Assessment of Structural Intolerance and Durability
General Structure Information 2i0e PRKCB structure of catalytic domain of human protein kinase c beta ii complexed with a bisindolylmaleimide inhibitor 2.6Å AUTH N.GRODSKY,Y.LI,D.BOUZIDA,R.LOVE,J.JENSEN,B.NODES,AUTH 2 J.NONOMIYA,S.GRANTTITL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 KINASE C BETA II COMPLEXED WITH ATITL 3 BISINDOLYLMALEIMIDE INHIBITORREF BIOCHEMISTRY V. 45 13970 2006REFN ISSN 0006-2960PMID 17115692DOI 10.1021/BI061128H Variant […]
General Structure Information 2anw KLKB1 expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: implications for structure-based design of protease inhibitors 1.85Å AUTH J.TANG,C.L.YU,S.R.WILLIAMS,E.SPRINGMAN,D.JEFFERY,AUTH 2 P.A.SPRENGELER,A.ESTEVEZ,J.SAMPANG,W.SHRADER,AUTH 3 J.SPENCER,W.YOUNG,M.MCGRATH,B.A.KATZTITL EXPRESSION, CRYSTALLIZATION, AND THREE-DIMENSIONALTITL 2 STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMATITL 3 KALLIKREIN.REF J.BIOL.CHEM. V. 280 41077 2005REFN ISSN 0021-9258PMID 16199530DOI […]
General Structure Information 3gxm GBA crystal structure of acid-beta-glucosidase at ph 4.5, phosphate crystallization condition 2.2Å AUTH R.L.LIEBERMAN,J.A.DAQUINO,D.RINGE,G.A.PETSKOTITL EFFECTS OF PH AND IMINOSUGAR PHARMACOLOGICAL CHAPERONES ONTITL 2 LYSOSOMAL GLYCOSIDASE STRUCTURE AND STABILITY.REF BIOCHEMISTRY V. 48 4816 2009REFN ISSN 0006-2960PMID 19374450DOI 10.1021/BI9002265 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z7c CSH1 crystal structure of human placental lactogen 2.0Å AUTH S.T.R.WALSH,A.A.KOSSIAKOFFTITL CRYSTAL STRUCTURE AND SITE 1 BINDING ENERGETICS OF HUMANTITL 2 PLACENTAL LACTOGEN.REF J.MOL.BIOL. V. 358 773 2006REFN ISSN 0022-2836PMID 16546209DOI 10.1016/J.JMB.2006.02.038 Variant Set Distributions Mapped Variants
General Structure Information 2knc ITGB3 platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1if4 CA2 carbonic anhydrase ii complexed with 4- fluorobenzenesulfonamide 1.93Å AUTH C.-Y.KIM,D.W.CHRISTIANSONTITL BINDING OF FLUORINE SUBSTITUTEDTITL 2 BENZENESULFONAMIDES TO CARBONIC ANHYDRASE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fos JUN two human c-fos:c-jun:dna complexes 3.05Å AUTH J.N.GLOVER,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC BZIPTITL 2 TRANSCRIPTION FACTOR C-FOS-C-JUN BOUND TO DNA.REF NATURE V. 373 257 1995REFN ISSN 0028-0836PMID 7816143DOI 10.1038/373257A0 Variant Set Distributions Mapped Variants
General Structure Information 1fos FOS two human c-fos:c-jun:dna complexes 3.05Å AUTH J.N.GLOVER,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC BZIPTITL 2 TRANSCRIPTION FACTOR C-FOS-C-JUN BOUND TO DNA.REF NATURE V. 373 257 1995REFN ISSN 0028-0836PMID 7816143DOI 10.1038/373257A0 Variant Set Distributions Mapped Variants
General Structure Information 2dyq APBB3 crystal structure of the c-terminal phophotyrosine interaction domain of human apbb3 3.1Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE C-TERMINAL PHOPHOTYROSINETITL 2 INTERACTION DOMAIN OF HUMAN APBB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dmu VWF crystal structure of the von willebrand factor a3 domain in complex with a collagen iii derived triple-helical peptide 2.8Å AUTH T.H.BRONDIJK,D.BIHAN,R.W.FARNDALE,E.G.HUIZINGATITL IMPLICATIONS FOR COLLAGEN I CHAIN REGISTRY FROM THETITL 2 STRUCTURE OF THE COLLAGEN VON WILLEBRAND FACTOR A3 DOMAINTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 5253 2012REFN ISSN 0027-8424PMID 22440751DOI 10.1073/PNAS.1112388109 […]