Assessment of Structural Intolerance and Durability
General Structure Information 1wgo SORCS2 solution structure of the pkd domain from human vps10 domain-containing receptor sorcs2 -1.0Å AUTH E.CHIKAYAMA,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PKD DOMAIN FROM HUMANTITL 2 VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3rmu MCEE crystal structure of human methylmalonyl-coa epimerase, mcee 1.8Å AUTH A.CHAIKUAD,E.KRYSZTOFINSKA,D.S.FROESE,W.W.YUE,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA EPIMERASE, MCEEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y9q MKNK1 crystal structure of human erk2 complexed with a mapk docking peptide 1.55Å AUTH A.GARAI,A.ZEKE,G.GOGL,I.TORO,F.FORDOS,H.BLANKENBURG,AUTH 2 T.BARKAI,J.VARGA,A.ALEXA,D.EMIG,M.ALBRECHT,A.REMENYITITL SPECIFICITY OF LINEAR MOTIFS THAT BIND TO A COMMON MITOGEN-TITL 2 ACTIVATED PROTEIN KINASE DOCKING GROOVE.REF SCI. SIGNAL V. 5 74 2012REFN ESSN 1937-9145PMID 23047924DOI 10.1126/SCISIGNAL.2003004 Variant Set Distributions Mapped Variants
General Structure Information 4dwn C9orf89 crystal structure of human bincard card 1.58Å AUTH K.E.CHEN,A.A.RICHARDS,T.T.CARADOC-DAVIES,P.R.VAJJHALA,AUTH 2 G.ROBIN,L.H.LUA,J.M.HILL,K.SCHRODER,M.J.SWEET,S.KELLIE,AUTH 3 B.KOBE,J.MARTINTITL THE STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN OF BINCARDTITL 2 REVEALS THAT ALL THREE CYSTEINES CAN BE OXIDIZED.REF ACTA CRYSTALLOGR.,SECT.D V. 69 774 2013REFN ISSN 0907-4449PMID 23633586DOI 10.1107/S0907444913001558 Variant Set Distributions Mapped Variants
General Structure Information 3no8 BTBD2 crystal structure of the phr domain from human btbd2 protein 2.2Å AUTH P.SAMPATHKUMARTITL CRYSTAL STRUCTURE OF THE PHR DOMAIN FROM HUMAN BTBD2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d4c SH3GL2 crystal structure of the endophilin bar domain mutant 2.4Å AUTH M.MASUDA,S.TAKEDA,M.SONE,T.OHKI,H.MORI,Y.KAMIOKA,AUTH 2 N.MOCHIZUKITITL ENDOPHILIN BAR DOMAIN DRIVES MEMBRANE CURVATURE BYTITL 2 TWO NEWLY IDENTIFIED STRUCTURE-BASED MECHANISMSREF EMBO J. V. 25 2889 2006REFN ISSN 0261-4189PMID 16763557DOI 10.1038/SJ.EMBOJ.7601176 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2emp ZNF347 solution structure of the c2h2 type zinc finger (region 536- 568) of human zinc finger protein 347 -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 536-568) OF HUMAN ZINC FINGER PROTEIN 347REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q9v MAGI1 crystal structure of the c890s mutant of the 4th pdz domain of human membrane associated guanylate kinase 2.0Å AUTH E.S.PILKA,V.HOZJAN,K.L.KAVANAGH,E.PAPAGRIGORIOU,C.COOPER,AUTH 2 J.M.ELKINS,D.A.DOYLE,F.VON DELFT,M.SUNDSTROM,C.A.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE C890S MUTANT OF THE 4TH PDZ DOMAINTITL 2 OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2p31 GPX7 crystal structure of human glutathione peroxidase 7 2.0Å AUTH K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lgy RBCK1 ubiquitin-like domain from hoil-1 -1.0Å AUTH S.A.BEASLEY,S.S.SAFADI,K.R.BARBER,G.S.SHAWTITL SOLUTION STRUCTURE OF THE E3 LIGASE HOIL-1 UBL DOMAIN.REF PROTEIN SCI. V. 21 1085 2012REFN ISSN 0961-8368PMID 22517668DOI 10.1002/PRO.2080 Variant Set Distributions Mapped Variants