Assessment of Structural Intolerance and Durability
General Structure Information 1lb6 TRAF6 traf6-cd40 complex 1.8Å AUTH H.YE,J.R.ARRON,B.LAMOTHE,M.CIRILLI,T.KOBAYASHI,AUTH 2 N.K.SHEVDE,D.SEGAL,O.K.DZIVENU,M.VOLOGODSKAIA,AUTH 3 M.YIM,K.DU,S.SINGH,J.W.PIKE,B.G.DARNAY,Y.CHOI,H.WUTITL DISTINCT MOLECULAR MECHANISM FOR INITIATING TRAF6TITL 2 SIGNALLING.REF NATURE V. 418 443 2002REFN ISSN 0028-0836PMID 12140561DOI 10.1038/NATURE00888 Variant Set Distributions Mapped Variants
General Structure Information 2cxk CAMTA1 crystal structure of the tig domain of human calmodulin- binding transcription activator 1 (camta1) 1.85Å AUTH A.A.PIOSZAK,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE TIG DOMAIN OF HUMANTITL 2 CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 1TITL 3 (CAMTA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2oud DUSP10 crystal structure of the catalytic domain of human mkp5 2.8Å AUTH X.TAO,L.TONGTITL CRYSTAL STRUCTURE OF THE MAP KINASE BINDING DOMAINTITL 2 AND THE CATALYTIC DOMAIN OF HUMAN MKP5.REF PROTEIN SCI. V. 16 880 2007REFN ISSN 0961-8368PMID 17400920DOI 10.1110/PS.062712807 Variant Set Distributions Mapped Variants
General Structure Information 4bfb BACE2 bace2 xaperone complex 2.21Å AUTH D.W.BANNER,B.GSELL,J.BENZ,J.BERTSCHINGER,D.BURGER,S.BRACK,AUTH 2 S.CUPPULERI,M.DEBULPAEP,A.GAST,D.GRABULOVSKI,M.HENNIG,AUTH 3 H.HILPERT,W.HUBER,A.KUGLSTATTER,E.KUSZNIR,T.LAEREMANS,AUTH 4 H.MATILE,C.MISCENIC,A.RUFER,D.SCHLATTER,J.STEYEART,M.STIHLE,AUTH 5 R.THOMA,M.WEBER,A.RUFTITL MAPPING THE CONFORMATIONAL SPACE ACCESSIBLE TO BACE2 USINGTITL 2 SURFACE MUTANTS AND CO-CRYSTALS WITH FAB-FRAGMENTS,TITL 3 FYNOMERS, AND XAPERONESREF ACTA CRYSTALLOGR.,SECT.D V. 69 1124 2013REFN ISSN 0907-4449PMID 23695257DOI 10.1107/S0907444913006574 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1go4 MAD1L1 crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. 2.05Å AUTH L.SIRONI,M.MAPELLI,S.KNAPP,A.ANTONI,K.T.JEANG,AUTH 2 A.MUSACCHIOTITL CRYSTAL STRUCTURE OF THE TETRAMERIC MAD1-MAD2 CORETITL 2 COMPLEX: IMPLICATIONS OF A SAFETY BELT BINDINGTITL 3 MECHANISM FOR THE SPINDLE CHECKPOINTREF EMBO J. V. 21 2496 2002REFN ISSN 0261-4189PMID 12006501DOI 10.1093/EMBOJ/21.10.2496 […]
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ikd SNX11 crystal structure of snx11 px domain 1.6Å AUTH J.XU,T.XU,J.LIUTITL STRUCTURE OF SORTING NEXIN 11 (SNX11) REVEALS A NOVELTITL 2 EXTENDED PX DOMAIN (PXE DOMAIN) CRITICAL FOR THE INHIBITIONTITL 3 OF SORTING NEXIN 10 (SNX10) INDUCED VACUOLATIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2df3 SIGLEC7 the structure of siglec-7 in complex with alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl 1.9Å AUTH H.ATTRILL,H.TAKAZAWA,S.WITT,S.KELM,R.ISECKE,R.BROSSMER,AUTH 2 T.ANDO,H.ISHIDA,M.KISO,P.R.CROCKER,D.M.F.VAN AALTENTITL THE STRUCTURE OF SIGLEC-7 IN COMPLEX WITH SIALOSIDES: LEADSTITL 2 FOR RATIONAL STRUCTURE-BASED INHIBITOR DESIGNREF BIOCHEM.J. V. 397 271 2006REFN ISSN 0264-6021PMID 16623661DOI 10.1042/BJ20060103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2eoo ZKSCAN5 solution structure of the c2h2 type zinc finger (region 425- 457) of human zinc finger protein 95 homolog -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 425-457) OF HUMAN ZINC FINGER PROTEIN 95TITL 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1kbh NCOA3 mutual synergistic folding in the interaction between nuclear receptor coactivators cbp and actr -1.0Å AUTH S.J.DEMAREST,M.MARTINEZ-YAMOUT,J.CHUNG,H.CHEN,W.XU,AUTH 2 H.J.DYSON,R.M.EVANS,P.E.WRIGHTTITL MUTUAL SYNERGISTIC FOLDING IN RECRUITMENT OFTITL 2 CBP/P300 BY P160 NUCLEAR RECEPTOR COACTIVATORS.REF NATURE V. 415 549 2002REFN ISSN 0028-0836PMID 11823864DOI 10.1038/415549A Variant Set Distributions Mapped Variants