2R2J.A | ERP44

General Structure Information

PDB ID	2r2j
HGNC Gene Label(s)	ERP44
Structure Name	crystal structure of human erp44
Resolution	2.6Å
Reference	AUTH L.K.WANG,L.WANG,S.VAVASSORI,S.J.LI,H.KE,T.ANELLI,M.DEGANO,AUTH 2 R.RONZONI,R.SITIA,F.SUN,C.C.WANGTITL CRYSTAL STRUCTURE OF HUMAN ERP44 SHOWS A DYNAMIC FUNCTIONALTITL 2 MODULATION BY ITS CARBOXY-TERMINAL TAIL.REF EMBO REP. 2008REFN ESSN 1469-3178PMID 18552768DOI 10.1038/EMBOR.2008.88

Variant Set Distributions

ExAC Variants

Number Of Residues	320
Number Of SNVs	49
Number Of Permutations	8353
Optimal Distance Threshold	19.0
K Statistic	0.196
p-value	0.111

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:102822394		D>N	A:11	(42.62, 32.89, 57.89)
9:102822389	rs200649927	E>D	A:12	(42.38, 36.34, 62.69)
9:102822382	rs368653588	N>H	A:15	(39.30, 37.59, 57.47)
9:102820138	rs143034960	N>S	A:16	(39.60, 40.95, 60.66)
9:102820122		L>F	A:21	(50.15, 45.03, 51.32)
9:102814809		R>P	A:30	(68.91, 38.04, 42.08)
9:102814786		I>V	A:38	(61.41, 49.01, 50.11)
9:102814775		E>D	A:41	(60.96, 52.56, 55.01)
9:102814776	rs371852623	E>G	A:41	(60.96, 52.56, 55.01)
9:102814768		D>N	A:44	(57.78, 51.85, 59.58)
9:102814737		N>S	A:54	(43.10, 46.02, 62.17)
9:102814714		D>N	A:62	(58.25, 31.87, 52.65)
9:102814699		S>P	A:67	(53.16, 25.89, 49.41)
9:102784501	rs573981419	I>M	A:69	(49.47, 30.07, 51.47)
9:102784463	rs372324885	K>R	A:82	(48.04, 40.29, 46.20)
9:102784385		R>K	A:108	(49.44, 57.54, 51.41)
9:102784371		D>N	A:113	(38.29, 59.42, 49.23)
9:102783006	rs375903014	K>R	A:131	(33.23, 58.67, 33.56)
9:102783003		R>I	A:132	(31.30, 54.21, 33.30)
9:102782997		I>T	A:134	(27.54, 54.51, 40.47)
9:102782970		S>L	A:143	(23.95, 51.62, 57.32)
9:102782937	rs150455027	N>S	A:154	(36.83, 50.69, 48.36)
9:102782905		A>S	A:165	(23.23, 60.84, 49.08)
9:102780594		D>H	A:168	(15.53, 63.72, 52.77)
9:102780564	rs536978172	D>N	A:178	(18.07, 53.15, 50.74)
9:102780548	rs144693772	K>R	A:183	(23.68, 58.20, 35.73)
9:102780546		P>S	A:184	(25.12, 55.86, 31.90)
9:102780542		P>R	A:185	(27.55, 56.87, 29.15)
9:102778710		P>L	A:190	(18.85, 55.33, 30.13)
9:102778701		V>G	A:193	(17.49, 50.73, 38.73)
9:102778702		V>M	A:193	(17.49, 50.73, 38.73)
9:102778683		T>I	A:199	(22.41, 43.74, 52.63)
9:102778676	rs151032851	F>L	A:201	(29.56, 42.32, 48.60)
9:102778668		T>S	A:204	(25.72, 44.84, 45.13)
9:102778657		I>F	A:208	(28.11, 47.80, 40.48)
9:102769910		S>N	A:246	(34.14, 49.58, 14.43)
9:102769883		A>V	A:255	(27.74, 39.27, 22.18)
9:102769871		I>K	A:259	(28.81, 34.61, 24.92)
9:102768917		F>C	A:267	(36.11, 39.14, 24.52)
9:102768904		D>E	A:271	(44.52, 53.33, 19.81)
9:102768906		D>N	A:271	(44.52, 53.33, 19.81)
9:102768873		I>V	A:282	(50.01, 41.83, 11.94)
9:102768870	rs142824253	Q>E	A:283	(52.85, 42.49, 8.77)
9:102768861	rs148690517	P>S	A:286	(47.19, 52.62, 11.41)
9:102768807		G>R	A:304	(40.57, 39.97, 8.04)
9:102747349		I>T	A:311	(30.16, 36.55, 7.78)
9:102747334	rs373546780	K>R	A:316	(32.06, 30.94, 16.98)
9:102747325		V>A	A:319	(37.89, 31.77, 18.53)
9:102747326		V>I	A:319	(37.89, 31.77, 18.53)
9:102747323	rs558263354	F>L	A:320	(36.12, 26.66, 17.47)
9:102747313		H>R	A:323	(41.03, 27.46, 21.29)
9:102747314		H>Y	A:323	(41.03, 27.46, 21.29)
9:102747308		G>R	A:325	(45.37, 24.71, 15.85)
9:102744973		S>N	A:352	(55.93, 30.32, 11.65)