIONTITL 2 MOTIFS (QRRMS) OF HUMAN HNRNP F AND INTERACTIONTITL 3 STUDIES WITH BCL-X G-TRACT RNA: A NOVEL MODE OFTITL 4 RNA RECOGNITION.REF NUCLEIC ACIDS RES. V. 34 3634 […]
General Structure Information 3uio RANBP2 complex between human rangap1-sumo2, ubc9 and the ir1 domain from ranbp2 containing ir2 motif ii 2.6Å AUTH J.R.GAREAU,D.REVERTER,C.D.LIMATITL DETERMINANTS OF SMALL UBIQUITIN-LIKE MODIFIER 1 (SUMO1)TITL 2 PROTEIN SPECIFICITY, E3 LIGASE, AND SUMO-RANGAP1 BINDINGTITL 3 ACTIVITIES OF NUCLEOPORIN RANBP2.REF J.BIOL.CHEM. V. 287 4740 2012REFN ISSN 0021-9258PMID 22194619DOI 10.1074/JBC.M111.321141 Variant Set Distributions […]