Assessment of Structural Intolerance and Durability
General Structure Information 2r2j ERP44 crystal structure of human erp44 2.6Å AUTH L.K.WANG,L.WANG,S.VAVASSORI,S.J.LI,H.KE,T.ANELLI,M.DEGANO,AUTH 2 R.RONZONI,R.SITIA,F.SUN,C.C.WANGTITL CRYSTAL STRUCTURE OF HUMAN ERP44 SHOWS A DYNAMIC FUNCTIONALTITL 2 MODULATION BY ITS CARBOXY-TERMINAL TAIL.REF EMBO REP. 2008REFN ESSN 1469-3178PMID 18552768DOI 10.1038/EMBOR.2008.88 Variant Set Distributions Mapped Variants
General Structure Information 4lt6 PAPOLG crystal structure of human poly(a) polymerase gamma 2.79Å AUTH Q.YANG,L.W.NAUSCH,G.MARTIN,W.KELLER,S.DOUBLIETITL CRYSTAL STRUCTURE OF HUMAN POLY(A) POLYMERASE GAMMA REVEALSTITL 2 A CONSERVED CATALYTIC CORE FOR CANONICAL POLY(A)TITL 3 POLYMERASES.REF J.MOL.BIOL. V. 426 43 2014REFN ISSN 0022-2836PMID 24076191DOI 10.1016/J.JMB.2013.09.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2nsq NEDD4L crystal structure of the c2 domain of the human e3 ubiquitin-protein ligase nedd4-like protein 1.85Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE C2 DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASETITL 2 NEDD4-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2e9x GINS3 the crystal structure of human gins core complex 2.3Å AUTH K.KAMADA,Y.KUBOTA,T.ARATA,Y.SHINDO,F.HANAOKATITL STRUCTURE OF THE HUMAN GINS COMPLEX AND ITSTITL 2 ASSEMBLY AND FUNCTIONAL INTERFACE IN REPLICATIONTITL 3 INITIATIONREF NAT.STRUCT.MOL.BIOL. V. 14 388 2007REFN ISSN 1545-9993PMID 17417653DOI 10.1038/NSMB1231 Variant Set Distributions Mapped Variants
General Structure Information 2e9x GINS4 the crystal structure of human gins core complex 2.3Å AUTH K.KAMADA,Y.KUBOTA,T.ARATA,Y.SHINDO,F.HANAOKATITL STRUCTURE OF THE HUMAN GINS COMPLEX AND ITSTITL 2 ASSEMBLY AND FUNCTIONAL INTERFACE IN REPLICATIONTITL 3 INITIATIONREF NAT.STRUCT.MOL.BIOL. V. 14 388 2007REFN ISSN 1545-9993PMID 17417653DOI 10.1038/NSMB1231 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2yu8 ZNF347 solution structure of the c2h2 type zinc finger (region 648- 680) of human zinc finger protein 347 -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 648-680) OF HUMAN ZINC FINGER PROTEIN 347REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wou TXNDC17 crystal structure of human trp14 1.8Å AUTH J.R.WOO,S.J.KIM,W.JEONG,Y.H.CHO,S.C.LEE,Y.J.CHUNG,AUTH 2 S.G.RHEE,S.E.RYUTITL STRUCTURAL BASIS OF CELLULAR REDOX REGULATION BYTITL 2 HUMAN TRP14REF J.BIOL.CHEM. V. 279 48120 2004REFN ISSN 0021-9258PMID 15355959DOI 10.1074/JBC.M407079200 Variant Set Distributions Mapped Variants
General Structure Information 3edt KLC2 crystal structure of the mutated s328n hklc2 tpr domain 2.7Å AUTH H.ZHU,Y.SHEN,F.MACKENZIE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF MUTATED S328N TPR DOMAIN OF HUMANTITL 2 KINESIN LIGHT CHAIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4nac RPRD1A crystal structure of the n-terminal domain of p15rs 2.0Å AUTH K.MEI,Z.JIN,F.REN,Y.WANG,Z.CHANG,X.WANGTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF P15RSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ctd ZNF512 solution structure of two zf-c2h2 domains from human zinc finger protein 512 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF TWO ZF-C2H2 DOMAINS FROMTITL 2 HUMAN ZINC FINGER PROTEIN 512REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants