Assessment of Structural Intolerance and Durability
General Structure Information 2dmi TSHZ3 solution structure of the first and the second zf-c2h2 like domains of human teashirt homolog 3 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND THE SECONDTITL 2 ZF-C2H2 LIKE DOMAINS OF HUMAN TEASHIRT HOMOLOG 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4crs PKN2 human protein kinase n2 (pkn2, prkcl2) in complex with atpgammas 2.75Å AUTH S.MATHEA,S.KNAPPTITL STRUCTURE OF PKN2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xst LCN15 crystal structure of the human lipocalin 15 1.63Å AUTH J.R.C.MUNIZ,C.GILEADI,W.W.YUE,T.KROJER,E.UGOCHUKWU,AUTH 2 C.PHILLIPS,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN LIPOCALIN 15REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kdd CDCA8 solution structure of the conserved c-terminal dimerization domain of borealin -1.0Å AUTH E.BOURHIS,A.LINGEL,Q.PHUNG,W.J.FAIRBROTHER,AUTH 2 A.G.COCHRANTITL PHOSPHORYLATION OF A BOREALIN DIMERIZATION DOMAINTITL 2 IS REQUIRED FOR PROPER CHROMOSOME SEGREGATION.REF BIOCHEMISTRY V. 48 6783 2009REFN ISSN 0006-2960PMID 19530738DOI 10.1021/BI900530V Variant Set Distributions Mapped Variants
General Structure Information 2y96 DUPD1 structure of human dual-specificity phosphatase 27 2.38Å AUTH G.T.LOUNTOS,J.E.TROPEA,D.S.WAUGHTITL STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASETITL 2 AT 2.38A RESOLUTIONREF ACTA CRYSTALLOGR.,SECT.D V. 67 471 2011REFN ISSN 0907-4449PMID 21543850DOI 10.1107/S090744491100970X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lz1 NFE2L2 solution nmr structure of the dna-binding domain of human nf-e2- related factor 2, northeast structural genomics consortium (nesg) target hr3520o -1.0Å AUTH A.ELETSKY,S.V.S.R.K.PULAVARTI,D.LEE,E.KOHAN,H.JANJUA,R.XIAO,AUTH 2 T.B.ACTON,J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMANTITL 2 NF-E2-RELATED FACTOR 2, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3520OREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 3mpx FGD5 crystal structure of the dh and ph-1 domains of human fgd5 2.8Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE DH AND PH-1 DOMAINS OF HUMAN FGD5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3blj PARP15 crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1fpz CDKN3 crystal structure analysis of kinase associated phosphatase (kap) with a substitution of the catalytic site cysteine (cys140) to a serine 2.0Å AUTH H.SONG,N.HANLON,N.R.BROWN,M.E.NOBLE,L.N.JOHNSON,AUTH 2 D.BARFORDTITL PHOSPHOPROTEIN-PROTEIN INTERACTIONS REVEALED BYTITL 2 THE CRYSTAL STRUCTURE OF KINASE-ASSOCIATEDTITL 3 PHOSPHATASE IN COMPLEX WITH PHOSPHOCDK2.REF MOL.CELL V. 7 615 2001REFN ISSN 1097-2765PMID 11463386DOI 10.1016/S1097-2765(01)00208-8 […]