Assessment of Structural Intolerance and Durability
General Structure Information 4lec METTL21A human methyltransferase-like protein 21a 2.28Å AUTH H.ZENG,A.DONG,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKETITL 2 PROTEIN 21A IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1l0a TANK downstream regulator tank binds to the cd40 recognition site on traf3 2.9Å AUTH C.LI,C.Z.NI,M.L.HAVERT,E.CABEZAS,J.HE,D.KAISER,AUTH 2 J.C.REED,A.C.SATTERTHWAIT,G.CHENG,K.R.ELYTITL DOWNSTREAM REGULATOR TANK BINDS TO THE CD40TITL 2 RECOGNITION SITE ON TRAF3.REF STRUCTURE V. 10 403 2002REFN ISSN 0969-2126PMID 12005438DOI 10.1016/S0969-2126(02)00733-5 Variant Set Distributions Mapped Variants
General Structure Information 1xks NUP133 the crystal structure of the n-terminal domain of nup133 reveals a beta-propeller fold common to several nucleoporins 2.35Å AUTH I.C.BERKE,T.BOEHMER,G.BLOBEL,T.U.SCHWARTZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF NUP133 DOMAINS REVEALSTITL 2 MODULAR BUILDING BLOCKS OF THE NUCLEAR PORE COMPLEX.REF J.CELL BIOL. V. 167 591 2004REFN ISSN 0021-9525PMID 15557116DOI 10.1083/JCB.200408109 Variant Set Distributions […]
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p0k SCMH1 crystal structure of scmh1 1.75Å AUTH N.HERZANYCH,G.SENISTERRA,Y.LIU,L.CROMBET,P.LOPPNAU,AUTH 2 I.KOZIERADZKI,M.VEDADI,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,J.MINTITL STRUCTURE OF SCMH1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1h6e AP2M1 mu2 adaptin subunit (ap50) of ap2 adaptor (second domain), complexed with ctla-4 internalization peptide ttgvyvkmppt 3.6Å AUTH E.R.FOLLOWS,J.C.MCPHEAT,C.MINSHULL,N.C.MOORE,AUTH 2 R.A.PAUPTIT,S.ROWSELL,C.L.STACEY,J.J.STANWAY,AUTH 3 I.W.TAYLOR,W.M.ABBOTTTITL STUDY OF THE INTERACTION OF THE MEDIUM CHAIN MU2TITL 2 SUBUNIT OF THE CLATHRIN-ASSOCIATED ADAPTER PROTEINTITL 3 COMPLEX 2 WITH CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4TITL 4 AND CD28REF BIOCHEM.J. […]
General Structure Information 2l0a STAM solution nmr structure of signal transducing adapter molecule 1 stam-1 from homo sapiens, northeast structural genomics consortium target hr4479e -1.0Å AUTH Y.TANG,H.JANJUA,C.CICCOSANTI,R.SHASTRY,B.ROST,T.B.ACTON,AUTH 2 R.XIAO,J.K.EVERETT,G.T.MONTELIONE,C.H.ARROWSMITHTITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4479EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4m6t LEO1 structure of human paf1 and leo1 complex 2.5Å AUTH X.CHU,X.QIN,H.XU,L.LI,Z.WANG,F.LI,X.XIE,H.ZHOU,Y.SHEN,J.LONGTITL STRUCTURAL INSIGHTS INTO PAF1 COMPLEX ASSEMBLY AND HISTONETITL 2 BINDINGREF NUCLEIC ACIDS RES. V. 41 10619 2013REFN ISSN 0305-1048PMID 24038468DOI 10.1093/NAR/GKT819 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 2yho MYLIP the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Mapped Variants