Assessment of Structural Intolerance and Durability
General Structure Information 2jvz KHSRP solution nmr structure of the second and third kh domains of ksrp -1.0Å AUTH I.DIAZ-MORENO,D.HOLLINGWORTH,M.F.GARCIA-MAYORAL,AUTH 2 G.KELLY,S.MARTIN,C.Y.CHEN,A.RAMOSTITL SOLUTION NMR STRUCTURE OF THE SECOND AND THIRD KHTITL 2 DOMAINS OF KSRPREF TO BE PUBLISHED 2007REFN Variant Set Distributions Mapped Variants
General Structure Information 2ksn UBTD2 solution structure of the n-terminal domain of dc-ubp/ubtd2 -1.0Å AUTH A.SONG,C.ZHOU,X.GUAN,K.SZE,H.HUTITL SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DC-UBP/UBTD2TITL 2 AND ITS INTERACTION WITH UBIQUITINREF PROTEIN SCI. V. 19 1104 2010REFN ISSN 0961-8368PMID 20440844DOI 10.1002/PRO.386 Variant Set Distributions Mapped Variants
General Structure Information 2ylm USP7 mechanism of usp7 (hausp) activation by its c-terminal ubiquitin-like domain (hubl) and allosteric regulation by gmp-synthetase. 2.7Å AUTH A.C.FAESEN,A.M.G.DIRAC,A.SHANMUGHAM,H.OVAA,A.PERRAKIS,AUTH 2 T.K.SIXMATITL MECHANISM OF USP7/HAUSP ACTIVATION BY ITS C- TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN AND ALLOSTERIC REGULATION BYTITL 3 GMP-SYNTHETASEREF MOL.CELL V. 44 147 2011REFN ISSN 1097-2765PMID 21981925DOI 10.1016/J.MOLCEL.2011.06.034 Variant Set Distributions […]
General Structure Information 1ury CYGB cytoglobin cavities 2.4Å AUTH D.DE SANCTIS,S.DEWILDE,A.PESCE,L.MOENS,P.ASCENZI,AUTH 2 T.HANKELN,T.BURMESTER,M.BOLOGNESITITL CYTOGLOBIN CAVITIESREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 316 1217 2004REFN ISSN 0006-291XPMID 15044115DOI 10.1016/J.BBRC.2004.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r0b STYX crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein 1.6Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,T.P.DILORENZO,AUTH 2 V.MALASHKEVICH,S.R.WASSERMAN,S.SWAMINATHAN,S.ESWARAMOORTHY,AUTH 3 R.AGARWAL,D.KUMARAN,M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,AUTH 4 J.ALVARADO,U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 5 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Mapped Variants
General Structure Information 4hnm CTNNBL1 crystal structure of human catenin-beta-like 1 56 kda fragment 2.9Å AUTH X.HUANG,G.WANG,Y.WU,Z.DUTITL THE STRUCTURE OF FULL-LENGTH HUMAN CTNNBL1 REVEALS ATITL 2 DISTINCT MEMBER OF THE ARMADILLO-REPEAT PROTEIN FAMILY.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1598 2013REFN ISSN 0907-4449PMID 23897482DOI 10.1107/S0907444913011360 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3nw0 NSMCE1 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hsa IL17RA structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 2nq3 ITCH crystal structure of the c2 domain of human itchy homolog e3 ubiquitin protein ligase 1.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL THE C2 DOMAIN OF HUMAN ITCHY HOMOLOG E3 UBIQUITINTITL 2 PROTEIN LIGASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ei4 DDB2 structure of the hsddb1-hsddb2 complex 3.3Å AUTH A.SCRIMA,R.KONICKOVA,B.K.CZYZEWSKI,Y.KAWASAKI,P.D.JEFFREY,AUTH 2 R.GROISMAN,Y.NAKATANI,S.IWAI,N.P.PAVLETICH,N.H.THOMATITL STRUCTURAL BASIS OF UV DNA-DAMAGE RECOGNITION BY THETITL 2 DDB1-DDB2 COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 135 1213 2008REFN ISSN 0092-8674PMID 19109893DOI 10.1016/J.CELL.2008.10.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants