Assessment of Structural Intolerance and Durability
General Structure Information 2wtk CAB39 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f37 TRPV2 crystal structure of the ankyrin repeat domain of human trpv2 1.7Å AUTH C.J.MCCLEVERTY,E.KOESEMA,A.PATAPOUTIAN,S.A.LESLEY,AUTH 2 A.KREUSCHTITL CRYSTAL STRUCTURE OF THE HUMAN TRPV2 CHANNELTITL 2 ANKYRIN REPEAT DOMAIN.REF PROTEIN SCI. V. 15 2201 2006REFN ISSN 0961-8368PMID 16882997DOI 10.1110/PS.062357206 Variant Set Distributions Mapped Variants
General Structure Information 1rl1 SUGT1 solution structure of human sgt1 cs domain -1.0Å AUTH Y.-T.LEE,J.JACOB,W.MICHOWSKI,M.NOWOTNY,J.KUZNICKI,AUTH 2 W.J.CHAZINTITL HUMAN SGT1 BINDS HSP90 THROUGH THE CHORD-SGT1TITL 2 DOMAIN AND NOT THE TETRATRICOPEPTIDE REPEAT DOMAINREF J.BIOL.CHEM. V. 279 16511 2004REFN ISSN 0021-9258PMID 14761955DOI 10.1074/JBC.M400215200 Variant Set Distributions Mapped Variants
General Structure Information 2ch0 LEMD3 solution structure of the human man1 c-terminal domain (residues 655-775) -1.0Å AUTH S.CAPUTO,J.COUPRIE,I.DUBAND-GOULET,F.LIN,S.BRAUD,AUTH 2 M.GONDRY,H.J.WORMAN,B.GILQUIN,S.ZINN-JUSTINTITL THE CARBOXYL-TERMINAL NUCLEOPLASMIC REGION OF MAN1TITL 2 EXHIBITS A DNA BINDING WINGED HELIX DOMAIN.REF J.BIOL.CHEM. V. 281 18208 2006REFN ISSN 0021-9258PMID 16648637DOI 10.1074/JBC.M601980200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2xsz RUVBL1 the dodecameric human ruvbl1:ruvbl2 complex with truncated domains ii 3.0Å AUTH S.GORYNIA,T.M.BANDEIRAS,F.G.PINHO,C.E.MCVEY,C.VONRHEIN,AUTH 2 A.ROUND,D.I.SVERGUN,P.DONNER,P.M.MATIAS,M.A.CARRONDOTITL STRUCTURAL AND FUNCTIONAL INSIGHTS INTO A DODECAMERICTITL 2 MOLECULAR MACHINE – THE RUVBL1/RUVBL2 COMPLEX.REF J.STRUCT.BIOL. V. 176 279 2011REFN ISSN 1047-8477PMID 21933716DOI 10.1016/J.JSB.2011.09.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2vwf GAB2 grb2 sh3c (2) 1.58Å AUTH M.HARKIOLAKI,T.TSIRKA,M.LEWITZKY,P.C.SIMISTER,AUTH 2 D.JOSHI,L.E.BIRD,E.Y.JONES,N.OREILLY,S.M.FELLERTITL DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2TITL 2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2.REF STRUCTURE V. 17 809 2009REFN ISSN 0969-2126PMID 19523899DOI 10.1016/J.STR.2009.03.017 Variant Set Distributions Mapped Variants
General Structure Information 2dj0 TMX2 the solution structure of the thioredoxin domain of human thioredoxin-related transmembrane protein 2 -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIOREDOXIN DOMAINTITL 2 OF HUMAN THIOREDOXIN-RELATED TRANSMEMBRANE PROTEINTITL 3 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pso STARD13 human stard13 (dlc2) lipid transfer and protein localization domain 2.8Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 3a7h STK24 human mst3 kinase in complex with atp 1.96Å AUTH T.P.KO,W.Y.JENG,C.I.LIU,M.D.LAI,C.L.WU,W.J.CHANG,H.L.SHR,AUTH 2 T.J.LU,A.H.J.WANGTITL STRUCTURES OF HUMAN MST3 KINASE IN COMPLEX WITH ADENINE, ADPTITL 2 AND MN2+.REF ACTA CRYSTALLOGR.,SECT.D V. 66 145 2010REFN ISSN 0907-4449PMID 20124694DOI 10.1107/S0907444909047507 Variant Set Distributions Mapped Variants
General Structure Information 2jis CSAD human cysteine sulfinic acid decarboxylase (csad) in complex with plp. 1.6Å AUTH R.COLLINS,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTENYOVA,L.LEHTIO,AUTH 5 P.NORDLUND,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 P.STENMARK,M.SUNDSTROM,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 8 L.HOLMBERG-SCHIAVONETITL THE CRYSTAL STRUCTURE OF HUMAN CYSTEINE SULFINICTITL 2 ACID DECARBOXYLASE (CSAD)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]