3PRY.A | HSP90AB1

General Structure Information 3pry HSP90AB1 crystal structure of the middle domain of human hsp90-beta refined at 2.3 a resolution 2.28Å AUTH A.CHAIKUAD,E.PILKA,T.D.SHARPE,C.D.O.COOPER,C.PHILLIPS,AUTH 2 G.BERRIDGE,V.AYINAMPUDI,O.FEDOROV,T.KEATES,AUTH 3 C.THANGARATNARAJAH,T.ZIMMERMANN,M.VOLLMAR,W.W.YUE,K.H.CHE,AUTH 4 T.KROJER,J.R.C.MUNIZ,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 5 J.WEIGELT,A.EDWARDS,A.BULLOCK,AUTH 6 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETATITL 2 REFINED AT 2.3 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant […]

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1QKI.D | G6PD

General Structure Information 1qki G6PD x-ray structure of human glucose 6-phosphate dehydrogenase (variant canton r459l) complexed with structural nadp+ 3.0Å AUTH S.W.N.AU,S.GOVER,V.M.S.LAM,M.J.ADAMSTITL HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE: THETITL 2 CRYSTAL STRUCTURE REVEALS A STRUCTURAL NADP+TITL 3 MOLECULE AND PROVIDES INSIGHTS INTO ENZYMETITL 4 DEFICIENCYREF STRUCTURE V. 8 293 2000REFN ISSN 0969-2126PMID 10745013DOI 10.1016/S0969-2126(00)00104-0 Variant Set Distributions Ripley’s […]

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3SGJ.C | FCGR3A

General Structure Information 3sgj FCGR3A unique carbohydrate-carbohydrate interactions are required for high affinity binding between fcgiii and antibodies lacking core fucose 2.2Å AUTH C.FERRARA,S.GRAU,C.JAGER,P.SONDERMANN,P.BRUNKER,I.WALDHAUER,AUTH 2 M.HENNIG,A.RUF,A.C.RUFER,M.STIHLE,P.UMANA,J.BENZTITL UNIQUE CARBOHYDRATE-CARBOHYDRATE INTERACTIONS ARE REQUIREDTITL 2 FOR HIGH AFFINITY BINDING BETWEEN FCGAMMARIII AND ANTIBODIESTITL 3 LACKING CORE FUCOSE.REF PROC.NATL.ACAD.SCI.USA V. 108 12669 2011REFN ISSN 0027-8424PMID 21768335DOI 10.1073/PNAS.1108455108 Variant Set […]

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3A8Y.A | HSPA1A

General Structure Information 3a8y HSPA1A crystal structure of the complex between the bag5 bd5 and hsp70 nbd 2.3Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants

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3O8Y.B | ALOX5

General Structure Information 3o8y ALOX5 stable-5-lipoxygenase 2.39Å AUTH N.C.GILBERT,S.G.BARTLETT,M.T.WAIGHT,D.B.NEAU,W.E.BOEGLIN,AUTH 2 A.R.BRASH,M.E.NEWCOMERTITL THE STRUCTURE OF HUMAN 5-LIPOXYGENASE.REF SCIENCE V. 331 217 2011REFN ISSN 0036-8075PMID 21233389DOI 10.1126/SCIENCE.1197203 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3NMQ.A | HSP90AB1

General Structure Information 3nmq HSP90AB1 hsp90b n-terminal domain in complex with ec44, a pyrrolo-pyrimidine methoxypyridine inhibitor 2.2Å AUTH T.J.YUN,E.K.HARNING,K.GIZA,D.RABAH,P.LI,J.W.ARNDT,AUTH 2 D.LUCHETTI,M.A.BIAMONTE,J.SHI,K.LUNDGREN,A.MANNING,M.R.KEHRYTITL EC144, A SYNTHETIC INHIBITOR OF HEAT SHOCK PROTEIN 90,TITL 2 BLOCKS INNATE AND ADAPTIVE IMMUNE RESPONSES IN MODELS OFTITL 3 INFLAMMATION AND AUTOIMMUNITY.REF J.IMMUNOL. V. 186 563 2011REFN ISSN 0022-1767PMID 21131419DOI 10.4049/JIMMUNOL.1000222 Variant Set […]

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2C0O.B | HCK

General Structure Information 2c0o HCK src family kinase hck with bound inhibitor a-770041 2.85Å AUTH A.BURCHAT,D.W.BORHANI,D.J.CALDERWOOD,G.C.HIRST,B.LI,AUTH 2 R.F.STACHLEWITZTITL DISCOVERY OF A-770041, A SRC-FAMILY SELECTIVE ORALLY ACTIVETITL 2 LCK INHIBITOR THAT PREVENTS ORGAN ALLOGRAFT REJECTION.REF BIOORG.MED.CHEM.LETT. V. 16 118 2006REFN ISSN 0960-894XPMID 16216497DOI 10.1016/J.BMCL.2005.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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2ZM1.A | LCK

General Structure Information 2zm1 LCK crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) 2.1Å AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. […]

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1B0F.A | ELANE

General Structure Information 1b0f ELANE crystal structure of human neutrophil elastase with mdl 101, 146 3.0Å AUTH R.J.CREGGE,S.L.DURHAM,R.A.FARR,S.L.GALLION,C.M.HARE,AUTH 2 R.V.HOFFMAN,M.J.JANUSZ,H.O.KIM,J.R.KOEHL,S.MEHDI,W.A.METZ,AUTH 3 N.P.PEET,J.T.PELTON,H.A.SCHREUDER,S.SUNDER,C.TARDIFTITL INHIBITION OF HUMAN NEUTROPHIL ELASTASE. 4. DESIGN,TITL 2 SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, ANDTITL 3 STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OFTITL 4 P2-MODIFIED, ORALLY ACTIVE PEPTIDYL PENTAFLUOROETHYLTITL 5 KETONES.REF J.MED.CHEM. V. 41 2461 1998REFN […]

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4I0P.G | HLA-DOA

General Structure Information 4i0p HLA-DOA hla-do in complex with hla-dm 3.2Å AUTH A.I.GUCE,S.E.MORTIMER,T.YOON,C.A.PAINTER,W.JIANG,AUTH 2 E.D.MELLINS,L.J.STERNTITL HLA-DO ACTS AS A SUBSTRATE MIMIC TO INHIBIT HLA-DM BY ATITL 2 COMPETITIVE MECHANISM.REF NAT.STRUCT.MOL.BIOL. V. 20 90 2013REFN ISSN 1545-9993PMID 23222639DOI 10.1038/NSMB.2460 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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