General Structure Information
| PDB ID | 4crs |
| HGNC Gene Label(s) | PKN2 |
| Structure Name | human protein kinase n2 (pkn2, prkcl2) in complex with atpgammas |
| Resolution | 2.75Å |
| Reference | AUTH S.MATHEA,S.KNAPPTITL STRUCTURE OF PKN2REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 329 |
| Number Of SNVs | 56 |
| Number Of Permutations | 25238 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.019 |
| p-value | 0.835 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:89273213 | rs373058309 | S>P | A:646 | (-28.19, 21.43, 182.20) |
| 1:89273214 | rs543625646 | S>Y | A:646 | (-28.19, 21.43, 182.20) |
| 1:89273241 | rs12085658 | Q>R | A:655 | (-6.21, 15.75, 185.13) |
| 1:89273245 | rs373212914 | D>E | A:656 | (-7.57, 13.04, 187.27) |
| 1:89273247 | rs376189560 | F>C | A:657 | (-9.58, 16.85, 189.13) |
| 1:89273249 | R>G | A:658 | (-16.69, 15.07, 189.15) | |
| 1:89273251 | R>S | A:658 | (-16.69, 15.07, 189.15) | |
| 1:89273258 | A>T | A:661 | (-19.16, 23.67, 190.38) | |
| 1:89273259 | rs559447625 | A>V | A:661 | (-19.16, 23.67, 190.38) |
| 1:89273370 | rs200476994 | L>F | A:672 | (-14.27, 25.11, 189.34) |
| 1:89273385 | rs537574477 COSM4010406 |
K>E | A:677 | (-9.74, 10.15, 190.78) |
| 1:89273394 | rs527828717 | N>H | A:680 | (-15.89, 11.46, 197.48) |
| 1:89273406 | A>T | A:684 | (-10.55, 24.34, 194.66) | |
| 1:89273409 | I>V | A:685 | (-9.85, 24.06, 190.52) | |
| 1:89273433 | I>V | A:693 | (-0.65, 35.11, 181.89) | |
| 1:89273451 | rs371052905 | V>I | A:699 | (4.80, 34.67, 184.35) |
| 1:89279358 | A>P | A:741 | (-17.23, 25.33, 202.25) | |
| 1:89279407 | P>R | A:757 | (-17.68, 38.97, 219.42) | |
| 1:89279415 | V>I | A:760 | (-12.45, 39.67, 217.31) | |
| 1:89287638 | C>S | A:765 | (-7.56, 34.55, 212.07) | |
| 1:89287644 | V>G | A:767 | (-3.33, 38.67, 212.85) | |
| 1:89287650 | G>A | A:769 | (-1.43, 35.09, 208.92) | |
| 1:89287671 | H>R | A:776 | (8.30, 33.43, 205.92) | |
| 1:89287673 | K>E | A:777 | (11.11, 38.66, 204.64) | |
| 1:89294169 | G>R | A:809 | (11.13, 43.29, 205.50) | |
| 1:89294173 | Y>C | A:810 | (11.55, 46.85, 210.06) | |
| 1:89294206 | rs549143118 | P>L | A:821 | (-10.00, 51.25, 196.06) |
| 1:89294242 | S>F | A:833 | (7.64, 54.04, 198.36) | |
| 1:89294254 | A>V | A:837 | (2.41, 48.67, 206.91) | |
| 1:89294271 | rs369061418 | L>F | A:843 | (-6.44, 44.83, 209.78) |
| 1:89294292 | M>V | A:850 | (-16.18, 43.03, 209.97) | |
| 1:89298480 | rs529717698 | D>E | A:872 | (-11.24, 62.86, 205.02) |
| 1:89298508 | T>A | A:882 | (-13.10, 51.94, 223.46) | |
| 1:89298523 | rs370637742 | I>V | A:887 | (-7.33, 48.63, 216.93) |
| 1:89298526 | rs548272772 | M>V | A:888 | (-10.08, 51.10, 214.12) |
| 1:89298769 | R>G | A:894 | (-3.24, 59.82, 207.42) | |
| 1:89298784 | rs374663309 | R>C | A:899 | (0.51, 52.44, 210.36) |
| 1:89298799 | rs571156003 | E>K | A:904 | (11.54, 44.90, 214.15) |
| 1:89298814 | rs201403675 | D>N | A:909 | (2.86, 45.49, 218.83) |
| 1:89298821 | K>R | A:911 | (-0.96, 39.37, 218.90) | |
| 1:89298824 | K>R | A:912 | (0.05, 44.02, 222.87) | |
| 1:89298830 | P>L | A:914 | (-7.01, 45.92, 224.20) | |
| 1:89298838 | R>W | A:917 | (-10.08, 41.82, 225.66) | |
| 1:89298839 | rs188265897 | R>Q | A:917 | (-10.08, 41.82, 225.66) |
| 1:89298943 | COSM912907 | A>T | A:923 | (-5.41, 27.99, 220.97) |
| 1:89298944 | rs557444302 | A>V | A:923 | (-5.41, 27.99, 220.97) |
| 1:89298976 | rs575369896 | I>V | A:934 | (-20.97, 26.74, 212.37) |
| 1:89298978 | I>M | A:934 | (-20.97, 26.74, 212.37) | |
| 1:89298979 | P>S | A:935 | (-20.84, 26.97, 208.47) | |
| 1:89298985 | rs543193317 | I>V | A:937 | (-22.42, 22.66, 205.00) |
| 1:89298991 | G>R | A:939 | (-23.04, 18.23, 201.75) | |
| 1:89298992 | G>E | A:939 | (-23.04, 18.23, 201.75) | |
| 1:89298995 | R>Q | A:940 | (-19.41, 15.28, 199.99) | |
| 1:89299019 | rs200518024 | D>G | A:948 | (-26.79, 32.14, 193.09) |
| 1:89299028 | rs368185560 | T>I | A:951 | (-23.65, 28.34, 191.40) |
| 1:89299040 | P>L | A:955 | (-18.96, 23.42, 185.39) | |
| 1:89299052 | P>L | A:959 | (-12.62, 27.52, 175.10) | |
| 1:89299055 | P>R | A:960 | (-9.14, 29.49, 174.24) | |
| 1:89299058 | R>Q | A:961 | (-11.85, 32.00, 169.75) | |
| 1:89299103 | D>A | A:976 | (9.54, 23.81, 186.22) | |
| 1:89299114 | I>V | A:980 | (2.66, 17.00, 193.74) | |
| 1:89299117 | A>T | A:981 | (2.27, 17.71, 197.85) | |
| 1:89299123 | rs184754507 | W>R | A:983 | (0.12, 17.22, 201.75) |